ASSOCIATION OF PLATELET ACTIVITY WITH CIRCULATING LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND COGNITIVE FUNCTION: A CROSS-SECTIONAL STUDY

2019 ◽  
Vol 35 (10) ◽  
pp. S122
Author(s):  
J. Bélanger ◽  
J. Le Blanc ◽  
S. Fleury ◽  
M. Welman ◽  
I. Boukhatem ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Platelet Activity ◽  
Cross Sectional ◽  
Circulating Levels

scholarly journals Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment

2021 ◽  
Vol 8 ◽  
Author(s):  
Jean-Christophe Bélanger ◽  
Véronique Bouchard ◽  
Jessica Le Blanc ◽  
Louisia Starnino ◽  
Mélanie Welman ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Platelet Activation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Cognitive Outcomes ◽  
Activity Levels ◽  
Platelet Activity ◽  
Cross Sectional ◽  
The Relationship

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decline. Given these apparently opposing effects of platelet activation on cognitive health, we investigated whether BDNF levels intercede in the relationship between platelet activation and cognitive function; and whether this relationship is moderated by the presence of CAD.Methods: In this cross-sectional study, 1,280 participants with (n = 673) and without CAD (n = 607) completed the Montreal Cognitive Assessment (MoCA). Plasma BDNF and soluble P-selectin (a marker of platelet activity) levels were assessed using multiplex flow cytometry.Results: In a mediation model, platelet activity was correlated with higher plasma BDNF concentrations (b = 0.53, p < 0.0001). The relationship between sP-selectin and BDNF concentrations was stronger for individuals without CAD (b = 0.71, p < 0.0001) than for CAD participants (b = 0.43, p < 0.0001; pinteraction <0.0001). Higher BDNF concentrations were associated with higher MoCA scores (b = 0.26, p = 0.03). The overall effect of platelet activity on cognitive performance was non-significant (total effect: b = −0.12, p = 0.13), and became significant when accounting for BDNF as a mediating factor (direct effect: b = −0.26, p = 0.01). This resulted in a positive indirect effect of platelet activity (via BDNF) on MoCA scores (b = 0.14, CI 95% 0.02–0.30), that was smaller in CAD participants than in non-CAD participants [Δ −0.07 (95% CI −0.14 to −0.01)].Conclusions: BDNF released from activated platelets could be a mitigating factor in a negative association between platelet activity and cognitive function.

Evaluation of cytokines, oxidative stress markers and brain-derived neurotrophic factor in patients with fibromyalgia – A controlled cross-sectional study

Cytokine ◽  
2016 ◽  
Vol 84 ◽  
pp. 25-28 ◽  
Author(s):  
Aline Ranzolin ◽  
Angela Luzia Branco Pinto Duarte ◽  
Markus Bredemeier ◽  
Cláudio Antônio da Costa Neto ◽  
Bruna Maria Ascoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Oxidative Stress Markers ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stress Markers

Association between brain-derived neurotrophic factor (BDNF) level and perceptual thresholds in middle-aged women: a cross-sectional study

Maturitas ◽  
2019 ◽  
Vol 124 ◽  
pp. 170-171
Author(s):  
Fernanda Vargas Ferreira ◽  
Charles Francisco Ferreira ◽  
Mona Lúcia Dall’Agno ◽  
Jéssica Zandoná ◽  
Joana Zanotti ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Bdnf Level ◽  
Cross Sectional

Brain-derived neurotrophic factor (BDNF) is not related to climacteric symptoms in healthy women: a cross-sectional study

Maturitas ◽  
2019 ◽  
Vol 124 ◽  
pp. 171
Author(s):  
Fernanda Vargas Ferreira ◽  
Charles Francisco Ferreira ◽  
Mona Lúcia Dall’Agno ◽  
Jéssica Zandoná ◽  
Joana Zanotti ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Climacteric Symptoms ◽  
Cross Sectional ◽  
Healthy Women

scholarly journals Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

2020 ◽  
Vol 16 (5) ◽  
pp. 1049-1056
Author(s):  
Jan K. Nowak ◽  
Mariusz Szczepanik ◽  
Magdalena Trypuć ◽  
Andrzej Pogorzelski ◽  
Waldemar Bobkowski ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neuropeptide Y ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Clinical Correlates

Fine or Gross Motor Index as a Simple Tool for Predicting Cognitive Impairment in Elderly People: Findings from The Irish Longitudinal Study on Ageing (TILDA)

2021 ◽  
pp. 1-8
Author(s):  
Xiao Liu ◽  
Ayiguli Abudukeremu ◽  
Yuan Jiang ◽  
Zhengyu Cao ◽  
Maoxiong Wu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Impairment ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Simple Tool

Background: Several kinds of motor dysfunction can predict future cognitive impairment in elderly individuals. However, the ability of the fine motor index (FINEA) and gross motor index (GROSSA) to predict the risk of cognitive impairment has not been assessed. Objective: We investigated the associations between FINEA/GROSSA and cognitive impairment. Methods: The data of 4,745 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). We first assessed the correlation between the FINEA GROSSA and MMSE in a cross-sectional study. Then, we further investigated the predictive role of the incidence of cognitive impairment in a prospective cohort study. Results: We found that both FINEA and GROSSA were negatively correlated with MMSE in both the unadjusted (FINEA: B = –1.00, 95%confidence intervals (CI): –1.17, –0.83, t = –11.53, p <  0.001; GROSSA: B = –0.85, 95%CI: –0.94, –0.76, t = –18.29, p <  0.001) and adjusted (FINEA: B = –0.63, 95%CI: –0.79, –0.47, t = –7.77, p <  0.001; GROSSA: B = –0.57, 95%CI: –0.66, –0.48, t = –12.61, p <  0.001) analyses in a cross-sectional study. In a prospective cohort study, both high FINEA and high GROSSA were associated with an increased incidence of cognitive function impairment (FINEA: adjusted odds ratios (OR) = 2.35, 95%CI: 1.05, 5.23, p = 0.036; GROSSA adjusted OR = 3.00, 95%CI: 1.49, 6.03, p = 0.002) after 2 years of follow-up. Conclusion: Higher FINEA and GROSSA scores were both associated with an increased incidence of cognitive impairment. FINEA or GROSSA might be a simple tool for identifying patients with cognitive impairment.

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