Pre-therapeutic nutritional assessment for predicting severe adverse events in patients with head and neck cancer treated by radiotherapy

2017 ◽  
Vol 36 (6) ◽  
pp. 1681-1685 ◽  
Author(s):  
Takeyuki Kono ◽  
Koji Sakamoto ◽  
Seiichi Shinden ◽  
Kaoru Ogawa
Keyword(s):  
Head And Neck Cancer ◽  
Adverse Events ◽  
Head And Neck ◽  
Neck Cancer ◽  
Nutritional Assessment ◽  
Severe Adverse Events

Effect of Epoetin Alfa on Survival and Cancer Treatment–Related Anemia and Fatigue in Patients Receiving Radical Radiotherapy With Curative Intent for Head and Neck Cancer

2009 ◽  
Vol 27 (34) ◽  
pp. 5751-5756 ◽  
Author(s):  
Peter J. Hoskin ◽  
Martin Robinson ◽  
Nicholas Slevin ◽  
David Morgan ◽  
Kevin Harrington ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Adverse Events ◽  
Cancer Treatment ◽  
Head And Neck ◽  
Neck Cancer ◽  
Functional Assessment ◽  
Radical Radiotherapy ◽  
Epoetin Alfa ◽  
Local Tumor ◽  
Curative Intent

Purpose To evaluate the effect of epoetin alfa on local disease-free survival (DFS), overall survival (OS), and cancer treatment–related anemia and fatigue in patients with head and neck cancer receiving radical radiotherapy with curative intent. Patients and Methods Patients (N = 301) with hemoglobin (Hb) less than 15 g/dL were randomly assigned in a ratio of 1:1 to receive radiotherapy plus epoetin alfa (10,000 U subcutaneously [SC] three times weekly if baseline Hb was < 12.5 g/dL; 4,000 U SC three times weekly if baseline Hb ≥ 12.5 g/dL) or radiotherapy alone. Hb levels were monitored weekly. The primary end point was local DFS, defined as the time from random assignment to local disease recurrence or death. Secondary efficacy end points included OS, local tumor response, and local tumor control. Patients were followed at 1, 4, 8, and 12 weeks postradiotherapy and annually for 5 years. Cancer treatment–related anemia and fatigue were evaluated with the Functional Assessment of Cancer Therapy-Anemia and Functional Assessment of Cancer Therapy-Head and Neck. Adverse events were recorded up to 12 weeks postradiotherapy. Results Hb levels increased from baseline with epoetin alfa. The median duration of local DFS was not statistically different between groups (observation, 35.42 months; epoetin alfa, 31.47 months; hazard ratio, 1.04; 95% CI, 0.77 to 1.41). Groups did not significantly differ in DFS, OS, tumor outcomes, or cancer treatment–related anemia or fatigue. No new or unexpected adverse events were observed. Conclusion Addition of epoetin alfa to radical radiotherapy did not affect survival, tumor outcomes, anemia, or fatigue positively or negatively in patients with head and neck cancer.

Clinical outcome in recurrent and/or metastatic head and neck cancer patients after discontinuation of nivolumab monotherapy due to immune-related adverse events

2020 ◽  
Vol 140 (12) ◽  
pp. 1043-1048
Author(s):  
Ryuji Yasumatsu ◽  
Mioko Matsuo ◽  
Takahiro Wakasaki ◽  
Muneyuki Masuda ◽  
Toranoshin Takeuchi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Clinical Outcome ◽  
Adverse Events ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer

scholarly journals Hearing evaluation of patients with head and neck cancer: Comparison of Common Terminology Criteria for Adverse Events, Brock and Chang adverse event criteria in patients receiving cisplatin

Head & Neck ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 1102-1107 ◽  
Author(s):  
A. Dimitrios Colevas ◽  
Ruth R. Lira ◽  
Electra A. Colevas ◽  
Philip W. Lavori ◽  
Cato Chan ◽  
...  
Keyword(s):  
Adverse Event ◽  
Head And Neck Cancer ◽  
Adverse Events ◽  
Head And Neck ◽  
Neck Cancer ◽  
Hearing Evaluation

Nutritional assessment in head and neck cancer patients

2006 ◽  
Vol 38 ◽  
pp. S218
Author(s):  
D. Assisi ◽  
I. Sanchez Mete ◽  
L. Marucci ◽  
I. Schiavetto ◽  
M.L. Alfonsi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Nutritional Assessment

Serious immune‐related adverse events in patients with head and neck cancer after checkpoint blockade: Systematic review

Head & Neck ◽  
2019 ◽  
Vol 41 (11) ◽  
pp. 4036-4050 ◽  
Author(s):  
Mohsin Shah ◽  
Mona K. Jomaa ◽  
Renata Ferrarotto ◽  
Sai‐Ching J. Yeung ◽  
Ehab Y. Hanna ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Adverse Events ◽  
Head And Neck ◽  
Neck Cancer ◽  
Checkpoint Blockade

Hand-grip strength does not correlate with treatment-related weight loss in patients with head and neck cancer

2015 ◽  
Vol 129 (7) ◽  
pp. 706-709 ◽  
Author(s):  
B Cosway ◽  
M Easby ◽  
S Covington ◽  
I Bowe ◽  
V Paleri
Keyword(s):  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Grip Strength ◽  
Neck Cancer ◽  
Nutritional Assessment ◽  
Hand Grip Strength ◽  
Prospective Audit ◽  
Hand Grip ◽  
Routine Assessment

AbstractBackground:Hand-grip strength has been shown to be a reliable predictor of health outcomes. However, evidence supporting its use as an indicator of nutritional status is inconsistent. This study investigated its use in monitoring nutritional status in patients with head and neck cancer.Methods:A prospective audit of patients treated for head and neck cancer was undertaken at four centres over a three-month period in 2009. Nutritional outcomes were collected at 3, 6 and 12 months, and the data were statistically analysed.Results:Data from 114 patients showed that mean weight, but not hand-grip strength, fell significantly at 3, 6 and 12 months post-treatment (p < 0.003 vs p < 0.126).Conclusion:A fall in weight does not coincide with a drop in hand-grip strength in patients receiving treatment for head and neck cancer. Hand-grip strength may therefore not be of benefit in the nutritional assessment of these patients and should not be part of routine assessment.

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