OR.103. Immature Human Dendritic Cells Express Latency-Associated Peptide (LAP) and Inhibit T-Cell Activation in a Tgf-β Dependent Fashion

2006 ◽  
Vol 119 ◽  
pp. S43
Author(s):  
Roopali Gandhi ◽  
David Anderson ◽  
Howard Weiner
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Dendritic Cells

scholarly journals Both Maturation and Survival of Human Dendritic Cells are Impaired in the Presence of Anergic/Suppressor T Cells

2003 ◽  
Vol 10 (1) ◽  
pp. 61-65 ◽  
Author(s):  
L. Frasca ◽  
C. Scottà ◽  
G. Lombardi ◽  
E. Piccolella
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Costimulatory Molecule ◽  
T Cell Suppression ◽  
Cell Suppression ◽  
Anergic T Cells ◽  
Human Dendritic Cells

T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter of debate. Mouse anergic T cells were shown to suppress responder T cell activation by inhibiting the antigen presenting function of DC. In the present work we studied the effects of co-culturing human anergic CD4+T cells with autologous dendritic cells (DC) at different stages of maturation. Either DC maturation or survival, depending on whether immature or mature DC where used as APC, was impaired in the presence of anergic cells. Indeed, MHC and costimulatory molecule up-regulation was inhibited in immature DC, whereas apoptotic phenomena were favored in mature DC and consequently in responder T cells. Defective ligation of CD40 by CD40L (CD154) was responsible for CD95-mediated and spontaneous apoptosis of DC as well as for a failure of their maturation process. These findings indicate that lack of activation of CD40 on DC by CD40L-defective anergic cells might be the primary event involved in T cell suppression and support the role of CD40 signaling in regulating both activation and survival of DC.

scholarly journals Triggering of TLR-3, -4, NOD2, and DC-SIGN reduces viral replication and increases T-cell activation capacity of HIV-infected human dendritic cells

2017 ◽  
Vol 47 (5) ◽  
pp. 818-829 ◽  
Author(s):  
Sylvain Cardinaud ◽  
Alejandra Urrutia ◽  
Angeline Rouers ◽  
Pierre-Grégoire Coulon ◽  
Jérome Kervevan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Viral Replication ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Dendritic Cells ◽  
Activation Capacity

scholarly journals Correction: The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation

2011 ◽  
Vol 187 (12) ◽  
pp. 6584-6584
Author(s):  
Daniela Ortner ◽  
Daniela Grabher ◽  
Martin Hermann ◽  
Elisabeth Kremmer ◽  
Susanne Hofer ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Mhc Class I ◽  
T Cell Activation ◽  
Cell Activation ◽  
Adaptor Protein ◽  
Cd8 T Cell ◽  
Class I ◽  
Human Dendritic Cells

scholarly journals Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation

Gene Therapy ◽  
1998 ◽  
Vol 5 (2) ◽  
pp. 264-271 ◽  
Author(s):  
J Westermann ◽  
A Aicher ◽  
Z Qin ◽  
S Cayeux ◽  
K Daemen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Gene Transfer ◽  
T Cell Activation ◽  
Cell Activation ◽  
Interleukin 7 ◽  
Human Dendritic Cells

scholarly journals Human Metapneumovirus SH and G Glycoproteins Inhibit Macropinocytosis-Mediated Entry into Human Dendritic Cells and Reduce CD4+ T Cell Activation

2014 ◽  
Vol 88 (11) ◽  
pp. 6453-6469 ◽  
Author(s):  
C. Le Nouen ◽  
P. Hillyer ◽  
L. G. Brock ◽  
C. C. Winter ◽  
R. L. Rabin ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Metapneumovirus ◽  
Cd4 T Cell ◽  
Human Dendritic Cells

scholarly journals The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation

2011 ◽  
Vol 187 (8) ◽  
pp. 3972-3978 ◽  
Author(s):  
Daniela Ortner ◽  
Daniela Grabher ◽  
Martin Hermann ◽  
Elisabeth Kremmer ◽  
Susanne Hofer ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Mhc Class I ◽  
T Cell Activation ◽  
Cell Activation ◽  
Adaptor Protein ◽  
Cd8 T Cell ◽  
Class I ◽  
Human Dendritic Cells

scholarly journals Morphine Reciprocally Regulates IL-10 and IL-12 Production by Monocyte-Derived Human Dendritic Cells and Enhances T Cell Activation

2006 ◽  
Vol 12 (11-12) ◽  
pp. 284-290 ◽  
Author(s):  
Davorka Messmer ◽  
Ikusuke Hatsukari ◽  
Naoko Hitosugi ◽  
Ingo G H Schmidt-Wolf ◽  
Pravin C Singhal
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Dendritic Cells
Sign in / Sign up

Export Citation Format

Share Document