Toll-like receptor 4-induced cytokine production circumvents protection conferred by TGF-β in coxsackievirus-mediated autoimmune myocarditis

2006 ◽  
Vol 121 (3) ◽  
pp. 339-349 ◽  
Author(s):  
Martin J. Richer ◽  
Dianne Fang ◽  
Iryna Shanina ◽  
Marc S. Horwitz
Keyword(s):  
Cytokine Production ◽  
Toll Like Receptor ◽  
Autoimmune Myocarditis ◽  
Toll Like Receptor 4

scholarly journals Bacteroides fragilis-Derived Lipopolysaccharide Produces Cell Activation and Lethal Toxicity via Toll-Like Receptor 4

2005 ◽  
Vol 73 (9) ◽  
pp. 5620-5627 ◽  
Author(s):  
Giuseppe Mancuso ◽  
Angelina Midiri ◽  
Carmelo Biondo ◽  
Concetta Beninati ◽  
Maria Gambuzza ◽  
...  
Keyword(s):  
Cell Activation ◽  
Cytokine Production ◽  
Biological Activities ◽  
Endotoxic Shock ◽  
Intestinal Flora ◽  
Bacteroides Fragilis ◽  
Peritoneal Macrophages ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
In Cells

ABSTRACT Bacteroides fragilis, which is part of the normal intestinal flora, is a frequent cause of serious disease, especially in diabetic and surgical patients. In these conditions, B. fragilis lipopolysaccharide (LPS) is likely to play a major pathophysiologic role. B. fragilis LPS is structurally different from classical enterobacterial LPS, whose biological activities are mediated by Toll-like receptor 4 (TLR4) activation. The ability of B. fragilis LPS to activate TLR4 and TLR2 was investigated here, since evidence on this issue is scarce and controversial. Each of four different protein-free B. fragilis LPS preparations could induce interleukin-8 responses in cells cotransfected with TLR4/CD14/MD2 but not TLR4/CD14 alone. Two of the preparations also induced cytokine production in cells cotransfected with TLR2/CD14 or in peritoneal macrophages from TLR4 mutant C3H/HeJ mice. Both of these activities, however, were lost after repurification with a modified phenol reextraction procedure. Importantly, all preparations could induce endotoxic shock in TLR2-deficient mice, but not in TLR4 mutant C3H/HeJ mice. Consistent with these findings, anti-TLR4 and anti-CD14, but not anti-TLR2, antibodies could inhibit B. fragilis LPS-induced cytokine production in human monocytes. Collectively, these results indicate that B. fragilis LPS signals via a TLR4/CD14/MD2-dependent pathway, and it is unable to activate TLR2. Moreover, our data document the occurrence of TLR2-activating contaminants even in highly purified B. fragilis LPS preparations. This may explain earlier contradictory findings on the ability of B. fragilis LPS to activate cells in the absence of functional TLR4. These data may be useful to devise strategies to prevent the pathophysiologic changes observed during B. fragilis sepsis and to better understand structure-activity relationships of LPS.

Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages

2002 ◽  
Vol 2 (8) ◽  
pp. 1155-1162 ◽  
Author(s):  
Izuru Ando ◽  
Yoshinori Tsukumo ◽  
Tetsuya Wakabayashi ◽  
Sachiko Akashi ◽  
Kensuke Miyake ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cytokine Production ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

OR.44. Toll-like Receptor 4 Engagement Blocks Inflammatory Cytokine Production by B Cells from Inflammatory Disease Patients

2009 ◽  
Vol 131 ◽  
pp. S21
Author(s):  
Madhumita Jagannathan ◽  
Hyunjin Shin ◽  
Yue Zhang ◽  
Hatice Hasturk ◽  
Alpdogan Kantarci ◽  
...  
Keyword(s):  
B Cells ◽  
Inflammatory Disease ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Cytokine Production

scholarly journals Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

2014 ◽  
Vol 44 (5) ◽  
pp. 1480-1490 ◽  
Author(s):  
Chien-Hsiung Yu ◽  
Tam T. K. Nguyen ◽  
Katharine M. Irvine ◽  
Matthew J. Sweet ◽  
Ian H. Frazer ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Macrophage Cytokine

TAK-242 SUPPRESSES TOLL-LIKE RECEPTOR 4-MEDIATED CYTOKINE PRODUCTION AND PROTECTS MICE FROM ESCHERICHIA COLI-INDUCED LETHALITY

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A15
Author(s):  
Masayuki Ii ◽  
Mie Sunamoto ◽  
Naoko Matsunaga ◽  
Kazuyo Nakamura ◽  
Katsunori Takashima ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Cytokine Production ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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