scholarly journals FACTORS ASSOCIATED WITH CHANGES IN IMPAIRED QUALITY OF LIFE AMONG ATRIAL FIBRILLATION PATIENTS IN REAL-WORLD CLINICAL PRACTICE: INSIGHTS FROM THE PROSPECTIVE SPRINT-AF REGISTRY

2019 ◽  
Vol 35 (10) ◽  
pp. S144-S145
Author(s):  
A. Ha ◽  
C. Labos ◽  
A. Ha ◽  
P. Dorian ◽  
J. MANCINI ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Real World ◽  
Factors Associated ◽  
Impaired Quality

scholarly journals Clinically Meaningful Change in Quality of Life and Associated Factors Among Older Patients With Atrial Fibrillation

2020 ◽  
Vol 9 (18) ◽  
Author(s):  
Hawa O. Abu ◽  
Jane S. Saczynski ◽  
Jordy Mehawej ◽  
Mayra Tisminetzky ◽  
Catarina I. Kiefe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Older Patients ◽  
Logistic Models ◽  
Life Questionnaire ◽  
Meaningful Change ◽  
Patient Centered ◽  
Factors Associated ◽  
Fair Poor

Background Among older patients with atrial fibrillation, there are limited data examining clinically meaningful changes in quality of life (QoL). We examined the extent of, and factors associated with, clinically meaningful change in QoL over 1‐year among older adults with atrial fibrillation. Methods and Results Patients from cardiology, electrophysiology, and primary care clinics in Massachusetts and Georgia were enrolled in a cohort study (2015–2018). The Atrial Fibrillation Effect on Quality‐of‐Life questionnaire was used to assess overall QoL and across 3 subscales: symptoms, daily activities, and treatment concern. Clinically meaningful change in QoL (ie, difference between 1‐year and baseline QoL score) was categorized as either a decline (≤−5.0 points), no clinically meaningful change (−5.0 to +5.0 points), or an increase (≥+5.0 points). Ordinal logistic models were used to examine factors associated with QoL changes. Participants (n=1097) were on average 75 years old, 48% were women, and 87% White. Approximately 40% experienced a clinically meaningful increase in QoL and 1 in every 5 patients experienced a decline in QoL. After multivariable adjustment, women, non‐Whites, those who reported depressive and anxiety symptoms, fair/poor self‐rated health, low social support, heart failure, or diabetes mellitus experienced clinically meaningful declines in QoL. Conclusions These findings provide insights to the magnitude of, and factors associated with, clinically meaningful change in QoL among older patients with atrial fibrillation. Assessment of comorbidities and psychosocial factors may help identify patients at high risk for declining QoL and those who require additional surveillance to maximize important clinical and patient‐centered outcomes.

Home versus outpatient pulmonary rehabilitation in COPD: a propensity-matched cohort study

Thorax ◽  
2019 ◽  
Vol 74 (10) ◽  
pp. 996-998 ◽  
Author(s):  
Claire Marie Nolan ◽  
Djeya Kaliaraju ◽  
Sarah Elizabeth Jones ◽  
Suhani Patel ◽  
Ruth Barker ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Clinical Practice ◽  
Real World ◽  
Treatment Strategy ◽  
Pulmonary Rehabilitation ◽  
Standard Of Care ◽  
Matched Cohort ◽  
Home Based

Home-based exercise has been proposed as an equivalent treatment strategy to supervised outpatient pulmonary rehabilitation (PR), but it is not known whether its implementation into clinical practice produces similar benefits to those observed in trials. We compared the real-world responses of 154 patients with COPD undergoing home-based exercise with a matched group attending supervised PR. We observed smaller improvements in exercise capacity with home-based exercise compared with PR, but similar improvements in quality of life. We propose that supervised PR remains the standard of care, with home-based exercise a less effective alternative for those unable to attend PR.

scholarly journals Health-related quality of life (QoL) in patients with advanced melanoma receiving immunotherapies in real-world clinical practice settings

2020 ◽  
Vol 29 (10) ◽  
pp. 2651-2660
Author(s):  
Richard W. Joseph ◽  
Frank Xiaoqing Liu ◽  
Alicia C. Shillington ◽  
Cynthia P. Macahilig ◽  
Scott J. Diede ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Real World ◽  
Repeated Measures ◽  
Advanced Melanoma ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eq Vas

