scholarly journals Humanized Monoclonal Antibodies Against IgE Antibodies as Therapy for IgE-Mediated Coronary Syndromes: Are We There Yet?

2020 ◽  
Vol 36 (6) ◽  
pp. 816-819
Author(s):  
Nicholas G. Kounis ◽  
Ioanna Koniari ◽  
Grigorios Tsigkas ◽  
Periklis Davlouros
Keyword(s):  
Monoclonal Antibodies ◽  
Ige Antibodies ◽  
Coronary Syndromes ◽  
Ige Mediated ◽  
Humanized Monoclonal Antibodies

Elotuzumab in the treatment of relapsed and refractory multiple myeloma

2021 ◽  
Author(s):  
Sebastian Grosicki ◽  
Martyna Bednarczyk ◽  
Agnieszka Barchnicka ◽  
Olga Grosicka
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Clinical Studies ◽  
Mechanisms Of Action ◽  
Incurable Disease ◽  
The Us ◽  
Us Fda ◽  
Humanized Monoclonal Antibodies

Multiple myeloma (MM) is still considered an incurable disease. However, drugs with different mechanisms of action that can improve the efficiency of treatment offer hope. Still, there are concerns about an unacceptable increase in toxicity with such regimens. The results of recently published clinical studies of elotuzumab in combination with lenalidomide/dexamethasone or pomalidomide/dexamethasone confirm previous hopes to improve the effect of that treatment. Humanized monoclonal antibodies aimed at SLAMF7 stimulate natural killer cells to fight against MM cells. Elotuzumab used in combination with lenalidomide/dexamethasone or with pomalidomide/dexamethasone is approved by the US FDA to treat patients with relapsed and/or refractory MM. The article is a summary of the recent knowledge about the possibility of using elotuzumab in the treatment of relapsed and/or refractory MM and shows its potential uses in the future.

scholarly journals Pseudo-Anaphylactic Reactions to Pfizer BNT162b2 Vaccine: Report of 3 Cases of Anaphylaxis Post Pfizer BNT162b2 Vaccination

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 974
Author(s):  
Xin Rong Lim ◽  
Bernard Pui Leung ◽  
Carol Yee Leng Ng ◽  
Justina Wei Lynn Tan ◽  
Grace Yin Lai Chan ◽  
...  
Keyword(s):  
Cell Activation ◽  
Corticosteroid Treatment ◽  
Mast Cell Activation ◽  
Igg Antibodies ◽  
Ige Antibodies ◽  
Th2 Cytokine ◽  
Acute Reaction ◽  
Ige Mediated ◽  
Anaphylatoxin C3a ◽  
Over Time

Anaphylactic reactions were observed after Singapore’s national coronavirus disease 2019 (COVID-19) vaccination programme started in December 2020. We report the clinical and laboratory features of three patients in our institution who developed anaphylactic reactions after receiving the Pifzer BNT162b2 vaccine. IgM and IgG antibodies, but not IgE antibodies to the Pfizer BNT162b2 vaccine, were detected in all subjects. Similarly, mild to high elevated levels of anti-polyethylene glycol (PEG) IgG (1035–19709 U/mL, vs. vaccine-naive < 265 U/mL, vaccine-tolerant < 785 U/mL) and IgM (1682–5310 U/mL, vs. vaccine-naive < 1011 U/mL, vaccine-tolerant < 1007 U/mL) were detected in two out of three patients via commercial ELISA. High levels of serum anaphylatoxin C3a (79.0 ± 6.3 μg/mL, mean ± SD, vs. normal < 10 μg/mL) were observed in all three patients during the acute phase of the reaction, while tryptase levels, a marker of mast cell activation, were not elevated. Finally, one patient with the highest levels of anti-PEG IgG, IgM, and anti-Pfizer BNT162b2 IgG and IgM exhibited an enhanced Th2 cytokine serum profile during an acute reaction, with high levels of IL-4 (45.7 pg/mL, vs. vaccine-naive/tolerant < 2.30 pg/mL), IL-33 (86.4 pg/mL, vs. vaccine-naive/tolerant < 5.51 pg/mL) and IL-10 (22.9 pg/mL, vs. vaccine-naive/tolerant < 12.49 pg/mL) diminishing over time following corticosteroid treatment. Taken together, we propose these cases of anaphylaxis described are driven by a complement activation-related pseudoallergy (CAPRA), rather than classical IgE-mediated mechanisms.

Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys1

2003 ◽  
Vol 75 (12) ◽  
pp. 2106-2113 ◽  
Author(s):  
Tudor B??rsan ◽  
Bernard Hausen ◽  
John P. Higgins ◽  
Richard W. Hubble ◽  
Jochen Klupp ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Renal Allograft ◽  
Allograft Survival ◽  
Humanized Monoclonal Antibodies

scholarly journals Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα monoclonal antibodies

2020 ◽  
Author(s):  
Marat V. Khodoun ◽  
Suzanne C. Morris ◽  
Wen-Hai Shao ◽  
Crystal Potter ◽  
Elizabeth Angerman ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Food Allergy ◽  
Ige Mediated
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