Mathematical modeling of radiotherapy cancer treatment using Caputo fractional derivative

2020 ◽  
Vol 188 ◽  
pp. 105306 ◽  
Author(s):  
Musiliu Folarin Farayola ◽  
Sharidan Shafie ◽  
Fuaada Mohd Siam ◽  
Ilyas Khan
Keyword(s):  
Mathematical Modeling ◽  
Fractional Derivative ◽  
Cancer Treatment ◽  
Caputo Fractional Derivative

scholarly journals Mathematical Modeling and Dynamics of Oncolytic Virotherapy

2021 ◽  
Author(s):  
Abdullah Abu-Rqayiq
Keyword(s):  
Mathematical Modeling ◽  
Fractional Derivative ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Viral Infections ◽  
Oncolytic Virotherapy ◽  
Control Parameters ◽  
Approaches To Studying ◽  
Asymptotic Dynamics ◽  
The Cost

Oncolytic virotherapy is a cancer treatment that uses competent replicating viruses to destroy cancer cells. This field progressed from earlier observations of accidental viral infections causing remission in many malignancies to virus drugs targeting and killing cancer cells. In this chapter, we study some basic models of the oncolytic virotherapy and their dynamics. We show how the dynamical system’s theory can capture the behavior of the solutions of those models and provide different approaches to studying the models. We study the thresholds that enable us to classify asymptotic dynamics of the solutions. Fractional-derivative approach tells us about the memory of the derivative and related solutions of the models. We also study the affect of introducing control parameters on the cost of the therapy.

scholarly journals A Convergent Collocation Approach for Generalized Fractional Integro-Differential Equations Using Jacobi Poly-Fractonomials

Mathematics ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 979
Author(s):  
Sandeep Kumar ◽  
Rajesh K. Pandey ◽  
H. M. Srivastava ◽  
G. N. Singh
Keyword(s):  
Differential Equation ◽  
Fractional Derivative ◽  
Collocation Method ◽  
Caputo Fractional Derivative ◽  
Fractional Derivatives ◽  
Special Cases ◽  
Collocation Approach ◽  
Linear And Nonlinear ◽  
Simulation Results ◽  
Theoretical Results

In this paper, we present a convergent collocation method with which to find the numerical solution of a generalized fractional integro-differential equation (GFIDE). The presented approach is based on the collocation method using Jacobi poly-fractonomials. The GFIDE is defined in terms of the B-operator introduced recently, and it reduces to Caputo fractional derivative and other fractional derivatives in special cases. The convergence and error analysis of the proposed method are also established. Linear and nonlinear cases of the considered GFIDEs are numerically solved and simulation results are presented to validate the theoretical results.

scholarly journals Caputo Fractional Derivative and Quantum-Like Coherence

Entropy ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 211
Author(s):  
Garland Culbreth ◽  
Mauro Bologna ◽  
Bruce J. West ◽  
Paolo Grigolini
Keyword(s):  
Diffusion Equation ◽  
Fractional Derivative ◽  
Anomalous Diffusion ◽  
Caputo Fractional Derivative ◽  
Quantum Coherence ◽  
Time Derivative ◽  
The Other ◽  
Diffusion Equations ◽  
Self Organization ◽  
Ordinary Time

We study two forms of anomalous diffusion, one equivalent to replacing the ordinary time derivative of the standard diffusion equation with the Caputo fractional derivative, and the other equivalent to replacing the time independent diffusion coefficient of the standard diffusion equation with a monotonic time dependence. We discuss the joint use of these prescriptions, with a phenomenological method and a theoretical projection method, leading to two apparently different diffusion equations. We prove that the two diffusion equations are equivalent and design a time series that corresponds to the anomalous diffusion equation proposed. We discuss these results in the framework of the growing interest in fractional derivatives and the emergence of cognition in nature. We conclude that the Caputo fractional derivative is a signature of the connection between cognition and self-organization, a form of cognition emergence different from the other source of anomalous diffusion, which is closely related to quantum coherence. We propose a criterion to detect the action of self-organization even in the presence of significant quantum coherence. We argue that statistical analysis of data using diffusion entropy should help the analysis of physiological processes hosting both forms of deviation from ordinary scaling.

scholarly journals Nonexistence Results for Higher Order Fractional Differential Inequalities with Nonlinearities Involving Caputo Fractional Derivative

Mathematics ◽  
2021 ◽  
Vol 9 (16) ◽  
pp. 1866
Author(s):  
Mohamed Jleli ◽  
Bessem Samet ◽  
Calogero Vetro
Keyword(s):  
Fractional Derivative ◽  
Caputo Fractional Derivative ◽  
A Priori Estimates ◽  
Sufficient Conditions ◽  
Global Solutions ◽  
Higher Order ◽  
Differential Inequalities ◽  
Structure Of Solutions ◽  
Nonlinear Capacity ◽  
Fractional Differential

Higher order fractional differential equations are important tools to deal with precise models of materials with hereditary and memory effects. Moreover, fractional differential inequalities are useful to establish the properties of solutions of different problems in biomathematics and flow phenomena. In the present work, we are concerned with the nonexistence of global solutions to a higher order fractional differential inequality with a nonlinearity involving Caputo fractional derivative. Namely, using nonlinear capacity estimates, we obtain sufficient conditions for which we have no global solutions. The a priori estimates of the structure of solutions are obtained by a precise analysis of the integral form of the inequality with appropriate choice of test function.

