BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment

2019 ◽  
Vol 201 ◽  
pp. 4-14 ◽  
Author(s):  
Kangkang Liu ◽  
Erlin Sun ◽  
Mingde Lei ◽  
Limin Li ◽  
Jingda Gao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Treatment ◽  
Neutrophil Extracellular Traps ◽  
Extracellular Traps

scholarly journals Role of MicroRNAs in BCG Therapy by the Induction of Neutrophil Extracellular Traps in Bladder Cancer

2020 ◽  
pp. 17-28
Author(s):  
Mohammad Mehdi Adibzadeh Sereshgi ◽  
Ali Mohammad Mohseni Majd ◽  
Sahar Salimi ◽  
Hassan Noorbazargan
Keyword(s):  
Bladder Cancer ◽  
Neutrophil Extracellular Traps ◽  
Extracellular Traps ◽  
Bcg Therapy

scholarly journals Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Surashri Shinde-Jadhav ◽  
Jose Joao Mansure ◽  
Roni F. Rayes ◽  
Gautier Marcq ◽  
Mina Ayoub ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Neutrophil Extracellular Traps ◽  
Polymorphonuclear Neutrophils ◽  
Dependent Manner ◽  
Potential Therapeutic Target ◽  
Extracellular Traps ◽  
Tumor Immune Microenvironment

AbstractRadiation therapy (RT) is used in the management of several cancers; however, tumor radioresistance remains a challenge. Polymorphonuclear neutrophils (PMNs) are recruited to the tumor immune microenvironment (TIME) post-RT and can facilitate tumor progression by forming neutrophil extracellular traps (NETs). Here, we demonstrate a role for NETs as players in tumor radioresistance. Using a syngeneic bladder cancer model, increased NET deposition is observed in the TIME of mice treated with RT and inhibition of NETs improves overall radiation response. In vitro, the protein HMGB1 promotes NET formation through a TLR4-dependent manner and in vivo, inhibition of both HMGB1 and NETs significantly delays tumor growth. Finally, NETs are observed in bladder tumors of patients who did not respond to RT and had persistent disease post-RT, wherein a high tumoral PMN-to-CD8 ratio is associated with worse overall survival. Together, these findings identify NETs as a potential therapeutic target to increase radiation efficacy.

scholarly journals Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine

2021 ◽  
Vol 8 ◽  
Author(s):  
Chenyu Mao ◽  
Xin Xu ◽  
Yongfeng Ding ◽  
Nong Xu
Keyword(s):  
Bladder Cancer ◽  
Tumor Cells ◽  
Metastatic Cancer ◽  
Tumor Development ◽  
Neutrophil Extracellular Traps ◽  
Extracellular Traps ◽  
Bcg Therapy ◽  
Activated Neutrophils ◽  
Apoptosis Pathways ◽  
Important Regulator

Bladder cancer (BC) is the ninth most common cancer and the thirteenth most common cause of mortality worldwide. Bacillus Calmette Guerin (BCG) instillation is a common treatment option for BC. BCG therapy is associated with the less adversary effects, compared to chemotherapy, radiotherapy, and other conventional treatments. BCG could inhibit the progression and recurrence of BC by triggering apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formation. However, BCG therapy is not efficient for metastatic cancer. NETs and autophagy were induced by BCG and help to suppress the growth of tumor cells especially in the primary stages of BC. Activated neutrophils can stimulate autophagy pathway and release NETs in the presence of microbial pathogenesis, inflammatory agents, and tumor cells. Autophagy can also regulate NETs formation and induce production of reactive oxygen species (ROS) and NETs. Moreover, miRNAs are important regulator of gene expression. These small non-coding RNAs are also considered as an essential factor to control the levels of tumor development. However, the interaction between BCG and miRNAs has not been well-understood yet. Therefore, the present study discusses the roles of miRNAs in regulations of autophagy and NETs formation in BCG therapy in the treatment of BC. The roles of autophagy and NETs formation in BC treatment and efficiency of BCG are also discussed.

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