scholarly journals Heart Transplantation for End-Stage Cardiac Sarcoidosis: Increasingly Used With Excellent Results

2018 ◽  
Vol 34 (8) ◽  
pp. 956-958 ◽  
Author(s):  
Mustafa Toma ◽  
David Birnie
Keyword(s):  
Heart Transplantation ◽  
Cardiac Sarcoidosis ◽  
End Stage

Cardiac sarcoidosis in the donor heart without extracardiac manifestations

2021 ◽  
Vol 14 (4) ◽  
pp. e241902
Author(s):  
Mohammad Al-Ani ◽  
Mohamad Badie Taha ◽  
Brian D Stewart ◽  
Gabrielle S Graves ◽  
Mustafa M Ahmed ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Functional Imaging ◽  
Heart Block ◽  
Cardiac Sarcoidosis ◽  
Systolic Dysfunction ◽  
Donor Heart ◽  
Post Transplantation ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
End Stage

A middle-aged woman who received heart transplantation for end-stage sarcoid cardiomyopathy developed recurrent cardiac sarcoidosis in the donor heart. She presented 5 years post-transplantation with heart block and systolic dysfunction, without extracardiac involvement. Her disease was unresponsive to corticosteroids. Routine functional imaging may help identify such recurrences.

Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis

2013 ◽  
Vol 45 (6) ◽  
pp. 2384-2386 ◽  
Author(s):  
D. Perkel ◽  
L.S.C. Czer ◽  
R.P. Morrissey ◽  
A. Ruzza ◽  
M. Rafiei ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Cardiac Sarcoidosis ◽  
End Stage Heart Failure ◽  
End Stage

Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis

2015 ◽  
Vol 47 (6) ◽  
pp. 2075-2077 ◽  
Author(s):  
Christina S. Thornton ◽  
Jason D. Wesolosky ◽  
Riley Hartmann ◽  
Andrea Letourneau ◽  
Jocelyn Slemko
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Cardiac Sarcoidosis ◽  
End Stage Heart Failure ◽  
End Stage

Using the Theory of Planned Behavior to Explore Pediatric Heart Transplant Recipients’ Dietary Behavior

2018 ◽  
Vol 25 (2) ◽  
pp. 43-52
Author(s):  
Jo Wray ◽  
Claire Orrells ◽  
Helen Latch ◽  
Michael Burch
Keyword(s):  
Theory Of Planned Behavior ◽  
Heart Transplantation ◽  
Planned Behavior ◽  
Vegetable Consumption ◽  
Graft Loss ◽  
Dietary Behaviors ◽  
Food Groups ◽  
Tpb Model ◽  
Eating Fruit ◽  
End Stage

Abstract. Heart transplantation is the treatment of choice for children with end-stage heart disease. Coronary artery vasculopathy is, however, a significant morbidity and leading cause of late graft loss, and hyperlipidemia a risk factor for its development. Improving diet in this population could have important benefits for patients. We wanted to understand what influences decisions about food intake in this patient group. Dietary intentions and behavior were examined using a questionnaire based on the Theory of Planned Behavior (TPB) with 67 children who had undergone heart transplantation at least 12 months previously. The TPB model was significant for both healthy and unhealthy dietary behaviors, explaining 55% and 38% of the variance, respectively. Ten percent of children reported not eating any fruit and/or vegetables in the previous week and only 29% reported eating fruit and/or vegetables every day. The Theory of Planned Behavior provides a framework for explaining some specific dietary behaviors related to individual food groups in children who have undergone heart transplantation. These preliminary data support using this approach to inform the development of interventions to improve fruit and vegetable consumption but the approach may be less useful for explaining and developing interventions to reduce the consumption of unhealthy foods.

Coronary sinus catalase and ceruloplasmin levels predict all-cause mortality in patients with end-stage heart failure awaiting heart transplantation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
W Szczurek ◽  
M Gasior ◽  
M Skrzypek ◽  
G Kubiak ◽  
A Kuczaj ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Coronary Sinus ◽  
Public Institution ◽  
Funding Source ◽  
Organ Shortage ◽  
Number Of Patients ◽  
End Stage ◽  
Medical University

Abstract   Background, As a consequence of the worldwide increase in life expectancy and due to significant progress in the pharmacological and interventional treatment of heart failure (HF), the proportion of patients that reach an advanced phase of disease is steadily growing. Hence, more and more numerous group of patients is qualified to the heart transplantation (HT), whereas the number of potential heart donors has remained invariable since years. It contributes to deepening in disproportion between the demand for organs which can possibly be transplanted and number of patients awaiting on the HT list. Therefore, accurate identification of patients who are most likely to benefit from HT is imperative due to an organ shortage and perioperative complications. Purpose The aim of this study was to identify the factors associated with reduced survival during a 1.5-year follow-up in patients with end-stage HF awating HT. Method We propectively analysed 85 adult patients with end-stage HF, who were accepted for HT at our institution between 2015 and 2016. During right heart catheterization, 10 ml of coronary sinus blood was additionally collected to determine the panel of oxidative stress markers. Oxidative-antioxidant balance markers included glutathione reductase (GR), glutathione peroxidase (GPx), glutathione transferase (GST), superoxide dismutase (SOD) and its mitochondrial isoenzyme (MnSOD) and cytoplasmic (Cu/ZnSOD), catalase (CAT), malondialdehyde (MDA), hydroperoxides lipid (LPH), lipofuscin (LPS), sulfhydryl groups (SH-), ceruloplasmin (CR). The study protocol was approved by the ethics committee of the Medical University of Silesia in Katowice. The endpoint of the study was mortality from any cause during a 1.5 years follow-up. Results The median age of the patients was 53.0 (43.0–56.0) years and 90.6% of them were male. All included patients were treated optimally in accordance with the guidelines of the European Society of Cardiology. Mortality rate during the follow-up period was 40%. Multivariate logistic regression analysis showed that ceruloplasmin (odds ratio [OR] = 0.745 [0.565–0.981], p=0.0363), catalase (OR = 0.950 [0.915–0.98], p=0.0076), as well as high creatinine levels (OR = 1.071 [1.002–1.144], p=0.0422) were risk factors for death during 1.5 year follow-up. Conclusions Coronary sinus lower ceruloplasmin and catalase levels, as well as higher creatinine level are independently associated with death during 1.5 year follow-up. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Medical University of SIlesia, Katowice, POland

