Early Relapse After Autologous Transplant Is Associated With Very Poor Survival and Identifies an Ultra-High-Risk Group of Patients With Myeloma

2020 ◽  
Vol 20 (7) ◽  
pp. 445-452 ◽  
Author(s):  
Efstathios Kastritis ◽  
Maria Roussou ◽  
Evangelos Eleutherakis-Papaiakovou ◽  
Maria Gavriatopoulou ◽  
Magdalini Migkou ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Group ◽  
High Risk Group ◽  
Poor Survival ◽  
Early Relapse ◽  
Autologous Transplant ◽  
Ultra High Risk

Larger left hippocampal volume predicts transition to psychosis in an ultra high-risk group

2000 ◽  
Vol 41 (1) ◽  
pp. 117 ◽  
Author(s):  
D. Velakoulis ◽  
L. Phillips ◽  
P.D. McGorry ◽  
A. Yung ◽  
H.P. Yuen ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Group ◽  
Hippocampal Volume ◽  
High Risk Group ◽  
Ultra High Risk

scholarly journals Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness

2003 ◽  
Vol 182 (6) ◽  
pp. 518-524 ◽  
Author(s):  
Murat Yücel ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Geoffrey W. Stuart ◽  
Deidre J. Smith ◽  
...  
Keyword(s):  
High Risk ◽  
Anterior Cingulate Cortex ◽  
Risk Group ◽  
Subsequent Development ◽  
Cingulate Cortex ◽  
High Risk Group ◽  
Anterior Cingulate ◽  
Psychotic Illness ◽  
Ultra High Risk ◽  
Morphological Anomalies

BackgroundThe anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder.AimsTo examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness.MethodMagnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features.ResultsCompared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness.ConclusionsAlthough ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.

scholarly journals Ultra-High-Risk Group of Multiple Myeloma: A Real-World Study Based On Two Different Prognostic Evaluation Systems

2021 ◽  
Author(s):  
Jian-Nan Ye ◽  
Ke-Wa Ma ◽  
Yong-Qin Cao ◽  
Chao Sun ◽  
Xin Zhou
Keyword(s):  
Multiple Myeloma ◽  
High Risk ◽  
Risk Group ◽  
High Risk Group ◽  
Prognostic Evaluation ◽  
Evaluation Systems ◽  
High Risk Factors ◽  
Two Systems ◽  
Ultra High Risk ◽  
Research Alliance

Abstract Recently, two prognostic evaluation systems based on different angles, UK Myeloma Research Alliance proposed UK Myeloma Research Alliance Risk Profile(MRP) and chinese inflammatory prognostic scoring index(IPSI), have shown prognostic differences in newly diagnosed multiple myeloma(MM) patients without transplantation. However, there is no relevant research on whether there is a difference in the evaluation of the two systems. Here, we used these two systems to evaluate the prognosis of 160 patients with MM based on bortezomib without transplantation from January 2007 to June 2018. It was found that the evaluation of patients at medium and low risk was similar, but in the high-risk group of MRP, IPSI could be further stratified, and in the high-risk group of IPSI, MRP could also be further stratified. It is suggested that myeloma patients with high risk factors of MRP and IPSI are ultra high risk patients with poor prognosis.

Genetically predisposed offspring with schizotypal features: An ultra high-risk group for schizophrenia?

2006 ◽  
Vol 30 (2) ◽  
pp. 230-238 ◽  
Author(s):  
Vaibhav A. Diwadkar ◽  
Debra M. Montrose ◽  
Diana Dworakowski ◽  
John A. Sweeney ◽  
Matcheri S. Keshavan
Keyword(s):  
High Risk ◽  
Risk Group ◽  
High Risk Group ◽  
Ultra High Risk

scholarly journals Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

2017 ◽  
Vol 7 (2) ◽  
pp. e523-e523 ◽  
Author(s):  
P Richter-Pechańska ◽  
J B Kunz ◽  
J Hof ◽  
M Zimmermann ◽  
T Rausch ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Group ◽  
Lymphoblastic Leukemia ◽  
High Risk Group ◽  
Ultra High Risk

Cannabis Use is Not Associated With the Development of Psychosis in an ‘Ultra’ High-Risk Group

2002 ◽  
Vol 36 (6) ◽  
pp. 800-806 ◽  
Author(s):  
Lisa J Phillips ◽  
Christina Curry ◽  
Alison R Yung ◽  
Hok Pan Yuen ◽  
Steven Adlard ◽  
...  
Keyword(s):  
Risk Factor ◽  
High Risk ◽  
Psychotic Disorder ◽  
Risk Group ◽  
High Risk Group ◽  
Cannabis Use ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Ultra High Risk

Background: The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis. Method: The ‘ultra’ high risk cohort was identified by the presence of subthreshold psychotic symptoms, or a combination of first-degree relative with a psychotic disorder and recent functional decline. Thirty-two per cent of the cohort developed an acute psychotic episode over the 12-month period after recruitment. As a component of a larger research study, the level of cannabis use by participants in the year prior to enrolment in the study was assessed at intake. Results: Cannabis use or dependence in the year prior to recruitment to this study was not associated with a heightened risk of developing psychosis over the following 12-month period and therefore did not appear to contribute to the onset of a psychotic disorder. Conclusion: The results of this study suggest that cannabis use may not play an integral role in the development of psychosis in a high-risk group. While this study does not support a role for cannabis in the development of first-episode psychosis, we cannot conclude that cannabis use should be completely ignored as a candidate risk factor for onset of psychosis. A number of weaknesses of the study (the low level of cannabis use in the current sample, the lack of monitoring of cannabis use after intake) suggest that it may be premature to dismiss cannabis use as a risk factor for the development of psychosis and further research is urged in this area.

