Sodium Glucose Cotransporter 2 Inhibition Combined With Cetuximab Significantly Reduced Tumor Size and Carcinoembryonic Antigen Level in Colon Cancer Metastatic to Liver

2018 ◽  
Vol 17 (1) ◽  
pp. e45-e48 ◽  
Author(s):  
Junichi Okada ◽  
Shunichi Matsumoto ◽  
Kyoichi Kaira ◽  
Tsugumichi Saito ◽  
Eijiro Yamada ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Carcinoembryonic Antigen ◽  
Tumor Size ◽  
Antigen Level ◽  
Sodium Glucose Cotransporter

The predictive value of preoperative carcinoembryonic antigen level in the prognosis of colon cancer

2012 ◽  
Vol 204 (4) ◽  
pp. 447-452 ◽  
Author(s):  
Hasan T. Kirat ◽  
Ersin Ozturk ◽  
Ian C. Lavery ◽  
Ravi P. Kiran
Keyword(s):  
Colon Cancer ◽  
Carcinoembryonic Antigen ◽  
Predictive Value ◽  
Antigen Level

Concurrent measurements of carcinoembryonic antigen, glucosephosphate isomerase, gamma-glutamyltransferase, and lactate dehydrogenase in malignant, normal adult, and fetal colon tissues.

1980 ◽  
Vol 26 (13) ◽  
pp. 1809-1812 ◽  
Author(s):  
D D Munjal
Keyword(s):  
Colon Cancer ◽  
Lactate Dehydrogenase ◽  
Carcinoembryonic Antigen ◽  
Tumor Tissue ◽  
Human Colon ◽  
Normal Adult ◽  
Metastatic Colon Cancer ◽  
Glucosephosphate Isomerase ◽  
Adult Human ◽  
Fetal Organs

Abstract Carcinoembryonic antigen and activities of glucosephosphate isomerase (EC 5.3.1.9), γ-glutamyltransferase (EC 2.3.2.2), and lactate dehydrogenase (EC 1.1.1.27) were measured in aqueous extracts of fetal, normal adult, and malignant human colon tissues. Fetal colon, as well as primary and metastatic colon tumor tissue, showed higher activities of these analytes than did normal adult human colon. Liver metastases of colon cancer gave the highest values, normal adult human colon the lowest. Statistically, these differences were more striking in the case of carcinoembryonic antigen and glucosephosphate isomerase than for γ-glutamyltransferase or lactate dehydrogenase. In contrast to the other markers, γ-glutamyltransferase activity was lower in fetal organs than in normal adult colon and colon tumors. These results are consistent with earlier observations that activities of these markers are significantly increased in the blood of patients with metastatic colon cancer.

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