Assessing the Effect of Lifetime Contralateral Breast Cancer Risk on the Selection of Contralateral Prophylactic Mastectomy for Unilateral Breast Cancer

2018 ◽  
Vol 18 (2) ◽  
pp. e205-e218 ◽  
Author(s):  
John V. Hegde ◽  
Xiaoyan Wang ◽  
Deanna J. Attai ◽  
Maggie L. DiNome ◽  
Amy Kusske ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Contralateral Breast Cancer ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Contralateral Breast ◽  
Unilateral Breast Cancer ◽  
Selection Of

scholarly journals Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 140 ◽  
Author(s):  
Victoria Teoh ◽  
Marios-Konstantinos Tasoulis ◽  
Gerald Gui
Keyword(s):  
Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Risk Groups ◽  
Genetic Mutation ◽  
Contralateral Breast ◽  
Strong Family History ◽  
Unilateral Breast Cancer

The uptake of contralateral prophylactic mastectomy is rising with increasing trends that are possibly highest in the USA. Whilst its role is generally accepted in carriers of recognized high-risk predisposition genes such as BRCA1 and BRCA2 when the affected individual is premenopausal, controversy surrounds the benefit in less understood risk-profile clinical scenarios. This comprehensive review explores the current evidence underpinning the role of contralateral prophylactic mastectomy and its impact on contralateral breast cancer risk and survival in three distinct at-risk groups affected by unilateral breast cancer: known genetic carriers, those with strong familial risk but no demonstrable genetic mutation and women who are of young age at presentation. The review supports the role of contralateral prophylactic mastectomy in “high risk” groups where the evidence suggests a reduction in contralateral breast cancer risk. However, this benefit is less evident in women who are just young at presentation or those who have strong family history but no demonstrable genetic mutation. A multidisciplinary and personalized approach to support individuals in a shared-decision making process is recommended.

scholarly journals Predictors of contralateral breast cancer in patients with unilateral breast cancer undergoing contralateral prophylactic mastectomy

Cancer ◽  
2009 ◽  
Vol 115 (5) ◽  
pp. 962-971 ◽  
Author(s):  
Min Yi ◽  
Funda Meric-Bernstam ◽  
Lavinia P. Middleton ◽  
Banu K. Arun ◽  
Isabelle Bedrosian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Contralateral Breast ◽  
Unilateral Breast Cancer

scholarly journals Contralateral breast cancer risk in relation to tumor morphology and age—in which patients is preoperative MRI justified?

2015 ◽  
Vol 150 (1) ◽  
pp. 191-198 ◽  
Author(s):  
N. A. de Glas ◽  
C. C. Engels ◽  
E. Bastiaannet ◽  
W. van de Water ◽  
S. Siesling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Tumor Morphology

Abstract PD6-5: The association between radiotherapy and contralateral breast cancer risk in youngBRCA1/2-associated breast cancer patients

2020 ◽  
Author(s):  
Mark van Barele ◽  
Delal Akdeniz ◽  
Bernadette AM Heemskerk-Gerritsen ◽  
Margreet HA Baaijens ◽  
Margriet GA Sattler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Breast Cancer Patients
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