scholarly journals Association of Cytoplasmic CXCR4 With Loss of Epithelial Marker and Activation of ERK1/2 and AKT Signaling Pathways in Non–Small-Cell Lung Cancer

2017 ◽  
Vol 18 (3) ◽  
pp. e203-e210 ◽  
Author(s):  
Nabil F. Saba ◽  
Yuxiang Wang ◽  
Hongpeng Fu ◽  
Lydia Koenig ◽  
Fadlo R. Khuri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Akt Signaling ◽  
Small Cell ◽  
Small Cell Lung ◽  
Epithelial Marker

scholarly journals Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiao-Zhong Liao ◽  
Ying Gao ◽  
Hong-Wei Zhao ◽  
Mi Zhou ◽  
Dan-Lei Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Akt Signaling ◽  
Small Cell ◽  
Akt Pathway ◽  
Small Cell Lung ◽  
Proliferation And Apoptosis

Cisplatin (DDP) is the first-line chemotherapeutic agent against lung cancer. However, the therapeutic effect of DDP loses over time due to the acquired drug resistance in non-small cell lung cancer (NSCLC) cells. In recent years, the role of the traditional Chinese medicine (TCM) cordycepin (Cor) in cancer treatment has been attracting attention. However, the effects of Cor on DDP resistance in NSCLC are unclear. In the present study, we aimed to investigate the effects of Cor in combination with DDP on cell proliferation and apoptosis in NSCLC and explore possible underlying mechanisms. The cell proliferation and apoptosis were analyzed in NSCLC parental (A549) and DDP-resistant (A549DDP) cells treated with DDP alone or in combination with Cor both in vitro and in vivo. Different genes and signaling pathways were investigated between DDP-sensitive and DDP-resistant A549 cells by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The perturbations of the MAPK and PI3K-AKT signaling pathways were evaluated by Western blot analysis. Our data showed that Cor markedly enhanced DDP inhibition on cell proliferation and promotion of apoptosis compared to the DDP-alone group in both A549 and A549DDP cells. The synergic actions were associated with activation of AMPK; inhibition of AKT, mTOR, and downstream P709S6K; and S6 phosphorylation in the AKT pathway compared with DDP alone. Collectively, combination of Cor and DDP has a synergistic effect in inhibiting proliferation and promoting apoptosis of NSCLC cells in the presence or absence of DDP resistance. The antitumor activity is associated with activation of AMPK and inhibition of the AKT pathway to enhance DDP inhibition on NSCLC. Our results suggested that Cor in combination with DDP could be an additional therapeutic option for the treatment of DDP-resistant NSCLC.

NUSAP1 knockdown inhibits cell growth and metastasis of non‐small‐cell lung cancer through regulating BTG2/PI3K/Akt signaling

2019 ◽  
Vol 235 (4) ◽  
pp. 3886-3893 ◽  
Author(s):  
ZheYuan Xu ◽  
Yang Wang ◽  
Jian Xiong ◽  
FengXian Cui ◽  
Lan Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Akt Signaling ◽  
Small Cell ◽  
Small Cell Lung

Autophagy-related signaling pathways in non-small cell lung cancer

2021 ◽  
Author(s):  
Jing Wang ◽  
Mei Gong ◽  
Xirong Fan ◽  
Dalu Huang ◽  
Jinshu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer

Tumor Biology ◽  
2011 ◽  
Vol 33 (2) ◽  
pp. 307-314 ◽  
Author(s):  
Yuanzi Yu ◽  
Dongtao Yin ◽  
Mohammad O. Hoque ◽  
Baoping Cao ◽  
Yan Jia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathway ◽  
Cell Lung Cancer ◽  
Akt Signaling ◽  
Small Cell ◽  
Akt Signaling Pathway ◽  
Small Cell Lung
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