1.20 Some Features of Gene Repertoire of IGHV/D/J Rearrangements in Chronic Lymphocytic Leukemia Patients Exposed to Ionizing Radiation due to the Chernobyl Nuclear Power Plant Accident

2011 ◽  
Vol 11 ◽  
pp. S154
Author(s):  
N. Bilous ◽  
I. Abramenko ◽  
A. Chumak ◽  
Z. Martina ◽  
I. Dyagil ◽  
...  
Keyword(s):  
Power Plant ◽  
Chronic Lymphocytic Leukemia ◽  
Nuclear Power Plant ◽  
Ionizing Radiation ◽  
Nuclear Power ◽  
Chernobyl Nuclear Power Plant ◽  
Lymphocytic Leukemia ◽  
Gene Repertoire ◽  
Nuclear Power Plant Accident

scholarly journals THE DISTRIBUTION OF TP53 GENE POLYMORPHISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS, SUFFERERS OF CHORNOBYL NUCLEAR POWER PLANT ACCIDENT

2016 ◽  
Vol 38 (4) ◽  
pp. 252-256 ◽  
Author(s):  
N I Bilous ◽  
I V Abramenko ◽  
A A Chumak ◽  
I S Dyagil ◽  
Z V Martina
Keyword(s):  
Power Plant ◽  
Chronic Lymphocytic Leukemia ◽  
Nuclear Power Plant ◽  
Nuclear Power ◽  
Direct Sequencing ◽  
Main Group ◽  
Lymphocytic Leukemia ◽  
Control Group ◽  
Nuclear Power Plant Accident ◽  
Cleanup Workers

Previous analyses in a cohort of Chornobyl cleanup workers revealed significantly increased radiation-related risk for all leukemia types, including chronic lymphocytic leukemia (CLL). Numerous investigations emphasized the significance of genetic susceptibility to the radiation carcinogenesis. The aim of the work was to study the distribution of TP53 single nucleotide polymorphisms (SNPs) in CLL patients exposed to ionizing radiation (IR) due to Chornobyl nuclear power plant accident and estimate their impact on disease development. Materials and Methods: The TP53 exonic and intronic SNPs were analyzed in 236 CLL patients by polymerase chain reaction and direct sequencing. The main group included 106 IR exposed CLL patients and the control group was composed of 130 IR non-exposed CLL patients. Results: Nineteen TP53 SNPs were found in the observed CLL cohort. No significant differences were found between the main and the control groups, but increased frequencies of T/T rs12947788 + G/G rs12951053 homozygotes and rs146340390 C/T variants were found among IR-exposed CLL patients compared with healthy Europeans (data from the 1000 Genomes Project). Rare nucleotide substitution rs146340390 (c.665C>T) was found only in the main group. These features were primarily typical for the most affected group of IR-exposed patients, namely, cleanup workers engaged in emergency works in the 2nd quarter of 1986. Conclusion: These preliminary findings don’t contradict the assumption on possible influence of IR on CLL development via the p53-dependent pathway. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.

Behaviour of 137Cs from Chernobyl fallout in a Scots pine canopy in southern Finland

1994 ◽  
Vol 24 (6) ◽  
pp. 1210-1215 ◽  
Author(s):  
Pekka Nygren ◽  
Pertti Hari ◽  
Taisto Raunemaa ◽  
Markku Kulmala ◽  
Sinikka Luokkanen ◽  
...  
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Scots Pine ◽  
Half Life ◽  
Nuclear Power ◽  
Chernobyl Nuclear Power Plant ◽  
Lower Activity ◽  
Chernobyl Fallout ◽  
Nuclear Power Plant Accident ◽  
Time Of Year

The behaviour of 137Cs from the Chernobyl nuclear power plant accident in the Ukraine on 26 April 1986 was monitored during a 3-year period in the canopy of a young Scots pine (Pinussylvestris L.) stand in southern Finland. Needle samples were collected from the same whorls on 13 sample trees marked at the beginning of the study. The 137Cs activity of throughfall water was determined in summer 1986. The oldest needles at the time of the radioactive deposition (formed in 1983) had the highest l37Cs activity (20 000 Bq/kg) in June 1986, when the monitoring was started, 58 days after deposition. About 50% lower 137Cs activity was observed in the needles formed in 1984 and 1985, and an even lower activity of 3050 Bq/kg in the needles formed in 1986 following the incident. During the summer of 1986, the 137Cs activity of the whole canopy decreased from 106 000 to 42 500 kBq/ha, corresponding to a weathering half-life of 72 days. Washout by throughfall accounted for 79% of the decrease, while the rest was mainly due to the gradual shedding of the highly contaminated 1983 needles. The needles formed in the summers of 1987 and 1988 had rather high 137Cs activities of 2700 and 4800 Bq/kg, respectively. The reduction in the 137Cs activity of the canopy was considerably less in 1987 and 1988, with weathering half-lives of 435 and 242 days, respectively. The total 137Cs activity of the canopy was still 13 500 kBq/ha on 20 October 1988, which was 896 days after deposition. An increase in the 137Cs activity was observed in the autumns 1987 and 1988, and to a lesser degree in the autumn of 1986, a time of year when needle potassium concentrations normally tend to increase. It was concluded that the Chernobyl 137Cs had become mixed with the chemically analogous K, and was recirculated within the trees together with K.

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