Abstract Background Pembrolizumab (PEMBRO) and ipilimumab + nivolumab (IPI + NIVO) are approved advanced melanoma (AM) immunotherapies. To address limited health-related quality of life (QoL) real-world evidence with immunotherapies in AM, we compared QoL in AM patients receiving either treatment in clinical practice. Methods A prospective US observational study enrolled adult AM patients initiating first-line PEMBRO or IPI + NIVO between June 2017 and March 2018. Endpoints included the QLQ-C30 global health score (GHS) and EuroQol visual analog scale (EQ-VAS) scores. Mean changes were compared using repeated measures mixed-effects models and are presented covariate adjusted. Results 225 PEMBRO and 187 IPI + NIVO patients were enrolled. From baseline through week 24, PEMBRO was associated with 3.2 mean GHS score increase (95% CI 0.5, 5.9; p = .02), while no change was observed with IPI + NIVO; 0.2 (95% CI − 2.6, 3.0; p = 0.87). Among objective treatment-responders, GHS scores associated with PEMBRO increased 6.0 (95% CI 3.1, 8.8; p < .0001); IPI + NIVO patients increased 3.8 (95% CI 0.8, 6.9; p = .01). In treatment non-responders, IPI + NIVO was associated with GHS/QoL deterioration of − 3.7 (95% CI − 6.8, − 0.6; p = .02), PEMBRO non-responders demonstrated no change; 0.7 (95% CI − 2.3, 3.7; p = 0.6). Between treatments, PEMBRO patients increased 2.6 greater in EQ-VAS (95% CI 0.6, 4.5; p = .01) vs IPI + NIVO at 24 weeks. Conclusions PEMBRO was associated with better 24-week QoL compared to IPI + NIVO in actual clinical practice settings. Real-world data has known limitations, but with further confirmation these results may have implications for treatment selection.

scholarly journals Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation

2020 ◽  
Vol 13 (5) ◽  
Author(s):  
Benjamin A. Steinberg ◽  
DaJuanicia N. Holmes ◽  
Karen Pieper ◽  
Larry A. Allen ◽  
Paul S. Chan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Health Related Quality ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related

scholarly journals Impaired quality of life in patients with intermittent atrial fibrillation

2015 ◽  
Author(s):  
Cem Nazli ◽  
Nihan Kahya Eren ◽  
Selcen Yakar Tuluce ◽  
Idil Gokcen Koçagra Yagiz ◽  
Baris Kilicaslan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Impaired Quality

P1035Factors associated with quality-of-life improvement after catheter ablation of atrial fibrillation: insights from the Kansai Plus Atrial Fibrillation (KPAF) registry

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Kanda ◽  
M Masuda ◽  
S Shizuta ◽  
A Kobori ◽  
K Inoue ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Heart Rate ◽  
Multivariate Analysis ◽  
Catheter Ablation ◽  
Left Atrial ◽  
Left Atrial Diameter ◽  
Factors Associated ◽  
Af Recurrence

Abstract Background Improving the quality of life (QoL) is one of the main purposes of catheter ablation (CA) of persistent atrial fibrillation (AF). Factors associated with QoL improvement after CA of AF patients have not been clarified. The Kansai Plus Atrial Fibrillation (KPAF) Registry is a multi-center registry enrolling more than 5,000 consecutive patients undergoing the first radiofrequency catheter ablation of AF. Purpose The aim of this study was to investigate the QoL change after AF ablation and its associated factors. Methods A total of 2030 patients in whom the QoL score was assessed before and one year after the ablation were enrolled from the KPAF registry (age 64±10 years, 75% male, paroxysmal 66%, CHADS2 score 1.1±1.1). The QoL was evaluated using the AF specific QoL evaluation method (AFQLQ), which scores the patient QoL within a range of 0–98 points. Results Overall, catheter ablation showed a significant increase in the AFQLQ score (68±19 vs. 86±13 points, P<0.01). AF recurrence was observed in 372 cases (18%) during a 1-year follow-up period. A multivariate analysis showed that AF recurrence, symptomatic AF, long AF duration, high preprocedural heart rate (>110 bpm) and small left atrial diameter were independent predictors of a QoL improvement defined as a >10% score increase. Multivariate analysis Conclusions CA of AF significantly improved the QoL. AF recurrence was one of the strong factors associated with QoL improvement. Symptomatic AF, long AF duration, high preprocedural heart rate and small left atrial diameter were independent predictors of QoL improvement.

Sign in / Sign up

Export Citation Format

Share Document