Effect of fractal-shaped outer boundary of glioblastoma multiforme on drug delivery

2019 ◽  
Vol 178 ◽  
pp. 191-199 ◽  
Author(s):  
S.E. Samioti ◽  
L.Th. Benos ◽  
I.E. Sarris
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Outer Boundary

Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle Based Targeted Drug Delivery System

2020 ◽  
Vol 21 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Gautam Bhardwaj ◽  
Shikha Goswami ◽  
Rajiv Kumar Tonk ◽  
Ramesh K. Goyal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Drug Delivery System ◽  
Delivery System ◽  
Genetic Disorder ◽  
Drug Regimen ◽  
Brain Regions ◽  
Radio Therapy ◽  
Novel Drug ◽  
The Brain

: The Glioblastoma Multiforme (GBM; grade IV astrocytoma) exhort tumor of star-shaped glial cell in the brain. It is a fast-growing tumor that spreads to nearby brain regions specifically to cerebral hemispheres in frontal and temporal lobes. The etiology of GBM is unknown, but major risk factors are genetic disorder like neurofibromatosis and schwanomatosis which develop the tumor in the nervous system. The management of GBM with chemo-radio therapy leads to resistance and current drug regimen like Temozolomide (TMZ) is less efficacious. The reasons behind failure of drugs are due to DNA alkylation in cell cycle by enzyme DNA guanidase and mitochondrial dysfunction. Naturally occurring bio-active compounds from plants known as phytochemicals, serve as vital sources for anti-cancer drugs. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, podophyllotoxin analogs, camptothecin, curcumin, aloe emodin, quercetin, berberine e.t.c. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancers. However the challenges posed by the presence of BBB/BBTB to restrict passage of these phytochemicals, culminates in their low bioavailability and relative toxicity. In this review we integrated nanotech as novel drug delivery system to deliver phytochemicals from traditional medicine to the specific site within the brain for the management of GBM.

scholarly journals Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma

Nanoscale ◽  
2020 ◽  
Vol 12 (46) ◽  
pp. 23838-23850
Author(s):  
Giulia Brachi ◽  
Javier Ruiz-Ramírez ◽  
Prashant Dogra ◽  
Zhihui Wang ◽  
Vittorio Cristini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Intratumoral Injection ◽  
Embedded Nanoparticles ◽  
Intratumoral Drug Delivery

Intratumoral drug delivery is a promising approach for the treatment of glioblastoma multiforme (GBM).

scholarly journals Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 860
Author(s):  
Raneem Jnaidi ◽  
António José Almeida ◽  
Lídia M. Gonçalves
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Tumor Location ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Solid Lipid

Glioblastoma multiforme (GBM) is the most common and malignant type of brain tumor. In fact, tumor recurrence usually appears a few months after surgical resection and chemotherapy, mainly due to many factors that make GBM treatment a real challenge, such as tumor location, heterogeneity, presence of the blood-brain barrier (BBB), and others. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) represent the most promising carriers for therapeutics delivery into the central nervous system (CNS) owing to their inherent ability to cross the BBB. In this review, we present the main challenges in GBM treatment, a description of SLNs and NLCs and their valuable role as drug carriers in GBM treatment, and finally, a detailed description of all modification strategies that aim to change composition of SLNs and NLCs to enhance treatment outcomes. This includes modification of SLNs and NLCs to improve crossing the BBB, reduced GBM cell resistance, target GBM cells selectively minimizing side effects, and modification strategies to enhance SLNs and NLCs nose-to-brain delivery. Finally, future perspectives on their use are also be discussed, to provide insight about all strategies with SLNs and NLCs formulation that could result in drug delivery systems for GBM treatment with highly effective theraputic and minimum undesirable effects.

scholarly journals Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme

2020 ◽  
Vol 2 (10) ◽  
pp. 4498-4509
Author(s):  
Majed Alghamdi ◽  
Filippo Chierchini ◽  
Dimitri Eigel ◽  
Christian Taplan ◽  
Thomas Miles ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Glioblastoma Multiforme ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Soft and flexible poly(ethylene glycol)-based nanotubes load doxorubicin for controlled release to glioblastoma multiforme.

