scholarly journals DIRECT EFFECTS OF EMPAGLIFLOZIN ON EXTRACELLULAR MATRIX REMODELING IN HUMAN CARDIAC FIBROBLASTS: NOVEL TRANSLATIONAL CLUES TO EMPA-REG OUTCOME

2017 ◽  
Vol 33 (10) ◽  
pp. S169 ◽  
Author(s):  
S. Kang ◽  
S. Verma ◽  
G. Teng ◽  
D. Belke ◽  
D. Svystonyuk ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cardiac Fibroblasts ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Direct Effects ◽  
Human Cardiac Fibroblasts

Abstract 521: Cardiac Fibroblasts are Activated During Postnatal Extracellular Matrix Remodeling

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Luis Hortells ◽  
Iñigo Valiente ◽  
Nivedhitha Velayutham ◽  
Katherine E Yutzey
Keyword(s):  
Extracellular Matrix ◽  
Cardiac Fibroblasts ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

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