Clinical Development of Immunotherapy for Deficient Mismatch Repair Colorectal Cancer

2020 ◽  
Vol 19 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Jane Thomas ◽  
Alexis Leal ◽  
Michael J. Overman
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Clinical Development ◽  
Deficient Mismatch Repair

Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in colorectal cancer: a meta-analysis

2022 ◽  
Author(s):  
Chunhui Jin ◽  
Xiaodan Zhu ◽  
Xiaona Huang ◽  
Tingjie Gong ◽  
Zhipeng Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Mismatch Repair ◽  
Checkpoint Inhibitors ◽  
Meta Analysis ◽  
Objective Response ◽  
Progression Free Survival ◽  
Adverse Event Rate ◽  
Efficacy And Safety ◽  
Deficient Mismatch Repair

Aims: To evaluate the efficacy and safety of PD-1/PD-L1 and/or CTLA-4 inhibitors in the treatment of colorectal cancer (CRC) by meta-analysis. Methods: Electronic databases were searched. Eligible studies included investigations of efficacy and safety of anti-PD-1/PD-L1 or anti-CTLA-4 agents in patients with CRC. Corresponding indicators were calculated. Results: A total of 15 articles were included. The pooled objective response rate, overall survival rate, progression-free survival rate and adverse event rate were 33, 56, 46 and 59%, respectively. The objective response rates for CRC with deficient mismatch repair and CRC with proficient mismatch repair were 43 and 3%, respectively, in patients treated with PD-1 inhibitors. Conclusion: The authors' study indicates that PD-1/PD-L1 inhibitors manifest promising clinical responses in the treatment of CRC with deficient mismatch repair with acceptable treatment-related adverse events.

scholarly journals Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer

2016 ◽  
Vol 13 (9) ◽  
pp. 892 ◽  
Author(s):  
Cong-Min Zhang ◽  
Jin-Feng Lv ◽  
Liang Gong ◽  
Lin-Yu Yu ◽  
Xiao-Ping Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Personalized Management ◽  
Deficient Mismatch Repair

Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients

2013 ◽  
Vol 45 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Thomas Aparicio ◽  
Olivier Schischmanoff ◽  
Cecile Poupardin ◽  
Nadem Soufir ◽  
Celine Angelakov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Elderly Patients ◽  
Mismatch Repair ◽  
Deficient Mismatch Repair
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