scholarly journals Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme

Drug Research ◽  
2020 ◽  
Author(s):  
Md. Habban Akhter ◽  
Md. Rizwanullah ◽  
Javed Ahmad ◽  
Saima Amin ◽  
Mohammad Zaki Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Targeted Delivery ◽  
Inorganic Nanoparticles ◽  
Therapeutic Approaches ◽  
The Stability ◽  
And Control ◽  
Plasma Half Life ◽  
Nanoparticulate Systems ◽  
Proteins And Peptides

AbstractGlioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). Therefore, novel therapeutic approaches are needed. Nanoparticles are one of the highly efficient drug delivery systems for a variety of chemotherapeutics that have gained massive attention from the last three decades. Perfectly designed nanoparticles have the ability to cross BBB and BTB and precisely deliver the chemotherapeutics to GBM tissue/cells. Nanoparticles can encapsulate both hydrophilic and lipophilic drugs, genes, proteins, and peptides, increase the stability of drugs by protecting them from degradation, improve plasma half-life, reduce adverse effects and control the release of drugs/genes at the desired site. This review focussed on the different signaling pathways altered in GBM cells to understand the rationale behind selecting new therapeutic targets, challenges in the drug delivery to the GBM, various transport routes in brain delivery, and recent advances in targeted delivery of different drug and gene loaded various lipidic, polymeric and inorganic nanoparticles in the effective management of GBM.

scholarly journals Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme

Materials ◽  
2018 ◽  
Vol 11 (5) ◽  
pp. 779 ◽  
Author(s):  
L. Nam ◽  
C. Coll ◽  
L. Erthal ◽  
C. de la Torre ◽  
D. Serrano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Localized Treatment

scholarly journals Intratumoral Therapy of Glioblastoma Multiforme Using Genetically Engineered Transferrin for Drug Delivery

2010 ◽  
Vol 70 (11) ◽  
pp. 4520-4527 ◽  
Author(s):  
Dennis J. Yoon ◽  
Byron H. Kwan ◽  
Felix C. Chao ◽  
Theodore P. Nicolaides ◽  
Joanna J. Phillips ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Genetically Engineered ◽  
Intratumoral Therapy

scholarly journals Current Perspective on the Natural Compounds and Drug Delivery Techniques in Glioblastoma Multiforme

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2765
Author(s):  
Tapan Behl ◽  
Aditi Sharma ◽  
Lalit Sharma ◽  
Aayush Sehgal ◽  
Sukhbir Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Natural Compounds ◽  
Current Standard ◽  
Current Perspective ◽  
Effective Therapeutic Strategy ◽  
Cellular Pathways ◽  
Improve Patient ◽  
Delivery Techniques

Glioblastoma multiforme (GBM) is one of the debilitating brain tumors, being associated with extremely poor prognosis and short median patient survival. GBM is associated with complex pathogenesis with alterations in various cellular signaling events, that participate in cell proliferation and survival. The impairment in cellular redox pathways leads to tumorigenesis. The current standard pharmacological regimen available for glioblastomas, such as radiotherapy and surgical resection following treatment with chemotherapeutic drug temozolomide, remains fatal, due to drug resistance, metastasis and tumor recurrence. Thus, the demand for an effective therapeutic strategy for GBM remains elusive. Hopefully, novel products from natural compounds are suggested as possible solutions. They protect glial cells by reducing oxidative stress and neuroinflammation, inhibiting proliferation, inducing apoptosis, inhibiting pro-oncogene events and intensifying the potent anti-tumor therapies. Targeting aberrant cellular pathways in the amelioration of GBM could promote the development of new therapeutic options that improve patient quality of life and extend survival. Consequently, our review emphasizes several natural compounds in GBM treatment. We also assessed the potential of drug delivery techniques such as nanoparticles, Gliadel wafers and drug delivery using cellular carriers which could lead to a novel path for the obliteration of GBM.

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