A semi-automatic algorithm for measurement of basement membrane thickness in kidneys in electron microscopy images

2010 ◽  
Vol 97 (3) ◽  
pp. 223-231 ◽  
Author(s):  
Hai-Shan Wu ◽  
Steven Dikman ◽  
Joan Gil
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Membrane Thickness ◽  
Basement Membrane Thickness ◽  
Microscopy Images ◽  
Automatic Algorithm

Microvascular Response to Tissue Injury and Capillary Ultrastructure in the Foot Skin of Type I Diabetic Patients

1995 ◽  
Vol 89 (5) ◽  
pp. 467-474 ◽  
Author(s):  
G. Rayman ◽  
R. A. Malik ◽  
A. K. Sharma ◽  
J. L. Day
Keyword(s):  
Basement Membrane ◽  
Light And Electron Microscopy ◽  
Microvascular Blood Flow ◽  
Diabetic Patients ◽  
Membrane Thickness ◽  
Type I ◽  
Basement Membrane Thickness ◽  
Doppler Flowmetry ◽  
Hyperaemic Response ◽  
Capillary Size

1. Microvascular blood flow responses to injury and capillary ultrastructure were assessed by laser Doppler flowmetry and detailed light and electron microscopy respectively in skin biopsied from 28 patients with insulin-dependent diabetes and 17 control subjects. 2. The hyperaemic response induced by biopsy (P < 0.001) and heating to 44°C (P < 0.001) was significantly lower in the diabetic patients and showed progressive impairment with the severity of complications (P < 0.001). 3. Skin capillary basement membrane thickness was significantly increased in the diabetic patients (P < 0.001) and also increased with the severity of complications (P < 0.002). Both the luminal area (P < 0.001) and the endothelial cell outer perimeter (P < 0.002), measures of luminal and capillary size, respectively, were significantly reduced in all diabetic patients. 4. Basement membrane thickness was related significantly to the impaired hyperaemic response to both biopsy (P < 0.01) and thermal injury (P < 0.01). 5. Our findings support the hypothesis that structural abnormalities, which are characterized by an early reduction in capillary size and later thickening of basement membrane, form an important mechanism for the impaired hyperaemic response in diabetic patients.

The Relationship of Reticular Basement Membrane Thickness to Airway Wall Remodeling in Asthma

2002 ◽  
Vol 166 (12) ◽  
pp. 1590-1595 ◽  
Author(s):  
Alan L. James ◽  
Peta S. Maxwell ◽  
Gladys Pearce-Pinto ◽  
John G. Elliot ◽  
Neil G. Carroll
Keyword(s):  
Basement Membrane ◽  
Membrane Thickness ◽  
Airway Wall ◽  
Basement Membrane Thickness ◽  
Relationship Of ◽  
The Relationship

Dependency of Muscle Capillary Basement Membrane Thickness on the Duration of Diabetes

Diabetes Care ◽  
1979 ◽  
Vol 2 (6) ◽  
pp. 472-478 ◽  
Author(s):  
E. A. Siess ◽  
H. E. Nathke ◽  
T. Dexel ◽  
M. Haslbeck ◽  
H. Mehnert ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Membrane Thickness ◽  
Basement Membrane Thickness ◽  
Duration Of Diabetes ◽  
Capillary Basement Membrane

Influences of physical conditioning and deconditioning on coronary vasculature of dogs

1978 ◽  
Vol 45 (4) ◽  
pp. 619-625 ◽  
Author(s):  
H. L. Wyatt ◽  
J. Mitchell
Keyword(s):  
Basement Membrane ◽  
Capillary Density ◽  
Cross Sectional Area ◽  
Membrane Thickness ◽  
Physical Conditioning ◽  
Sectional Area ◽  
Circumflex Artery ◽  
Cross Sectional ◽  
Coronary Vasculature ◽  
Basement Membrane Thickness

To investigate the effects of physical conditioning and deconditioning on the coronary vasculature, eight dogs were exercised by treadmill running. Five dogs were deconditioned by confinement in cages following the conditioning period. A technique was developed and validated for measuring circumflex coronary artery diameter from magnified projections of standardized coronary angiograms. Myocardial capillary density, perimeter, and basement membrane thickness were determined from electron microscopy of serial ventricular septal biopsy samples. Physical conditioning caused a small but statistically significant increase in cross-sectional area of the circumflex artery. Although physical conditioning caused no statistically significant changes in the myocardial capillaries, trends were apparent for increases in density and perimeter of myocardial capillaries and a decrease in basement membrane thickness. Physical deconditioning caused statistically significant reductions in cross-sectional area of the circumflex artery and in myocardial capillary density but little change in perimeter or basement membrane thickness of myocardial capillaries. The results suggest that physical conditioning may be associated with an improvement in coronary vascular capacity which may regress rapidly with deconditioning.

BASEMENT MEMBRANE THICKNESS OF RECTAL CAPILLARIES IN DIABETES

The Lancet ◽  
1973 ◽  
Vol 301 (7807) ◽  
pp. 837 ◽  
Author(s):  
N.R. Farid ◽  
E. Wilkinson ◽  
F.L. Constable ◽  
J. Anderson
Keyword(s):  
Basement Membrane ◽  
Membrane Thickness ◽  
Basement Membrane Thickness

Sulfonylurea-induced decrease of muscle capillary basement membrane thickness in diabetes

1988 ◽  
Vol 5 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Rafael A. Camerini-Davalos ◽  
Carlos A. Velasco ◽  
Marvin Glasser ◽  
J.M.B. Bloodworth
Keyword(s):  
Basement Membrane ◽  
Membrane Thickness ◽  
Basement Membrane Thickness ◽  
Capillary Basement Membrane
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