Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma

2006 ◽  
Vol 121 (3) ◽  
pp. 358-368 ◽  
Author(s):  
Karin Enarsson ◽  
Anna Lundgren ◽  
Bert Kindlund ◽  
Mikael Hermansson ◽  
Giovanna Roncador ◽  
...  
Keyword(s):  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells ◽  
Gastric Adenocarcinoma ◽  
Helicobacter Pylori Infection

scholarly journals Mucosal FOXP3-Expressing CD4+ CD25high Regulatory T Cells in Helicobacter pylori-Infected Patients

2005 ◽  
Vol 73 (1) ◽  
pp. 523-531 ◽  
Author(s):  
Anna Lundgren ◽  
Erika Strömberg ◽  
Åsa Sjöling ◽  
Catharina Lindholm ◽  
Karin Enarsson ◽  
...  
Keyword(s):  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells ◽  
Gastric Adenocarcinoma ◽  
Cytotoxic T Lymphocyte ◽  
Duodenal Mucosa ◽  
Peptic Ulcers ◽  
Low Levels ◽  
H Pylori ◽  
And Function

ABSTRACT Helicobacter pylori chronically colonizes the stomach and duodenum and causes peptic ulcers or gastric adenocarcinoma in 10 to 20% of infected individuals. We hypothesize that the inability of patients to clear H. pylori infections is a consequence of active suppression of the immune response. Here we show that H. pylori-infected individuals have increased frequencies of CD4+ CD25high T cells in both the stomach and duodenal mucosa compared to uninfected controls. These cells have the phenotype of regulatory T cells, as they express FOXP3, a key gene for the development and function of regulatory T cells, as well as high levels of the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) protein. In contrast, mucosal CD4+ CD25low and CD4+ CD25− cells express little FOXP3 mRNA and low levels of the CTLA-4 protein. Mucosal CD4+ CD25high T cells are present in individuals with asymptomatic H. pylori infections as well as in duodenal ulcer patients. The frequencies of CD4+ CD25high cells are also increased in the stomachs of H. pylori-infected patients with gastric adenocarcinoma, particularly in cancer-affected tissues. These findings suggest that regulatory T cells may suppress mucosal immune responses and thereby contribute to the persistence of H. pylori infections.

scholarly journals Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells

2011 ◽  
Vol 121 (8) ◽  
pp. 3088-3093 ◽  
Author(s):  
Isabelle C. Arnold ◽  
Nina Dehzad ◽  
Sebastian Reuter ◽  
Helen Martin ◽  
Burkhard Becher ◽  
...  
Keyword(s):  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells ◽  
Allergic Asthma ◽  
Mouse Models ◽  
Helicobacter Pylori Infection

Role of Regulatory T-cells in Different Clinical Expressions of Helicobacter pylori Infection

2016 ◽  
Vol 47 (4) ◽  
pp. 245-254 ◽  
Author(s):  
Nader Bagheri ◽  
Fatemeh Azadegan-Dehkordi ◽  
Ghorbanali Rahimian ◽  
Mahmoud Rafieian-Kopaei ◽  
Hedayatollah Shirzad
Keyword(s):  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells ◽  
Helicobacter Pylori Infection
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