scholarly journals Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort

2016 ◽  
Vol 115 (4) ◽  
pp. 480-489 ◽  
Author(s):  
Irene Tadeo ◽  
Ana P Berbegall ◽  
Victoria Castel ◽  
Purificación García-Miguel ◽  
Robert Callaghan ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
High Risk ◽  
Risk Group ◽  
High Risk Patient ◽  
High Risk Group ◽  
Risk Patient ◽  
Matrix Composition ◽  
Patient Cohort ◽  
Ultra High Risk

scholarly journals The Combination of MRD and Copy Number Alterations (CNAs) Defines an Ultra-High Risk Group of Children with Primary T-Lymphoblastic Leukemia (T-ALL)

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2911-2911
Author(s):  
Joachim B. Kunz ◽  
Julia Seemann ◽  
Martin Zimmermann ◽  
Paulina Richter-Pechanska ◽  
Obul Reddy Bandapalli ◽  
...  
Keyword(s):  
High Risk ◽  
Candidate Genes ◽  
Risk Group ◽  
Risk Groups ◽  
High Risk Group ◽  
Copy Number Alterations ◽  
Ultra High Risk ◽  
Cdkn2a Deletion ◽  
Probe Set ◽  
Risk Of Relapse

Abstract As relapses in precursor T-ALL are frequently refractory to treatment, patients at high risk of relapse need to be identified and treated with intensified or novel regimens. Because minimal residual disease (MRD) assessment identifies patients at high risk only after induction treatment has been completed, there is an urgent need for genetic markers that allow for early risk stratification. We aimed at identifying such markers by analyzing a cohort of patients treated by ALL BFM 2000 and AIEOP-BFM ALL 2009 protocols for CNAs in both established leukemia driver genes and in a set of nine novel candidate genes that had been found to be frequently affected by gene panel sequencing. We analyzed bone marrow DNA of a large cohort of children with T-ALL for copy number alterations (CNA) by multiplex ligation dependent probe amplification (MLPA) using the commercially available probe set P383 (MRC Holland) and a custom made probe set targeting additional 9 genes (STAT5B, CNOT3, CNOT6, CTCF, ABCA5, PDGFRB, MYC, PTK2B, AKT1). We correlated the occurrence of these CNAs with risk of relapse and found that none of the CNAs listed in tables 1 and 2 as a single alteration predicted the risk of relapse in any risk group. By contrast, the combination of CNAs can define risk signatures. Specifically, we found the frequently linked deletions of CDKN2A and MLLT3 on chromosome 9p21.3 to have distinct effects: While biallelic CDKN2A-deletions increase the risk of relapse (Hazard ratio 2.1, p(χ)=0.049), this effect is counteracted by deletions of MLLT3, which reduce the risk of relapse (hazard ratio 0.35, p(χ)=0.031). Consequently, a combination of CDKN2A and MLLT3 deletions, together with activating mutations of NOTCH1, defines three risk groups in the German cohort of 209 patients treated in the intermediate and high risk groups of the ALL BFM 2000 protocol: Patients that carry both a NOTCH1 mutation and an MLLT3 deletion, but not a biallelic CDKN2A deletion, have a 5 year cumulative incidence of relapse (CIR) of 3% (1/29), whereas patients with biallelic CDKN2A deletion without MLLT3 deletion have a 5 year CIR of 26% (20/78; p=0.0057). All remaining patients have a 5 year CIR of 10 % (10/102). Notably, this risk signature might be highly dependent on the treatment context, because it predicted risk neither in 119 AIEOP-BFM 2009 patients treated in Czech Republic and Germany nor in 80 ALL BFM 2000 patients treated in Austria. We next considered the MRD-defined high-risk (HR) group of the BFM 2000 and AIEOP-BFM 2009 protocols consisting of 37 patients. At least one of the 9 CNAs listed in table 2 was detected in 64 of 376 patients of whom a complete set of clinical data were available and in 11 of 37 HR-patients (p=0.04). The presence of any of these 9 CNAs splits the HR group in a smaller "ultra-high risk group" with a 5 year CIR of 82% (8/11) and a larger group of patients with a 5 year CIR of only 24% (6/26) (p(Gray)=0.005). Neither was there an effect in MRD-MR patients nor in patients who were HR defined by prednisone-poor-response only. It must be noted that the deletions and amplifications shown in table 2 are part of large CNAs. Therefore, the indicated genes do not necessarily define risk per se but may represent markers for other changes with functional relevance or may indicate a more general genomic instability. We conclude that complementing MRD risk parameters with an analysis of common CNAs refines the current risk stratification and may identify an ultra-high risk group of children with T-ALL, who are candidates for experimental treatment even in primary disease. Table 1 Frequency of known and functional CNAs detected by P383 in BFM 2000 and BFM 2009 T-ALL patients Table 1. Frequency of known and functional CNAs detected by P383 in BFM 2000 and BFM 2009 T-ALL patients Table 2 Frequency of CNA defined by novel candidate genes in BFM 2000 and 2009 patients Table 2. Frequency of CNA defined by novel candidate genes in BFM 2000 and 2009 patients Disclosures No relevant conflicts of interest to declare.

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