Abstract 18639: Implantable Cardioverter-defibrillator Use is Associated With Improved Survival on the Waitlist for Heart Transplantation: A UNOS/ OPTN Registry Analysis of 36,397 Patients

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Kairav Vakil ◽  
Rebecca Cogswell ◽  
Sue Duval ◽  
Wayne Levy ◽  
Peter Eckman ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Cox Regression ◽  
Left Ventricular ◽  
Total Artificial Heart ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Cox Regression Analysis ◽  
End Stage ◽  
The Impact ◽  
Waitlist Mortality

Background: Current guidelines do not support routine use of implantable cardioverter-defibrillators (ICDs) in patients (pts) with end-stage heart failure (HF), unless these pts are awaiting advanced HF therapies such as left ventricular assist devices (LVADs) or a heart transplantation (HT). Whether ICDs improve survival in end-stage HF pts awaiting HT has not been previously examined in a large, multicenter cohort. Hypothesis: Presence of ICDs at time of listing for HT is associated with lower waitlist mortality. Methods: The United Network for Organ Sharing registry was used to identify adults (≥18 years) listed for HT between January 4, 1999 & September 30, 2014. Pts with congenital heart disease, total artificial heart, restrictive cardiomyopathy, prior HT, or missing covariates were excluded. Cox regression analysis was used to assess the impact of an ICD at the time of listing on waitlist mortality. Results: The analysis included 36,397 pts (mean age 53±12; 77% males) listed for HT. The prevalence of ICDs at listing has steadily increased over time before reaching a plateau in 2006 (27% in 1999, and range 76-82% between 2006-2014). In the unadjusted model, ICD use was associated with a 36% reduction in waitlist mortality (HR 0.64, 95% CI 0.60-0.68, p<0.001). After adjustment for covariates such as age, sex, race, creatinine, ischemic cardiomyopathy, and listing status, this association was nearly unchanged (HR 0.67, 95% CI 0.62-0.72, p<0.001). Test for interaction by listing era (pre- and post-2006) was non-significant (p=0.28). In the final adjusted model, that included listing era and LVAD status in addition to the above listed covariates, ICD use continued to remain associated with a mortality benefit on the waitlist for HT (HR 0.84, 95% CI 0.78-0.91, p<0.001). Conclusion: ICDs are increasingly prevalent in pts listed for HT; however many pts are still listed for HT without these devices. The presence of an ICD at the time of listing is associated with lower mortality on the waitlist. Although the magnitude of ICD efficacy diminishes slightly, its benefit continues to remain significant even after adjustment for listing era and LVAD use. Further analyses are required to identify specific sub-groups of pts where ICD use is most beneficial and appropriate.

scholarly journals Neurologic complications after heart transplantation

2002 ◽  
Vol 60 (2A) ◽  
pp. 192-197 ◽  
Author(s):  
Suzana M.F. Malheiros ◽  
Dirceu R. Almeida ◽  
Ayrton R. Massaro ◽  
Adauto Castelo ◽  
Rosiane V.Z. Diniz ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Prospective Observational Study ◽  
Cord Compression ◽  
Orthotopic Heart Transplantation ◽  
Cns Infection ◽  
Neurologic Complications ◽  
Neurologic Disability ◽  
End Stage ◽  
Neurologic Event

OBJECTIVE: Neurologic complications are known as important cause of morbidity and mortality in orthotopic heart transplantation. Our aim was to identify the frequency and outcome of neurologic complications after heart transplantation in a prospective observational study. METHOD: From September 93 to September 99, as part of our routine heart transplantation protocol all patients with end-stage cardiac failure were evaluated by the same neurologist before and at the time of any neurologic event (symptom or complaint) after transplantation. RESULTS: Out of 120 candidates evaluated, 62 were successfully transplanted (53 male; median age 45.5 years, median follow-up 26.8 months). Fifteen patients (24%) had ischemic, 22 (35%) idiopathic, 24 (39%) Chagas' disease and 1 (2%) had congenital cardiomyopathy. Neurologic complications occurred in 19 patients (31%): tremor, severe headache, transient encephalopathy and seizures related to drug toxicity or metabolic changes in 13; peripheral neuropathy in 4; and spinal cord compression in two (metastatic prostate cancer and epidural abscess). No symptomatic postoperative stroke was observed. CONCLUSIONS: Although frequent, neurologic complications were seldom related to persistent neurologic disability or death. Most of the complications resulted from immunosuppression, however, CNS infection was rare. The absence of symptomatic stroke in our series may be related to the lower frequency of ischemic cardiomyopathy.

170 Heart Transplantation in 11 Patients with End Stage Heart Failure Caused by Muscular Dystrophy

2012 ◽  
Vol 31 (4) ◽  
pp. S66
Author(s):  
U. Fuchs ◽  
U. Schulz ◽  
B. Schulze ◽  
A. Zittermann ◽  
K. Hakim-Meibodi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Muscular Dystrophy ◽  
Heart Transplantation ◽  
End Stage Heart Failure ◽  
End Stage
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