Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls

2005 ◽  
Vol 115 (1) ◽  
pp. 102-114 ◽  
Author(s):  
P OTT ◽  
B HERZOG ◽  
S QUAST ◽  
H HOFSTETTER ◽  
B BOEHM ◽  
...  
Keyword(s):  
T Cells ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Cell Antigen ◽  
Type 1 Diabetic Patients ◽  
Th2 Differentiation

scholarly journals Antibodies Recognizing Mycobacterium avium paratuberculosis Epitopes Cross-React with the Beta-Cell Antigen ZnT8 in Sardinian Type 1 Diabetic Patients

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26931 ◽  
Author(s):  
Speranza Masala ◽  
Daniela Paccagnini ◽  
Davide Cossu ◽  
Vedran Brezar ◽  
Adolfo Pacifico ◽  
...  
Keyword(s):  
Beta Cell ◽  
Mycobacterium Avium ◽  
Diabetic Patients ◽  
Mycobacterium Avium Paratuberculosis ◽  
Cell Antigen ◽  
Type 1 Diabetic Patients

scholarly journals Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

Diabetes ◽  
2009 ◽  
Vol 58 (10) ◽  
pp. 2267-2276 ◽  
Author(s):  
R. Hilbrands ◽  
V. A.L. Huurman ◽  
P. Gillard ◽  
J. H.L. Velthuis ◽  
M. De Waele ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Islet Cell Transplantation ◽  
Type 1 Diabetic Patients

scholarly journals Serum IL-17, IL-23, and TGF-βLevels in Type 1 and Type 2 Diabetic Patients and Age-Matched Healthy Controls

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Azam Roohi ◽  
Mina Tabrizi ◽  
Farzaneh Abbasi ◽  
Asal Ataie-Jafari ◽  
Behrouz Nikbin ◽  
...  
Keyword(s):  
Serum Levels ◽  
Diabetic Patients ◽  
Low Grade ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Type 1 Diabetic Patients ◽  
Type 2 Diabetic

Type 1 diabetes is recognized as an autoimmune inflammatory disease and low grade inflammation is also observed in type 2 diabetic patients. Interleukin 17 (IL-17) is a new player in inflammation. Th17 cells, as the main source of IL-17, require transforming growth factorβ(TGF-β) and interleukin 23 (IL-23). The aim of this study was to investigate serum IL-17, IL-23 and TGF-βlevels in diabetic patients and controls. In this case-control study, serum levels of IL-17, IL-23, and TGF-βwere measured in 24 type 1 diabetic patients and 30 healthy controls using the ELISA method. Simultaneously, the same methodology was used to compare serum concentration of these three cytokines in 38 type 2 diabetic patients and 40 healthy controls. There was no significant difference between serum levels of IL-17 and IL-23 cytokines between cases and controls. However, TGF-βwas significantly lower in type 1 diabetic patients (P<0.001). Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-βlevels were lower in type 1 diabetic patients.

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