A probabilistic model for reducing medication errors: A sensitivity analysis using Electronic Health Records data

2019 ◽  
Vol 170 ◽  
pp. 31-38
Author(s):  
Chu-Ya Huang ◽  
Phung-Anh Nguyen ◽  
Hsuan-Chia Yang ◽  
Md Mohaimenul Islam ◽  
Chia-Wei Liang ◽  
...  
2015 ◽  
Vol 5 (5) ◽  
pp. 672-704 ◽  
Author(s):  
Naseem Qureshi ◽  
Dalal Al-Dossari ◽  
Ibrahim Al-Zaagi ◽  
Abdullah Al-Bedah ◽  
Abdulrahman Abudalli ◽  
...  

2016 ◽  
Vol 25 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Sumana Alex ◽  
Ayne B. Adenew ◽  
Cherinne Arundel ◽  
David D. Maron ◽  
Jennifer C. Kerns

2018 ◽  
Author(s):  
Lauren J. Beesley ◽  
Lars G. Fritsche ◽  
Bhramar Mukherjee

AbstractLarge-scale agnostic association analyses based on existing observational health care databases such as electronic health records have been a topic of increasing interest in the scientific community. However, particular challenges of non-probability sampling and phenotype misclassification associated with the use of these data sources are often ignored in standard analyses. In general, the extent of the bias that may be introduced by ignoring these factors is unknown. In this paper, we develop a statistical framework for characterizing the degree of bias expected in association studies based on electronic health records when disease status misclassification and the sampling mechanism are ignored. Through a sensitivity analysis type approach, this framework can be used to obtain plausible values for parameters of interest given results obtained from standard naive analysis methods under varying degree of misclassification and sampling biases. We develop an online tool for performing this sensitivity analysis in some special cases that occur frequently. Simulations demonstrate promising properties of the proposed way of characterizing biases. We apply our approach to study bias in genetic association studies using data from the Michigan Genomics Initiative, a longitudinal biorepository effort within Michigan Medicine.


2016 ◽  
Vol 34 (2) ◽  
pp. 163-165 ◽  
Author(s):  
William B. Ventres ◽  
Richard M. Frankel

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