Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy

2016 ◽  
Vol 32 (5) ◽  
pp. 680-686.e4 ◽  
Author(s):  
Matthias Barton ◽  
Marc Husmann ◽  
Matthias R. Meyer
Keyword(s):  
Disease Prevention ◽  
Vascular Disease ◽  
Vascular Aging ◽  
Prevention And Therapy

The flavonoid quercetin in disease prevention and therapy: Facts and fancies

2012 ◽  
Vol 83 (1) ◽  
pp. 6-15 ◽  
Author(s):  
Maria Russo ◽  
Carmela Spagnuolo ◽  
Idolo Tedesco ◽  
Stefania Bilotto ◽  
Gian Luigi Russo
Keyword(s):  
Disease Prevention ◽  
Flavonoid Quercetin ◽  
Prevention And Therapy

Subclinical Hypothyroidism and Lipid Abnormalities in Older Women Attending a Vascular Disease Prevention Clinic: Effect of Thyroid Replacement Therapy

Angiology ◽  
2003 ◽  
Vol 54 (5) ◽  
pp. 569-576 ◽  
Author(s):  
Emmanouil S. Ganotakis ◽  
Kiriaki Mandalaki ◽  
Maria Tampakaki ◽  
Niki Malliaraki ◽  
Emmanouil Mandalakis ◽  
...  
Keyword(s):  
Disease Prevention ◽  
Vascular Disease ◽  
Replacement Therapy ◽  
Older Women ◽  
Subclinical Hypothyroidism ◽  
Lipid Abnormalities ◽  
Prevention Clinic

Vascular disease prevention and screening in women

2021 ◽  
pp. 297-306
Author(s):  
Kimberly Zamor ◽  
Sadia Ilyas ◽  
Philip Goodney
Keyword(s):  
Disease Prevention ◽  
Vascular Disease

Abstract T MP114: PPARγ in Endothelial Cells Plays an Essential Role in Protecting Against Vascular Aging: Role of Oxidative Stress and Rho Kinase

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Dale Kinzenbaw ◽  
T. Micheal De Silva ◽  
Curt Sigmund ◽  
Frank M Faraci
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Vascular Disease ◽  
Vascular Dysfunction ◽  
Rho Kinase ◽  
Dominant Negative ◽  
Vascular Aging ◽  
Dominant Negative Mutation ◽  
Age Related

Although aging is the greatest risk factor for vascular disease and stroke, relatively little is known regarding mechanisms that regulate vascular aging. Endothelial dysfunction - a key element of carotid artery and cerebrovascular disease - progresses with age, greatly increasing the risk for ischemic stroke and cognitive impairment. The nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ) is a ligand-activated transcription factor that may exert diverse effects depending on the cell type. Because little is known regarding the role of PPARγ in vascular aging, we used transgenic mice expressing a dominant negative mutation in human PPARγ (V290M) under control of the endothelial-specific vascular cadherin promoter (designated E-V290M) to examine the hypothesis that cell-specific interference with PPARγ would promote age-induced vascular dysfunction. Responses of carotid arteries from adult (11-12 mo) and old (24±1 mo) E-V290M mice and non-transgenic littermates were examined in vitro. Acetylcholine (an endothelium-dependent agonist) produced similar relaxation of arteries from adult control and E-V290M mice as well as old control mice. In contrast, responses to acetylcholine in arteries from old E-V290M mice were reduced by more than 50% in old E-V290M mice (P<0.01). Endothelial function in old E-V290M mice was not altered by indomethacin but was restored to normal by tempol (a superoxide scavenger) or VAS-2870 (an inhibitor of NADPH oxidase). Reactive oxygen species can activate Rho kinase (a potential mediator of vascular disease) and inhibition of Rho kinase with Y-27632 restored endothelial function to normal in old E-V290M mice. Relaxation of arteries to nitroprusside, which acts directly on vascular muscle, was similar in all groups. These findings provide the first evidence that age-related vascular dysfunction is accelerated following cell-specific interference with endothelial PPARγ through mechanisms involving oxidative stress and Rho kinase. This novel role for endothelial PPARγ has implications for understanding vascular pathophysiology as well as therapeutic approaches for age-induced large and small vessel disease.

Sign in / Sign up

Export Citation Format

Share Document