CARDIOVASCULAR SUSCEPTIBILITY TO ISCHEMIC MYOCARDIAL INJURY IN MALE AND FEMALE RAT OFFSPRING BORN GROWTH RESTRICTED

2016 ◽  
Vol 32 (10) ◽  
pp. S276-S277
Author(s):  
A. Shah ◽  
N. Matsumura ◽  
A. Quon ◽  
J.S. Morton ◽  
J.R. Dyck ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring

Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia

2017 ◽  
Vol 131 (17) ◽  
pp. 2303-2317 ◽  
Author(s):  
Amin Shah ◽  
Nobutoshi Matsumura ◽  
Anita Quon ◽  
Jude S. Morton ◽  
Jason R.B. Dyck ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Myocardial Injury ◽  
Adult Life ◽  
Left Ventricular ◽  
Male Offspring ◽  
Prenatal Hypoxia ◽  
Internal Diameter ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring

Intrauterine growth restriction (IUGR) following prenatal hypoxia exposure leads to a higher risk of developing cardiovascular disease (CVD) in later life. Our aim was to evaluate cardiac susceptibility and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O2) or hypoxia (11% O2) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic data revealed that both sexes had systolic dysfunction following MI surgery, independent of prenatal hypoxia. Male offspring exposed to prenatal hypoxia, however, had left ventricular dilatation, global dysfunction, and signs of diastolic dysfunction following MI surgery as evident by increased left ventricular internal diameter (LVID) during diastole (MI effect, P<0.01), Tei index (MI effect, P<0.001), and E/E′ ratio (prenatal hypoxia or MI effect, P<0.01). In contrast, diastolic dysfunction in female offspring was not as evident. Cardiac superoxide levels increased only in prenatal hypoxia exposed male offspring. Cardiac sarcoendoplasmic reticulum Ca2+-ATPase2a (SERCA2a) levels, a marker of cardiac injury and dysfunction, decreased in both male and female MI groups independent of prenatal hypoxia. Prenatal hypoxia increased cardiac ryanodine receptor 2 (RYR2) protein levels, while MI reduced RYR2 in only male offspring. In conclusion, male offspring exposed to prenatal hypoxia had an increased susceptibility to ischemic myocardial injury involving cardiac phenotypes similar to heart failure involving diastolic dysfunction in adult life compared with both offspring from healthy pregnancies and their female counterparts.

scholarly journals Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring

2020 ◽  
Vol 718 ◽  
pp. 134700 ◽  
Author(s):  
John T. Madden ◽  
Shannon M. Thompson ◽  
Christy M. Magcalas ◽  
Jennifer L. Wagner ◽  
Derek A. Hamilton ◽  
...  
Keyword(s):  
Adult Male ◽  
Dorsal Hippocampus ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Gabaergic Interneurons ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring ◽  
Prenatal Alcohol

scholarly journals EFFECTS OF MATERNAL EXPOSURE TO DIETHYLSTILBESTROL ON THE DEVELOPMENT OF THE REPRODUCTIVE SYSTEM AND THYROID FUNCTION IN MALE AND FEMALE RAT OFFSPRING

2003 ◽  
Vol 28 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Masako YAMAMOTO ◽  
Mitsuyuki SHIRAI ◽  
Kana SUGITA ◽  
Naoko NAGAI ◽  
Yumi MIURA ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reproductive System ◽  
Maternal Exposure ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring

834 EFFECT OF MATERNAL OBESITY INDUCED BY DIFFERENT DIET PROGRAM ON THE PLASMA LEVELS OF APPETITE HORMONES AND INTESTINAL EXPRESSION OF ADIPOKINES AND ADIPO RECEPTORS 1 AND 2 IN MALE AND FEMALE RAT OFFSPRING

2020 ◽  
Vol 158 (6) ◽  
pp. S-165-S-166
Author(s):  
Urszula Glowacka ◽  
Kinga Gawlinska ◽  
Dawid Gawlinski ◽  
Marcin Magierowski ◽  
Zbigniew Sliwowski ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Maternal Obesity ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring

scholarly journals Developmental Effects of Prenatal Cocaine Exposure on 5-HT1A Receptors in Male and Female Rat Offspring

2002 ◽  
Vol 24 (6) ◽  
pp. 522-530 ◽  
Author(s):  
Josephine M. Johns ◽  
Deborah A. Lubin ◽  
Jeffrey A. Lieberman ◽  
Jean M. Lauder
Keyword(s):  
Female Rat ◽  
Cocaine Exposure ◽  
Prenatal Cocaine Exposure ◽  
Male And Female ◽  
Rat Offspring ◽  
Developmental Effects ◽  
Prenatal Cocaine

Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics

2019 ◽  
Vol 82 (10) ◽  
pp. 603-615 ◽  
Author(s):  
Clément Rosique ◽  
Dalila Lebsir ◽  
Philippe Lestaevel ◽  
Sheherazade Benatia ◽  
Pierre Guigon ◽  
...  
Keyword(s):  
Potassium Iodide ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring ◽  
Repeated Doses

Differential Lung Responses to Early Life Ozone Exposure in Male and Female Rat Offspring

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Janice Dye ◽  
Erica Stewart ◽  
Mette Schladweiler ◽  
Lisa Copeland ◽  
Urmila Kodavanti ◽  
...  
Keyword(s):  
Early Life ◽  
Ozone Exposure ◽  
Female Rat ◽  
Male And Female ◽  
Rat Offspring

scholarly journals Affected skeletal growth but normal bone mineralization in rat offspring after prenatal dexamethasone exposure

2002 ◽  
Vol 174 (3) ◽  
pp. 411-418 ◽  
Author(s):  
D Swolin-Eide ◽  
J Dahlgren ◽  
C Nilsson ◽  
K Albertsson Wikland ◽  
A Holmang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Adult Life ◽  
Skeletal Growth ◽  
Fetal Life ◽  
Female Rat ◽  
Mineral Density ◽  
Crown Rump Length ◽  
Male And Female ◽  
Rat Offspring

Events occurring early in life or prenatally are able to play important roles in the pathogenesis of diseases in adult life. Different sorts of stress or hormonal influences, during particular periods of pregnancy, may result in persisting or transient changes in physiology. Glucocorticoids are used for the treatment of a variety of diseases, to promote organ maturation and to prevent preterm delivery. Glucocorticoids are also known to affect skeletal growth and adult bone metabolism. The aim of the present study was to investigate whether exposure to dexamethasone (Dex) during fetal life has any effect on skeletal growth and/or bone mineral density in adult rat offspring. Pregnant rats were given injections of either Dex (100 micro g/kg) or vehicle on days 9, 11 and 13 of gestation. Dex-exposed male but not female rat offspring showed transient increases in crown-rump length and tibia and femur lengths at 3-6 weeks of age. In contrast, the cortical bone dimensions were altered in 12-week-old female but not male Dex-exposed offspring. The areal bone mineral densities of the long bones and the spine, as determined by dual X-ray absorptiometry, and trabecular as well as cortical volumetric bone mineral density, as measured using peripheral quantitative computerized tomography, were unchanged in both male and female Dex-exposed offspring. In conclusion, prenatal Dex exposure affects skeletal growth in a gender-specific manner, while the mineralization of bones is unaffected in both male and female offspring.

Sign in / Sign up

Export Citation Format

Share Document