scholarly journals Non-Instantaneous Impulsive Boundary Value Problems Containing Caputo Fractional Derivative of a Function with Respect to Another Function and Riemann–Stieltjes Fractional Integral Boundary Conditions

Axioms ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 130
Author(s):  
Suphawat Asawasamrit ◽  
Yasintorn Thadang ◽  
Sotiris K. Ntouyas ◽  
Jessada Tariboon
Keyword(s):  
Boundary Conditions ◽  
Fractional Derivative ◽  
Boundary Value Problems ◽  
Caputo Fractional Derivative ◽  
Fractional Integral ◽  
Boundary Value ◽  
Integral Boundary Conditions ◽  
Integral Boundary ◽  
Uniqueness Results ◽  
Nonlinear Alternative

In the present article we study existence and uniqueness results for a new class of boundary value problems consisting by non-instantaneous impulses and Caputo fractional derivative of a function with respect to another function, supplemented with Riemann–Stieltjes fractional integral boundary conditions. The existence of a unique solution is obtained via Banach’s contraction mapping principle, while an existence result is established by using Leray–Schauder nonlinear alternative. Examples illustrating the main results are also constructed.

Fractional BVPs with strong time singularities and the limit properties of their solutions

2014 ◽  
Vol 12 (11) ◽  
Author(s):  
Svatoslav Staněk
Keyword(s):  
Boundary Conditions ◽  
Fractional Derivative ◽  
Caputo Fractional Derivative ◽  
Existence Result ◽  
Continuous Operator ◽  
Nonlinear Alternative ◽  
Time Singularities

AbstractIn the first part, we investigate the singular BVP $$\tfrac{d} {{dt}}^c D^\alpha u + (a/t)^c D^\alpha u = \mathcal{H}u$$, u(0) = A, u(1) = B, c D α u(t)|t=0 = 0, where $$\mathcal{H}$$ is a continuous operator, α ∈ (0, 1) and a < 0. Here, c D denotes the Caputo fractional derivative. The existence result is proved by the Leray-Schauder nonlinear alternative. The second part establishes the relations between solutions of the sequence of problems $$\tfrac{d} {{dt}}^c D^{\alpha _n } u + (a/t)^c D^{\alpha _n } u = f(t,u,^c D^{\beta _n } u)$$, u(0) = A, u(1) = B, $$\left. {^c D^{\alpha _n } u(t)} \right|_{t = 0} = 0$$ where a < 0, 0 < β n ≤ α n < 1, limn→∞ β n = 1, and solutions of u″+(a/t)u′ = f(t, u, u′) satisfying the boundary conditions u(0) = A, u(1) = B, u′(0) = 0.

Half-lives of spherical proton emitters within the framework of fractional calculus

2014 ◽  
Vol 23 (09) ◽  
pp. 1450044 ◽  
Author(s):  
Abdullah Engin Çalik ◽  
Hüseyin Şirin ◽  
Hüseyin Ertik ◽  
Buket Öder ◽  
Mürsel Şen
Keyword(s):  
Fractional Calculus ◽  
Fractional Derivative ◽  
Nuclear Structure ◽  
Caputo Fractional Derivative ◽  
Half Life ◽  
Nuclear Decay ◽  
Life Values ◽  
Derivative Order

In this paper, the half-life values of spherical proton emitters such as Sb , Tm , Lu , Ta , Re , Ir , Au , Tl and Bi have been calculated within the framework of fractional calculus. Nuclear decay equation, related to this phenomenon, has been resolved by using Caputo fractional derivative. The order of fractional derivative μ being considered is 0 < μ ≤ 1, and characterizes the fractality of time. Half-life values have been calculated equivalent with empirical ones. The dependence of fractional derivative order μ on the nuclear structure has also been investigated.

scholarly journals Approximation and application of the Riesz-Caputo fractional derivative of variable order with fixed memory

Meccanica ◽  
2021 ◽  
Author(s):  
Tomasz Blaszczyk ◽  
Krzysztof Bekus ◽  
Krzysztof Szajek ◽  
Wojciech Sumelka
Keyword(s):  
Differential Operator ◽  
Fractional Derivative ◽  
Rate Of Convergence ◽  
Continuum Mechanics ◽  
Caputo Fractional Derivative ◽  
Polynomial Interpolation ◽  
Piecewise Linear ◽  
Variable Order ◽  
Piecewise Constant ◽  
Quadratic Interpolation

AbstractIn this paper, the Riesz-Caputo fractional derivative of variable order with fixed memory is considered. The studied non-integer differential operator is approximated by means of modified basic rules of numerical integration. The three proposed methods are based on polynomial interpolation: piecewise constant, piecewise linear, and piecewise quadratic interpolation. The errors generated by the described methods and the experimental rate of convergence are reported. Finally, an application of the Riesz-Caputo fractional derivative of space-dependent order in continuum mechanics is depicted.

Sign in / Sign up

Export Citation Format

Share Document