Impact of Pretreatment Interstitial Lung Disease on Radiation Pneumonitis and Survival in Patients Treated With Lung Stereotactic Body Radiation Therapy (SBRT)

2018 ◽  
Vol 19 (2) ◽  
pp. e219-e226 ◽  
Author(s):  
Daniel Glick ◽  
Stephen Lyen ◽  
Sonja Kandel ◽  
Shane Shapera ◽  
Lisa W. Le ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Stereotactic Body Radiation Therapy ◽  
Radiation Pneumonitis ◽  
Stereotactic Body Radiation

scholarly journals Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade Sarcoma

Sarcoma ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Niraj Mehta ◽  
Michael Selch ◽  
Pin-Chieh Wang ◽  
Noah Federman ◽  
Jay M. Lee ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Stereotactic Body Radiation Therapy ◽  
Radiation Pneumonitis ◽  
High Grade ◽  
Term Survival ◽  
Stereotactic Body Radiation ◽  
High Grade Sarcoma ◽  
Radiation Esophagitis

Introduction. Patients with high-grade sarcoma (HGS) frequently develop metastatic disease thus limiting their long-term survival. Lung metastases (LM) have historically been treated with surgical resection (metastasectomy). A potential alternative for controlling LM could be stereotactic body radiation therapy (SBRT). We evaluated the outcomes from our institutional experience utilizing SBRT. Methods. Sixteen consecutive patients with LM from HGS were treated with SBRT between 2009 and 2011. Routine radiographic and clinical follow-up was performed. Local failure was defined as CT progression on 2 consecutive scans or growth after initial shrinkage. Radiation pneumonitis and radiation esophagitis were scored using Common Toxicity Criteria (CTC) version 3.0. Results. All 16 patients received chemotherapy, and a subset (38%) also underwent prior pulmonary metastasectomy. Median patient age was 56 (12–85), and median follow-up time was 20 months (range 3–43). A total of 25 lesions were treated and evaluable for this analysis. Most common histologies were leiomyosarcoma (28%), synovial sarcoma (20%), and osteosarcoma (16%). Median SBRT prescription dose was 54 Gy (36–54) in 3-4 fractions. At 43 months, local control was 94%. No patient experienced G2-4 radiation pneumonitis, and no patient experienced radiation esophagitis. Conclusions. Our retrospective experience suggests that SBRT for LM from HGS provides excellent local control and minimal toxicity.

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