ATRIAL STRETCH-DEPENDENT TUMOR NECROSIS FACTOR-MEDIATED ADVERSE ATRIAL REMODELING AND ATRIAL ARRHYTHMIA INDUCIBILITY IN A MOUSE MODEL OF AORTIC REGURGITATION

2021 ◽  
Vol 37 (10) ◽  
pp. S3
Author(s):  
R Lakin ◽  
R Debi ◽  
N Polidovitch ◽  
W Chen ◽  
S Yakobov ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mouse Model ◽  
Aortic Regurgitation ◽  
Tumor Necrosis ◽  
Atrial Arrhythmia ◽  
Atrial Remodeling ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

Hypertension ◽  
2010 ◽  
Vol 56 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Marcia Venegas-Pont ◽  
Michaele B. Manigrasso ◽  
Samira C. Grifoni ◽  
Babbette B. LaMarca ◽  
Christine Maric ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Pressure ◽  
Tumor Necrosis Factor ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Systemic Lupus ◽  
Factor Α ◽  
Necrosis Factor

Anti-tumor necrosis factor-α therapy increases plaque burden in a mouse model of experimental atherosclerosis

2018 ◽  
Vol 277 ◽  
pp. 80-89 ◽  
Author(s):  
Raghav Oberoi ◽  
Ann-Kathrin Vlacil ◽  
Jutta Schuett ◽  
Florian Schösser ◽  
Harald Schuett ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mouse Model ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Experimental Atherosclerosis ◽  
Plaque Burden ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis

mBio ◽  
2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Zannatun Noor ◽  
Koji Watanabe ◽  
Mayuresh M. Abhyankar ◽  
Stacey L. Burgess ◽  
Erica L. Buonomo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mouse Model ◽  
Tumor Necrosis ◽  
Intestinal Epithelial ◽  
Necrosis Factor Alpha ◽  
Amebic Colitis ◽  
Tnf Α ◽  
Factor Alpha ◽  
Interleukin 25 ◽  
Necrosis Factor

ABSTRACT The parasite Entamoeba histolytica is a cause of diarrhea in infants in low-income countries. Previously, it was shown that tumor necrosis factor alpha (TNF-α) production was associated with increased risk of E. histolytica diarrhea in children. Interleukin-25 (IL-25) is a cytokine that is produced by intestinal epithelial cells that has a role in maintenance of gut barrier function and inhibition of TNF-α production. IL-25 expression was decreased in humans and in the mouse model of amebic colitis. Repletion of IL-25 blocked E. histolytica infection and barrier disruption in mice, increased gut eosinophils, and suppressed colonic TNF-α. Depletion of eosinophils with anti-Siglec-F antibody prevented IL-25-mediated protection. In contrast, depletion of TNF-α resulted in resistance to amebic infection. We concluded that IL-25 provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-α. IMPORTANCE The intestinal epithelial barrier is important for protection from intestinal amebiasis. We discovered that the intestinal epithelial cytokine IL-25 was suppressed during amebic colitis in humans and that protection could be restored in the mouse model by IL-25 administration. IL-25 acted via eosinophils and suppressed TNF-α. This work illustrates a previously unrecognized pathway of innate mucosal immune response.

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