Semi-supervised segmentation of lesion from breast ultrasound images with attentional generative adversarial network

2020 ◽  
Vol 189 ◽  
pp. 105275 ◽  
Author(s):  
Luyi Han ◽  
Yunzhi Huang ◽  
Haoran Dou ◽  
Shuai Wang ◽  
Sahar Ahamad ◽  
...  
Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 456 ◽  
Author(s):  
Tomoyuki Fujioka ◽  
Kazunori Kubota ◽  
Mio Mori ◽  
Yuka Kikuchi ◽  
Leona Katsuta ◽  
...  

We aimed to use generative adversarial network (GAN)-based anomaly detection to diagnose images of normal tissue, benign masses, or malignant masses on breast ultrasound. We retrospectively collected 531 normal breast ultrasound images from 69 patients. Data augmentation was performed and 6372 (531 × 12) images were available for training. Efficient GAN-based anomaly detection was used to construct a computational model to detect anomalous lesions in images and calculate abnormalities as an anomaly score. Images of 51 normal tissues, 48 benign masses, and 72 malignant masses were analyzed for the test data. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of this anomaly detection model were calculated. Malignant masses had significantly higher anomaly scores than benign masses (p < 0.001), and benign masses had significantly higher scores than normal tissues (p < 0.001). Our anomaly detection model had high sensitivities, specificities, and AUC values for distinguishing normal tissues from benign and malignant masses, with even greater values for distinguishing normal tissues from malignant masses. GAN-based anomaly detection shows high performance for the detection and diagnosis of anomalous lesions in breast ultrasound images.


2021 ◽  
Vol 15 (1) ◽  
pp. 71-77
Author(s):  
Dheeraj Kumar ◽  
Mayuri A. Mehta ◽  
Indranath Chatterjee

Introduction: Recent research on Generative Adversarial Networks (GANs) in the biomedical field has proven the effectiveness in generating synthetic images of different modalities. Ultrasound imaging is one of the primary imaging modalities for diagnosis in the medical domain. In this paper, we present an empirical analysis of the state-of-the-art Deep Convolutional Generative Adversarial Network (DCGAN) for generating synthetic ultrasound images. Aims: This work aims to explore the utilization of deep convolutional generative adversarial networks for the synthesis of ultrasound images and to leverage its capabilities. Background: Ultrasound imaging plays a vital role in healthcare for timely diagnosis and treatment. Increasing interest in automated medical image analysis for precise diagnosis has expanded the demand for a large number of ultrasound images. Generative adversarial networks have been proven beneficial for increasing the size of data by generating synthetic images. Objective: Our main purpose in generating synthetic ultrasound images is to produce a sufficient amount of ultrasound images with varying representations of a disease. Methods: DCGAN has been used to generate synthetic ultrasound images. It is trained on two ultrasound image datasets, namely, the common carotid artery dataset and nerve dataset, which are publicly available on Signal Processing Lab and Kaggle, respectively. Results: Results show that good quality synthetic ultrasound images are generated within 100 epochs of training of DCGAN. The quality of synthetic ultrasound images is evaluated using Mean Squared Error (MSE), Peak Signal-to-Noise Ratio (PSNR), and Structural Similarity Index Measure (SSIM). We have also presented some visual representations of the slices of generated images for qualitative comparison. Conclusion: Our empirical analysis reveals that synthetic ultrasound image generation using DCGAN is an efficient approach. Other: In future work, we plan to compare the quality of images generated through other adversarial methods such as conditional GAN, progressive GAN.


2017 ◽  
Author(s):  
Benjamin Sanchez-Lengeling ◽  
Carlos Outeiral ◽  
Gabriel L. Guimaraes ◽  
Alan Aspuru-Guzik

Molecular discovery seeks to generate chemical species tailored to very specific needs. In this paper, we present ORGANIC, a framework based on Objective-Reinforced Generative Adversarial Networks (ORGAN), capable of producing a distribution over molecular space that matches with a certain set of desirable metrics. This methodology combines two successful techniques from the machine learning community: a Generative Adversarial Network (GAN), to create non-repetitive sensible molecular species, and Reinforcement Learning (RL), to bias this generative distribution towards certain attributes. We explore several applications, from optimization of random physicochemical properties to candidates for drug discovery and organic photovoltaic material design.


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