Imatinib Alleviated Pulmonary Hypertension Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Metastatic Breast Cancer

2015 ◽  
Vol 15 (2) ◽  
pp. e167-e170 ◽  
Author(s):  
Ippei Fukada ◽  
Kazuhiro Araki ◽  
Shun Minatsuki ◽  
Takeo Fujino ◽  
Masaru Hatano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Hypertension ◽  
Metastatic Breast Cancer ◽  
Thrombotic Microangiopathy ◽  
Metastatic Breast ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

scholarly journals A Case of Recurrent Breast Cancer Identified by Pulmonary Tumor Thrombotic Microangiopathy

2017 ◽  
Vol 10 (2) ◽  
pp. 620-626 ◽  
Author(s):  
Tomomi Abe ◽  
Ippei Fukada ◽  
Taro Shiga ◽  
Hidetomo Morizono ◽  
Koichi  Ikebata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Performance Status ◽  
Recurrent Breast Cancer ◽  
Left Breast ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy ◽  
Recurrent Breast ◽  
Perfusion Lung Scintigraphy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare, cancer-related, pulmonary complication that causes hypoxia and pulmonary hypertension. We report on a 42-year-old woman who was diagnosed with recurrent breast cancer that was detected due to the presence of PTTM. Eleven months after surgery for heterochronous bilateral cancer of the left breast, she developed progressive dyspnea but computerized tomography showed no pulmonary thromboembolism, and a transthoracic echocardiography revealed mild pulmonary hypertension. She was diagnosed with PTTM by cytology from pulmonary artery catheterization and perfusion lung scintigraphy. Also, the patients complained of back pain after admission, bone scintigraphy showed multiple bone metastases. Despite the early diagnosis of PTTM, her platelet count decreased, her performance status rapidly deteriorated, and her dyspnea worsened. Thus, we could not treat her with chemotherapy. She died due to respiratory failure 19 days after admission. To the best of our knowledge, this is the first report of recurrent breast cancer identified by the manifestation of PTTM. Although PTTM is a rare phenomenon, it should be considered in the differential diagnosis of acute dyspnea or pulmonary hypertension in patients with breast cancer. Furthermore, upon diagnosis, the patient should be referred to a cardiologist as soon as possible.

scholarly journals Pulmonary Tumor Thrombotic Microangiopathy as a Cause of Pulmonary Hypertension

2021 ◽  
Vol 3 (7) ◽  
pp. 1029-1031
Author(s):  
Benjamin P. Schwartz ◽  
Philip Tracy ◽  
Stephanie Hon ◽  
Harrison W. Farber ◽  
James E. Udelson
Keyword(s):  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

scholarly journals Pulmonary Hypertension Caused by Lung Cancer Suspected to Have Pulmonary Tumor Thrombotic Microangiopathy and Which We Treated with Gefitinib

Haigan ◽  
2012 ◽  
Vol 52 (4) ◽  
pp. 420-425 ◽  
Author(s):  
Kiyokazu Yoshinoya ◽  
Yu Kasamatsu ◽  
Shougen Boku ◽  
Takashi Kida ◽  
Masatoshi Kadoya ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

scholarly journals Pulmonary tumor thrombotic microangiopathy presenting as recurrent syncope

2020 ◽  
Vol 8 ◽  
pp. 2050313X2096904
Author(s):  
Constanza Burciaga Calderoni ◽  
Dafne T Moretta ◽  
Jeanette Merrill-Henry ◽  
Paresh C Giri
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Rare Condition ◽  
Right Heart Failure ◽  
Coagulation Cascade ◽  
Right Heart ◽  
Rare Presentation ◽  
Pulmonary Tumor ◽  
Pulmonary Tumor Thrombotic Microangiopathy

Pulmonary tumor thrombotic microangiopathy is a rare condition in which embolization of tumor cells to the pulmonary arterioles causes fibrocellular intimal thickening and activation of the coagulation cascade resulting in pulmonary hypertension and right heart failure. Herein, we highlight a young 35-year-old male with no known past medical history who presented with recurrent syncope and dyspnea, and was found to have severe right heart failure and pulmonary hypertension. He developed sudden clinical deterioration and died after a cardiac arrest. Autopsy revealed poorly differentiated gastric adenocarcinoma and pulmonary tumor thrombotic microangiopathy. New onset severe pulmonary hypertension and right heart failure without any other obvious etiology should encourage the reader to evaluate for pulmonary tumor thrombotic microangiopathy and undergo a diligent search for underlying malignancy. This case highlights recurrent syncope as a rare presentation of this rapidly fatal disease.

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