Positive selection of type II collagen-reactive CD80 high marginal zone B cells in DBA/1 mice

2017 ◽  
Vol 178 ◽  
pp. 64-73 ◽  
Author(s):  
Chanho Park ◽  
In Seong Kho ◽  
Jeong In Yang ◽  
Min-Jung Kim ◽  
Sunhoo Park ◽  
...  
Keyword(s):  
B Cells ◽  
Positive Selection ◽  
Marginal Zone ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Marginal Zone B Cells ◽  
Selection Of

scholarly journals The Selection of Marginal Zone B Cells Differs from That of B-1a Cells

2003 ◽  
Vol 171 (12) ◽  
pp. 6495-6501 ◽  
Author(s):  
Karsten Kretschmer ◽  
Anke Jungebloud ◽  
Jana Stopkowicz ◽  
Tanja Kleinke ◽  
Reinhard Hoffmann ◽  
...  
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Selection Of

scholarly journals Selection of stereotyped VH81X-μH chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells

2005 ◽  
Vol 17 (7) ◽  
pp. 857-867 ◽  
Author(s):  
Yohei Kawano ◽  
Soichiro Yoshikawa ◽  
Yoshiyuki Minegishi ◽  
Hajime Karasuyama
Keyword(s):  
B Cells ◽  
B Cell ◽  
Marginal Zone ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Marginal Zone B Cells ◽  
Selection Of

scholarly journals Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Yang Yang ◽  
Chunlin Wang ◽  
Qunying Yang ◽  
Aaron B Kantor ◽  
Hiutung Chu ◽  
...  
Keyword(s):  
B Cells ◽  
Large Scale ◽  
Marginal Zone ◽  
De Novo ◽  
Cell Lineage ◽  
Marginal Zone B Cells ◽  
Igh Rearrangement ◽  
Facs Sorting ◽  
Selection Of

Processes that define immunoglobulin repertoires are commonly presumed to be the same for all murine B cells. However, studies here that couple high-dimensional FACS sorting with large-scale quantitative IgH deep-sequencing demonstrate that B-1a IgH repertoire differs dramatically from the follicular and marginal zone B cells repertoires and is defined by distinct mechanisms. We track B-1a cells from their early appearance in neonatal spleen to their long-term residence in adult peritoneum and spleen. We show that de novo B-1a IgH rearrangement mainly occurs during the first few weeks of life, after which their repertoire continues to evolve profoundly, including convergent selection of certain V(D)J rearrangements encoding specific CDR3 peptides in all adults and progressive introduction of hypermutation and class-switching as animals age. This V(D)J selection and AID-mediated diversification operate comparably in germ-free and conventional mice, indicating these unique B-1a repertoire-defining mechanisms are driven by antigens that are not derived from microbiota.

Development and selection of marginal zone B cells

2004 ◽  
Vol 197 (1) ◽  
pp. 192-205 ◽  
Author(s):  
Thiago Lopes-Carvalho ◽  
John F. Kearney
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Selection Of
Sign in / Sign up

Export Citation Format

Share Document