LONG-TERM MORTALITY, READMISSION AND FUNCTIONAL OUTCOMES AMONG HOSPITAL SURVIVORS OF OUT-OF-HOSPITAL CARDIAC ARREST

2021 ◽  
Vol 37 (10) ◽  
pp. S7-S8
Author(s):  
C Fordyce ◽  
B Grunau ◽  
M Guan ◽  
N Hawkins ◽  
M Lee ◽  
...  
2003 ◽  
Vol 145 (5) ◽  
pp. 826-833 ◽  
Author(s):  
Johan Engdahl ◽  
Angela Bång ◽  
Jonny Lindqvist ◽  
Johan Herlitz

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Caro Codon ◽  
L Rodriguez Sotelo ◽  
J R Rey Blas ◽  
S O Rosillo Rodriguez ◽  
O Gonzalez Fernandez ◽  
...  

Abstract Background Data regarding long-term clinical outcomes after out-of-hospital cardiac arrest (OHCA) are scarce. Purpose To assess long-term mortality rate in OHCA patients, compare it with the general population age-specific mortality rate and identify relevant predictive factors. Methods All consecutive patients admitted to the Acute Cardiac Care Unit after OHCA from August 2007 to January 2019 and surviving until hospital discharge were included. All patients received targeted-temperature management according to our local protocol. Stepwise regression techniques and Cox proportional hazards models were used to investigate clinical variables related to long-term survival. The study population was divided into four quartiles according to their age and their mortality rate was compared with age-specific data from the Spanish National Statistics Institute. Results The final analysis included 201 patients. Mean age was 57.6±14.2 years and 168 (83.6%) were male. The majority of patients experienced witnessed arrests related to shockable rhythms (176, 87.6%). Median time to ROSC was 18 (IQR 12–27) minutes and 14 patients (7.0%) were discharged in a poor neurological condition (CPC 3–4). Thirty-six patients (17.9%) died after a median follow-up of 40.3 months (18.9–69.1). A prognostic multivariate Cox model was developed and is shown in Table 1. Mortality was mainly driven by neurologic (33.%), cardiovascular (30.6%) and oncologic (30.6%) causes. Annual mortality rate per 1000 patients was statistically superior to that in the general population among the first three age quartiles: 18.08 (6.78–48.16) vs 0.64; 29.62 (12.33–71.16) vs 3.30; 63.07 (33.94–117.22) vs 7.77. Nevertheless, no significant differences were observed among the oldest patients, ranging from 68.6 to 90.7 years: 70.93 (43.45–115.78) vs 54.95. Table 1. Cox proportional hazard model Variable Hazard Ratio Std. Err. p value 95% Confidence Interval Time from CA to CPR (per minute) 1.06 0.03 0.06 1.00–1.13 Non-shockable rhythm 2.93 1.11 0.01 1.39–6.16 Poor LVEF at discharge (per %) 1.03 0.01 0.01 1.01–1.06 Age at time of CA (per year) 1.04 0.01 0.01 1.01–1.06 CPC 3–4 at hospital discharge 3.50 1.43 <0.01 1.58–7.78 Figure 1 Conclusions OHCA survivors face significant mortality during follow-up, and its long term prognostic impact may be higher among younger patients. Age at the time of CA, time from CA to CPR, non-shockable rhythm, poor LVEF and poor neurological condition at discharge are independent predictors of long term mortality.


2020 ◽  
Vol 49 (1) ◽  
pp. 586-586
Author(s):  
Meredith Hickson ◽  
Madeline Winters ◽  
Nina Thomas ◽  
Monique Gardner ◽  
Matthew Kirschen ◽  
...  

2018 ◽  
Vol 9 (4_suppl) ◽  
pp. S184-S192 ◽  
Author(s):  
Matilde Winther-Jensen ◽  
Jesper Kjaergaard ◽  
Christian Hassager ◽  
Lars Køber ◽  
Freddy Lippert ◽  
...  

Objective: As the prevalence of malignancies in the general population increases, the odds of an out-of-hospital cardiac arrest (OHCA) patient having a history of cancer likewise increases, and the impact on post-cardiac arrest care and mortality is not well known. We aimed to investigate 30-day and 1-year mortality after successful resuscitation in patients with cancer prior to OHCA compared with OHCA patients without a previous cancer diagnosis. Methods: A cohort of 993 consecutive OHCA patients with successful resuscitation during 2007–2011 was included. Vital status was obtained from the Danish Civil Register, and cancer diagnoses from the Danish National Patient Register dating back to 1994. Primary endpoints were 30-day, 1-year and long-term mortality (no cancer: mean 811 days; cancer: mean 406 days), analysed by Cox regression. Functional status assessed by cerebral performance category at discharge and use of post-resuscitation care were secondary endpoints. Results: A total of 119 patients (12%) were diagnosed with cancer prior to OHCA. Mortality was higher in patients with cancer (30-day 69% vs. 58%, P=0.01); however, after adjustment for prognostic factors cancer was no longer associated with higher mortality (hazard ratio (HR)30 days 0.98, 95% confidence interval (CI) 0.76–1.27, P=0.88; HR1 year 0.99, 95% CI 0.78–1.27, P=0.96 HRend of follow-up 0.95, 95% CI 0.75–1.20, P=0.67). Favourable cerebral performance category scores in patients alive at discharge did not differ (cerebral performance category 1 or 2 n=310 (84%) vs. n=31 (84%), P=1). Conclusion: Cancer prior to OHCA was not associated with higher mortality in patients successfully resuscitated from OHCA when adjusting for confounders. Cancer prior to OHCA should be used with caution when performing prognostication after OHCA.


Resuscitation ◽  
2021 ◽  
Vol 160 ◽  
pp. 84-93
Author(s):  
Kirstie L. Haywood ◽  
Chen Ji ◽  
Tom Quinn ◽  
Jerry P. Nolan ◽  
Charles D. Deakin ◽  
...  

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