OXIDIZED LOW-DENSITY LIPOPROTEINS REDUCE MICRO-RNA 146B EXPRESSION AND LEAD TO ENDOTHELIAL DYSFUNCTION: ROLE OF TRAF6 SIGNALING PATHWAY

2016 ◽  
Vol 32 (10) ◽  
pp. S259
Author(s):  
M. Desjarlais ◽  
S. Dussault ◽  
V. Sanchez ◽  
S. Harel ◽  
S. Hussain ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Signaling Pathway ◽  
Low Density Lipoproteins ◽  
Micro Rna ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins

scholarly journals Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

2013 ◽  
Vol 58 (4) ◽  
pp. 801-810 ◽  
Author(s):  
Sofie M.A. Walenbergh ◽  
Ger H. Koek ◽  
Veerle Bieghs ◽  
Ronit Shiri-Sverdlov
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Alcoholic Steatohepatitis ◽  
Oxidized Low Density Lipoproteins

scholarly journals The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Giuseppe Maiolino ◽  
Giacomo Rossitto ◽  
Paola Caielli ◽  
Valeria Bisogni ◽  
Gian Paolo Rossi ◽  
...  
Keyword(s):  
Experimental Data ◽  
Randomized Clinical Trials ◽  
Low Density Lipoproteins ◽  
Oxidative Modification ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins ◽  
Plaque Development ◽  
Risk Patients ◽  
Tunica Intima

The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low-density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still debated. This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical approaches. Experimental data carried out in cellular lines and animal models of atherosclerosis support the proatherogenic role of oxidized LDLs: (a) through chemotactic and proliferating actions on monocytes/macrophages, inciting their transformation into foam cells; (b) through stimulation of smooth muscle cells (SMCs) recruitment and proliferation in the tunica intima; (c) through eliciting endothelial cells, SMCs, and macrophages apoptosis with ensuing necrotic core development. Moreover, most of the experimental data on atherosclerosis-prone animals benefiting from antioxidant treatment points towards a link between oxidative stress and atherosclerosis. The evidence coming from cohort studies demonstrating an association between oxidized LDLs and cardiovascular events, notwithstanding some discrepancies, seems to point towards a role of oxidized LDLs in atherosclerotic plaque development and destabilization. Finally, the results of randomized clinical trials employing antioxidants completed up to date, despite demonstrating no benefits in healthy populations, suggest a benefit in high-risk patients. In conclusion, available data seem to validate the oxidative modification hypothesis of atherosclerosis, although additional proofs are still needed.

Ramipril Prevents Endothelial Dysfunction Induced by Oxidized Low-Density Lipoproteins

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 371-376 ◽  
Author(s):  
Guy Berkenboom ◽  
Ingrid Langer ◽  
Yvon Carpentier ◽  
Katrina Grosfils ◽  
Jeanine Fontaine
Keyword(s):  
Endothelial Dysfunction ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins

ETIOLOGICAL ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEINS IN THE DEVELOPMENT OF ISCHEMIC STROKE

Pharmateca ◽  
2018 ◽  
Vol 5_2018 ◽  
pp. 8-14
Author(s):  
O.V. Chernichuk () Chernichuk ◽  
O.V. Lyang ( Lyang ◽  
) ) ◽  
A.G. Kochetov ( Kochetov ◽  
) ) ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Etiological Role ◽  
Oxidized Low Density Lipoproteins

scholarly journals Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins

2008 ◽  
Vol 50 (3) ◽  
pp. 364-375 ◽  
Author(s):  
Patricia Martínez-Miguel ◽  
Viviana Raoch ◽  
Carlos Zaragoza ◽  
Jose Manuel Valdivielso ◽  
Manuel Rodríguez-Puyol ◽  
...  
Keyword(s):  
Potential Role ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Converting Enzyme ◽  
Oxidized Low Density Lipoproteins ◽  
Endothelin Converting Enzyme

Atherogenic role of protein-modified oxidized low-density lipoproteins and related autoantibodies

2004 ◽  
Vol 3 (7-8) ◽  
pp. 603-604
Author(s):  
Eiji Matsuura ◽  
Kazuko Kobayashi ◽  
Yehuda Shoenfeld ◽  
Luis R. Lopez
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins
Sign in / Sign up

Export Citation Format

Share Document