scholarly journals CARDIORESPIRATORY IMPACT OF E-VAPOR AEROSOLS AND CIGARETTE SMOKE EXPOSURE IN THE APOE KNOCKOUT MOUSE MODEL

2019 ◽  
Vol 35 (10) ◽  
pp. S160-S161
Author(s):  
J. Szostak ◽  
E. Wong ◽  
B. Titz ◽  
F. Martin ◽  
F. Paneni ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Knockout Mouse ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Knockout Mouse Model ◽  
Apoe Knockout Mouse

scholarly journals The effect of AVE 0991, nebivolol and doxycycline on inflammatory mediators in an apoE-knockout mouse model of atherosclerosis

2012 ◽  
Vol 18 (10) ◽  
pp. BR389-BR393 ◽  
Author(s):  
Jacek Jawien ◽  
Justyna Toton-Zuranska ◽  
Katarzyna Kus ◽  
Malgorzata Pawlowska ◽  
Rafal Olszanecki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Inflammatory Mediators ◽  
Knockout Mouse ◽  
Knockout Mouse Model ◽  
Apoe Knockout Mouse

scholarly journals Chronic Cigarette Smoke Exposure Primes NK Cell Activation in a Mouse Model of Chronic Obstructive Pulmonary Disease

2010 ◽  
Vol 184 (8) ◽  
pp. 4460-4469 ◽  
Author(s):  
Gregory T. Motz ◽  
Bryan L. Eppert ◽  
Brian W. Wortham ◽  
Robyn M. Amos-Kroohs ◽  
Jennifer L. Flury ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Mouse Model ◽  
Pulmonary Disease ◽  
Cigarette Smoke ◽  
Cell Activation ◽  
Nk Cell ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Cigarette exposure induces changes in maternal vascular function in a pregnant mouse model

2010 ◽  
Vol 298 (5) ◽  
pp. R1249-R1256 ◽  
Author(s):  
Robin E. Gandley ◽  
Arun Jeyabalan ◽  
Ketaki Desai ◽  
Stacy McGonigal ◽  
Jennifer Rohland ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Smoke Exposure ◽  
Renal Arteries ◽  
Growth Restriction ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Pregnant Mice

Smoking is associated with multiple adverse pregnancy outcomes, including fetal growth restriction. The objective of this study was to determine whether cigarette smoke exposure during pregnancy in a mouse model affects the functional properties of maternal uterine, mesenteric, and renal arteries as a possible mechanism for growth restriction. C57Bl/CJ mice were exposed to whole body sidestream smoke for 4 h/day. Smoke particle exposure was increased from day 4 of gestation until late pregnancy ( day 16–19), with mean total suspended particle levels of 63 mg/m3, representative of moderate-to-heavy smoking in humans. Uterine, mesenteric, and renal arteries from late-pregnant and virgin mice were isolated and studied in a pressure-arteriograph system ( n = 23). Plasma cotinine was measured by ELISA. Fetal weights were significantly reduced in smoke-exposed compared with control fetuses (0.88 ± 0.1 vs. 1.0 ± 0.08 g, P < 0.02), while litter sizes were not different. Endothelium-mediated relaxation responses to methacholine were significantly impaired in both the uterine and mesenteric vasculature of pregnant mice exposed to cigarette smoke during gestation. This difference was not apparent in isolated renal arteries from pregnant mice exposed to cigarette smoke; however, relaxation was significantly reduced in renal arteries from smoke-exposed virgin mice. In conclusion, we found that passive cigarette smoke exposure is associated with impaired vascular relaxation of uterine and mesenteric arteries in pregnant mice. Functional maternal vascular perturbations during pregnancy, specifically impaired peripheral and uterine vasodilation, may contribute to a mechanism by which smoking results in fetal growth restriction.

scholarly journals Long-Term Cigarette Smoke Exposure in a Mouse Model of Ciliated Epithelial Cell Function

2010 ◽  
Vol 43 (6) ◽  
pp. 635-640 ◽  
Author(s):  
Samantha M. Simet ◽  
Joseph H. Sisson ◽  
Jacqueline A. Pavlik ◽  
Jane M. DeVasure ◽  
Craig Boyer ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Cell Function ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Ciliated Epithelial Cell

Cigarette Smoke Exposure Triggers Autophagy-Mediated Ovarian Follicle Loss in a Mouse Model.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 37-37
Author(s):  
Anne Marie Gannon ◽  
Martin Stampfli ◽  
Warren G. Foster
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Ovarian Follicle ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

scholarly journals Comparison and evaluation of two different methods to establish the cigarette smoke exposure mouse model of COPD

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jiaze Shu ◽  
Defu Li ◽  
Haiping Ouyang ◽  
Junyi Huang ◽  
Zhen Long ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation

2009 ◽  
Vol 206 (2) ◽  
pp. 355-361 ◽  
Author(s):  
Kae Nakamura ◽  
Takeshi Sasaki ◽  
Xian Wu Cheng ◽  
Akihisa Iguchi ◽  
Kohji Sato ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Acute Inflammation ◽  
Pleiotropic Effect ◽  
Knockout Mouse Model ◽  
Plaque Disruption ◽  
Apoe Knockout Mouse
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