Model free sliding mode controller for blood glucose control: Towards artificial pancreas without need to mathematical model of the system

2020 ◽  
Vol 195 ◽  
pp. 105663
Author(s):  
Nahid Ebrahimi ◽  
Sadjaad Ozgoli ◽  
Amin Ramezani
Keyword(s):  
Mathematical Model ◽  
Blood Glucose ◽  
Glucose Control ◽  
Sliding Mode ◽  
Artificial Pancreas ◽  
Blood Glucose Control ◽  
Sliding Mode Controller ◽  
Model Free

scholarly journals Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Nils K. Skjaervold ◽  
Dan Östling ◽  
Dag R. Hjelme ◽  
Olav Spigset ◽  
Oddveig Lyng ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Artificial Pancreas ◽  
Blood Glucose Control ◽  
Calibration Procedure ◽  
Target Range ◽  
Glucose Levels ◽  
Intravenous Insulin ◽  
Oscillatory Pattern ◽  
Blood Glucose Monitor

The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5–6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.

Evolution Of β-Tg Level In Diabetic Patients Undergoing Artificial Pancreas Treatment

1981 ◽  
Author(s):  
Ph Voisin ◽  
D Rouselle ◽  
C Guimont ◽  
P Drouin ◽  
J F Stoltz
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Healthy Subjects ◽  
Artificial Pancreas ◽  
Blood Glucose Control ◽  
Specific Protein ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Plasma β-thromboglobulin was measured at 0, 24 and 48 hours on 27 healthy subjects and 22 insulin-dependent diabetic patients undergoing a 48-hour artificial pancreas treatment (Biostator).Before treatment all the diabetic patients revealed β-TG levels which were significantly higher than those measured in healthy subjectsOn average, after 24 hours of blood glucose control, β-TG levels in the diabetic patients were not significantly reduced in comparison with the original β-TG levels. In contrast, after 48 hours of blood glucose control, plasma β-TG levels were significantly reduced.As β-TG is a platelet-specific protein, which is considered to be an indicator of the cell’s release reaction, these results suggest that short-term control of blood glucose levels is likely to influence platelet activation in diabetic patients.

An artificial pancreas for automated blood glucose control in patients with Type 1 diabetes

2015 ◽  
Vol 6 (5) ◽  
pp. 609-619 ◽  
Author(s):  
Signe Schmidt ◽  
Dimitri Boiroux ◽  
Ajenthen Ranjan ◽  
John Bagterp Jørgensen ◽  
Henrik Madsen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Glucose Control ◽  
Artificial Pancreas ◽  
Blood Glucose Control
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