scholarly journals Recent computational methods for white blood cell nuclei segmentation: A comparative study

2019 ◽  
Vol 173 ◽  
pp. 1-14 ◽  
Author(s):  
Alan R. Andrade ◽  
Luis H.S. Vogado ◽  
Rodrigo de M.S. Veras ◽  
Romuere R.V. Silva ◽  
Flávio H.D. Araujo ◽  
...  
Keyword(s):  
Blood Cell ◽  
Comparative Study ◽  
Computational Methods ◽  
White Blood Cell ◽  
Cell Nuclei ◽  
Nuclei Segmentation

scholarly journals Experimental infections of domestic rabbits (oryctolagus cuniculus) with Trypanosoma brucei and Trypanosma congolense: A comparative study

2021 ◽  
Vol 31 (1) ◽  
pp. 100-111
Author(s):  
R. C. Ezeokonkwo ◽  
W. E. Agu
Keyword(s):  
Blood Cell ◽  
Comparative Study ◽  
Haemoglobin Level ◽  
Cell Count ◽  
Trypanosoma Brucei ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Oryctolagus Cuniculus ◽  
Blood Cell Count ◽  
Domestic Rabbits

Comparative study of single infections of domestic rabbits (Oryctolagus cuniculus) with Nigerian isolates of Trypanosoma brucei (Gboko strain), and Trypanosoma congolesense (Binchi strain) was carried out in the laboratory for clinical and haematological effects. Eighteen rabbits of 10-14 weeks old weighing between 600- 1200 grams were used for the study. The rabbits of both sexes were randomly selected and divided into groups. The level of infection was studied by determining red blood cell (RBC) count, haemoglobin estimation, total and differential white blood cell (WBC) count, changes in body weight, mortality, rectal temperature  changes and other clinical signs of trypanosomiasis. There was significant reduction (P<0.001) in the total red blood cell counts and haemoglobin level in the rabbits when compared to the control rabbits with the effect being more pronounced in those rabbits infected with T. congolense. The white blood cell count was also highest in those rabbits infected with T. congolense. Both parasites produced similar clinical symptoms which included weight loss, unthriftiness, anorexia, fever, paleness of mucous membrane, and oedema of the facial region. One death was recorded in each of the infected group. Possible reasons for the significant differences in the total red blood cell count, haemoglobin level, and total whitre blood cell count are discussed.

scholarly journals Comparative Study on Automated Cell Nuclei Segmentation Methods for Cytology Pleural Effusion Images

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Khin Yadanar Win ◽  
Somsak Choomchuay ◽  
Kazuhiko Hamamoto ◽  
Manasanan Raveesunthornkiat
Keyword(s):  
Pleural Effusion ◽  
Comparative Study ◽  
Performance Metrics ◽  
Mean Shift ◽  
Automated Analysis ◽  
Cell Nuclei ◽  
Detection Rates ◽  
Nuclei Segmentation ◽  
Segmentation Methods ◽  
Aided Diagnosis

Automated cell nuclei segmentation is the most crucial step toward the implementation of a computer-aided diagnosis system for cancer cells. Studies on the automated analysis of cytology pleural effusion images are few because of the lack of reliable cell nuclei segmentation methods. Therefore, this paper presents a comparative study of twelve nuclei segmentation methods for cytology pleural effusion images. Each method involves three main steps: preprocessing, segmentation, and postprocessing. The preprocessing and segmentation stages help enhancing the image quality and extracting the nuclei regions from the rest of the image, respectively. The postprocessing stage helps in refining the segmented nuclei and removing false findings. The segmentation methods are quantitatively evaluated for 35 cytology images of pleural effusion by computing five performance metrics. The evaluation results show that the segmentation performances of the Otsu, k-means, mean shift, Chan–Vese, and graph cut methods are 94, 94, 95, 94, and 93%, respectively, with high abnormal nuclei detection rates. The average computational times per image are 1.08, 36.62, 50.18, 330, and 44.03 seconds, respectively. The findings of this study will be useful for current and potential future studies on cytology images of pleural effusion.

Statistical pattern analysis of white blood cell nuclei morphometry

2010 ◽  
Author(s):  
Madhumala Ghosh ◽  
Devkumar Das ◽  
Subhodip Mandal ◽  
Chandan Chakraborty ◽  
Mallika Pala ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Pattern Analysis ◽  
Cell Nuclei ◽  
Statistical Pattern

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

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