The Effectiveness of CS Reducer for the treatment of Refractory Angina – a Meta-Analysis

2021 ◽  
Author(s):  
Aviram Hochstadt ◽  
Tamar Itach ◽  
Ilan Merdler ◽  
Eihab Ghantous ◽  
Tomer Ziv-Baran ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Refractory Angina

scholarly journals AN UPDATED COMPREHENSIVE META-ANALYSIS OF RANDOMIZED TRIALS EVALUATING THE EFFICACY OF STEM CELL THERAPY FOR REFRACTORY ANGINA

2017 ◽  
Vol 69 (11) ◽  
pp. 15
Author(s):  
Muhammad Shahreyar ◽  
Mohamed Morsy ◽  
Mark Heckle ◽  
Abdul Rashid ◽  
Kodangudi Ramanathan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Refractory Angina

scholarly journals Safety and effectiveness of Enhanced External Counterpulsation (EECP) in Refractory Angina Patients: Systematic Reviews and Meta-Analysis

2021 ◽  
Author(s):  
Seyed Mansoor Rayegani ◽  
Saeed Heidari ◽  
Majid Maleki ◽  
Maryam Seyed-Nezhad ◽  
Maryam Heidari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Walking Distance ◽  
Cochrane Library ◽  
Refractory Angina ◽  
Exclusion Criteria ◽  
External Counterpulsation ◽  
Significant Difference ◽  
Enhanced External Counterpulsation

Enhanced external counterpulsation (EECP) is believed to be a non-invasive treatment for coronary artery disease and angina. The aim of this study was to determine the safety and effectiveness of EECP in refractory angina patients through a systematic reviews and meta-analysis. We conducted a comprehensive search of the literature published on PubMed, Cochrane library, Scopus, ScienceDirect, Trip Database and Google Scholar databases using appropriate keywords and specific strategy with no time limit. Having selected and screened the studies based on the defined inclusion and exclusion criteria and evaluating their quality based on the Cochrane checklist. For the meta-analysis,the Mantel-Haenszel method or the generic Inverse Variance was used. Analyses were done with Review Manager 5.2 software. A number of 299 studies were initially reviewed and finally, seventeen studies were included in the meta-analysis based on the inclusion and exclusion criteria. Also, thirteen outcomes were analyzed and the results of meta-analysis in twelve outcomes including (Systolic Blood Pressure (7 studies), Diastolic Blood Pressure (7 studies), Pulse Pressure (4 studies), Mean Arterial Pressures (4 studies), Heart Rate (6 studies), Angina episodes (7 studies), Walking distance (2 studies),Canadian Cardiovascular Society classification (6 studies), Flow-Mediated Dilation (3 studies), Daily Nitrate Usage (4 studies), Exercise Treadmill Test-Time (2 studies), ST-segment depression (2 studies)demonstrated a significant clinical advantage in the EECP treatment effectiveness in patients with angina. No significant difference was observed regarding EECP usefulness (P = 0.18) in the outcome of brachial artery diameter (2 studies). Based on the meta-analysis, the results indicate the safety and effectiveness of EECP in patients with angina pectoris and indicate the usefulness of this treatment in these patients. In general, the authors believe that the general conclusion in this regard requires some studies with a large sample size and a control group assignment.

scholarly journals INTRAMYOCARDIAL AUTOLOGOUS CD34+ CELL THERAPY FOR REFRACTORY ANGINA: A META-ANALYSIS

2017 ◽  
Vol 69 (11) ◽  
pp. 1064
Author(s):  
Poonam Velagapudi ◽  
Mohit Turagam ◽  
Dhaval Kolte ◽  
Sahil Khera ◽  
Herbert Aronow ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Meta Analysis ◽  
Refractory Angina

scholarly journals The Impact of Cell Therapy on Cardiovascular Outcomes in Patients With Refractory Angina

2019 ◽  
Vol 124 (12) ◽  
pp. 1786-1795 ◽  
Author(s):  
Daniel A. Jones ◽  
Deshan Weeraman ◽  
Martina Colicchia ◽  
Mohsin A. Hussain ◽  
Devanayegi Veerapen ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Randomized Controlled Trials ◽  
Odds Ratio ◽  
Exercise Tolerance ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Refractory Angina ◽  
Canadian Cardiovascular Society ◽  
Randomized Controlled ◽  
Canadian Cardiovascular Society Class

Rationale: Cell-based therapies are a novel potential treatment for refractory angina and have been found to improve markers of angina. However, the effects on mortality and major adverse cardiac events (MACE) have not been definitively investigated. Objective: To investigate the efficacy and safety of stem cell treatment compared with optimal medical treatment for refractory angina by conducting an updated meta-analysis, looking at clinical outcomes. Methods and Results: We performed a systematic review and meta-analysis of randomized controlled trials using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. A comprehensive search was performed of PubMed, EMBASE (Excerpta Medica database), Cochrane, ClinicalTrials.gov , Google Scholar databases of randomized controlled trials, and scientific session abstracts. Studies were deemed eligible if they met the following criteria: (1) full-length publications in peer-reviewed journals; (2) evaluated cell therapy use in patients with no further revascularisation options while on optimal medical treatment; (3) patients had ongoing angina, Canadian Cardiovascular Society class II—IV; and (4) included a placebo/control arm. We calculated risk ratios for all-cause mortality, combined MACE events. We assessed heterogeneity using χ 2 and I 2 tests. We identified 1191 citations with 8 randomized controlled trials meeting inclusion criteria involving 526 patients. Outcomes pooled were MACE, mortality, and indices of angina (angina episodes, Canadian Cardiovascular Society angina class, exercise tolerance, and antianginal medications). Our analysis showed a decreased risk of both MACE (odds ratio, 0.41; CI, 0.25−0.70) and mortality (odds ratio, 0.24; 95% CI, 0.10−0.60) in cell-treated patients compared with patients on maximal medical therapy. This was supported by improvements in surrogate end points of anginal episodes, use of antianginal medications, Canadian Cardiovascular Society class, and exercise tolerance. Conclusions: In addition to improvements in indices of angina, cell-based therapies improve cardiovascular outcomes (mortality/MACE) in patients with refractory angina. Given the premature termination of the phase III study, this supports the need for further definitive trials. Prospero Registration : URL: https://www.crd.york.ac.uk/prospero/ . Unique identifier: CRD42018084257.

Intramyocardial autologous CD34+ cell therapy for refractory angina: A meta-analysis of randomized controlled trials

2019 ◽  
Vol 20 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Poonam Velagapudi ◽  
Mohit Turagam ◽  
Dhaval Kolte ◽  
Sahil Khera ◽  
Omar Hyder ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Refractory Angina ◽  
Randomized Controlled

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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