TRANSCRIPTOMIC HETEROGENEITY OF THE POSTNATAL ATRIOVENTRICULAR CONDUCTION SYSTEM AT A SINGLE-CELL RESOLUTION

2021 ◽  
Vol 37 (10) ◽  
pp. S5-S6
Author(s):  
Y Oh ◽  
N Munshi ◽  
K Kim
Keyword(s):  
Single Cell ◽  
Conduction System ◽  
Atrioventricular Conduction

scholarly journals Hypertrophic cardiomyopathy with paroxysmal atrial fibrillation misdiagnosed as WPW syndrome

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sang-Hoon Seol ◽  
Ki-Hun Kim ◽  
Jino Park ◽  
Yeo-Jeong Song ◽  
Dong-Kie Kim ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Hypertrophic Cardiomyopathy ◽  
Paroxysmal Atrial Fibrillation ◽  
Conduction System ◽  
Atrioventricular Conduction ◽  
Wpw Syndrome ◽  
Bypass Tract ◽  
Hypertrophied Myocardium

AbstractHypertrophic cardiomyopathy (HCM) is associated with an increased incidence of Wolff–Parkinson–White (WPW) syndrome and atrial fibrillation. However, a delta-like wide QRS can be observed in the hypertrophied myocardium. When considering the rarity of the paraseptal bypass tract (BT), the normal QRS axis suggests a higher possibility of HCM origin. Otherwise, there is no known electrocardiographic clue indicating a wide QRS differentiation between HCM and WPW syndrome. Moreover, the atriofascicular, nodofascicular/ventricular or fasciculoventricular BT should be differentiated. In this case, atrioventricular conduction system incidental injury revealed a wide QRS origin from the HCM, but this method should be avoided except in some selected cases.

Catheter technique for closed chest ablation of the atrioventricular conduction system in man

1982 ◽  
Vol 49 (4) ◽  
pp. 1012 ◽  
Author(s):  
John J. Gallagher ◽  
Robert H. Svenson ◽  
Jack H. Kasell ◽  
Lawrence D. German ◽  
Gust Bardy ◽  
...  
Keyword(s):  
Conduction System ◽  
Atrioventricular Conduction ◽  
Closed Chest ◽  
Catheter Technique

scholarly journals Time dependent changes in the functional properties of the atrioventricular conduction system in man.

Circulation ◽  
1975 ◽  
Vol 52 (6) ◽  
pp. 1012-1022 ◽  
Author(s):  
C P Reddy ◽  
A N Damato ◽  
M Akhtar ◽  
J B Ogunkelu ◽  
A R Caracta ◽  
...  
Keyword(s):  
Functional Properties ◽  
Conduction System ◽  
Atrioventricular Conduction ◽  
Time Dependent

The atrioventricular conduction system of the beef heart

1931 ◽  
Vol 49 (2) ◽  
pp. 167-192 ◽  
Author(s):  
John C. Cardwell ◽  
David I. Abramson
Keyword(s):  
Conduction System ◽  
Atrioventricular Conduction ◽  
Beef Heart

The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

1993 ◽  
Vol 105 (4) ◽  
pp. 985-991 ◽  
Author(s):  
R.G. Gourdie ◽  
N.J. Severs ◽  
C.R. Green ◽  
S. Rothery ◽  
P. Germroth ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Relative Abundance ◽  
Atrioventricular Node ◽  
Conduction System ◽  
Atrioventricular Conduction ◽  
Purkinje Fibre ◽  
Purkinje Fibres ◽  
Atrioventricular Bundle ◽  
Junctional Protein ◽  
Gap Junctional

Electrical coupling between heart muscle cells is mediated by specialised regions of sarcolemmal interaction termed gap junctions. In previous work, we have demonstrated that connexin42, a recently identified gap-junctional protein, is present in the specialised conduction tissues of the avian heart. In the present study, the spatial distribution of the mammalian homologue of this protein, connexin40, was examined using immunofluorescence, confocal scanning laser microscopy and quantitative digital image analysis in order to determine whether a parallel distribution occurs in rat. Connexin40 was detected by immunofluorescence in all main components of the atrioventricular conduction system including the atrioventricular node, atrioventricular bundle, and Purkinje fibres. Quantitation revealed that levels of connexin40 immunofluorescence increased along the axis of atrioventricular conduction, rising over 10-fold between atrioventricular node and atrioventricular bundle and a further 10-fold between atrioventricular bundle and Purkinje fibres. Connexin40 and connexin43, the principal gap-junctional protein of the mammalian heart, were co-localised within atrioventricular nodal tissues and Purkinje fibres. By applying a novel photobleach/double-labelling protocol, it was demonstrated that connexin40 and connexin43 are co-localised in precisely the same Purkinje fibre myocytes. A model, integrating data on the spatial distribution and relative abundance of connexin40 and connexin43 in the heart, proposes how myocyte-type-specific patterns of connexin isform expression account for the electrical continuity of cardiac atrioventricular conduction.

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