Impact of Chromosome 6q Deletions in Multiple Myeloma and Waldenström’s Macroglobulinemia by Next Generation RNA Sequencing

2019 ◽  
Vol 19 (10) ◽  
pp. e39
Author(s):  
Maria Luisa Guerrera ◽  
Cristina Jimenez ◽  
Gloria Chan ◽  
Lian Xu ◽  
Amanda Kofides ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Rna Sequencing ◽  
Next Generation ◽  
Waldenström’S Macroglobulinemia ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

CD4+T cells in chronic autoantigenic stimulation in MGUS, multiple myeloma and Waldenström's macroglobulinemia

2015 ◽  
Vol 137 (5) ◽  
pp. 1076-1084 ◽  
Author(s):  
Frank Neumann ◽  
Michael Pfreundschuh ◽  
Klaus D. Preuss ◽  
Claudia Schormann ◽  
Carsten Zwick ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
T Cells ◽  
Cd4 T Cells ◽  
Waldenström’S Macroglobulinemia ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

scholarly journals Poor Correlation between Pneumococcal IgG and IgM Titers and Opsonophagocytic Activity in Vaccinated Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia

2016 ◽  
Vol 23 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Johanna Karlsson ◽  
Lucy Roalfe ◽  
Harriet Hogevik ◽  
Marta Zancolli ◽  
Björn Andréasson ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Elderly Subjects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Waldenström’S Macroglobulinemia ◽  
Control Subjects ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

ABSTRACTPatients with multiple myeloma and other B cell disorders respond poorly to pneumococcal vaccination. Vaccine responsiveness is commonly determined by measuring pneumococcal serotype-specific antibodies by enzyme-linked immunosorbent assay (ELISA), by a functional opsonophagocytosis assay (OPA), or by both assays. We compared the two methods in vaccinated elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance (MGUS). Postvaccination sera from 45 patients (n= 15 from each patient group) and 15 control subjects were analyzed by multiplexed OPA for pneumococcal serotypes 4, 6B, 14, and 23F, and the results were compared to IgG and IgM antibody titers measured by ELISA. While there were significant correlations between pneumococcal OPA and IgG titers for all serotypes among the control subjects (correlation coefficients [r] between 0.51 and 0.85), no significant correlations were seen for any of the investigated serotypes in the myeloma group (r= −0.18 to 0.21) or in the group with Waldenstrom's macroglobulinemia (borderline significant correlations for 2 of 4 serotypes). The MGUS group resembled the control group by having good agreement between the two test methods for 3 of 4 serotypes (r= 0.53 to 0.80). Pneumococcal postvaccination IgM titers were very low in the myeloma patients compared to the other groups and did not correlate with the OPA results. To summarize, our data indicate that ELISA measurements may overestimate antipneumococcal immunity in elderly subjects with B cell malignancies and that a functional antibody test should be used specifically for myeloma and Waldenstrom's macroglobulinemia patients.

Calorimetric markers for monitoring of multiple myeloma and Waldenström’s macroglobulinemia patients

2018 ◽  
Vol 47 (5) ◽  
pp. 549-559 ◽  
Author(s):  
Svetla Todinova ◽  
Sashka Krumova ◽  
Avgustina Danailova ◽  
Violeta Petkova ◽  
Margarita Guenova ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Waldenström’S Macroglobulinemia ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia
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