Predictive Value of Neutrophil Gelatinase-Associated Lipocalin for Contrast-Induced Acute Kidney Injury After Cardiac Catheterization: A Meta-analysis

2016 ◽  
Vol 32 (8) ◽  
pp. 1033.e19-1033.e29 ◽  
Author(s):  
Kun Wang ◽  
Chong-yang Duan ◽  
Jun Wu ◽  
Yong Liu ◽  
Wei-jie Bei ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Catheterization ◽  
Predictive Value ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Neutrophil Gelatinase Associated Lipocalin Urin sebagai Deteksi Dini Acute Kidney Injury

Sari Pediatri ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 195
Author(s):  
Siti Aizah Lawang ◽  
Antonius Pudjiadi ◽  
Abdul Latief
Keyword(s):  
Acute Kidney Injury ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Area Under Curve ◽  
Kidney Injury ◽  
Cross Sectional ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Consecutive Sampling ◽  
Neutrophil Gelatinase

Latar belakang. Penelitian terkini fokus pada identifikasi biomarker yang lebih dini untuk acute kidney injury (AKI). Salah satunya adalah neutrophil gelatinase associated lipocalin (NGAL), protein 25 kDa yang merupakan potensial biomarker dini untuk AKI.Tujuan. Melihat neutrophil gelatinase associated lipocalin (NGAL) sebagai biomarker dini untuk acute kidney injury (AKI).Metode. Penelitian kualitatif dengan desain uji diagnostik. Pengambilan sampel secara cross sectional dan consecutive sampling pada 50 orang anak, terdiri atas 28 sepsis dan 22 sepsis berat di ruang rawat intensif anak di RS. Cipto Mangunkusomo Jakarta dan RS. Wahidin Sudirohusodo Makassar.Hasil. Terdapat perbedaan sangat bermakna kadar NGAL urin dan kreatinin berdasarkan beratnya sepsis (p<0,001). Nilai rerata sepsis 132,93 ng/mL dan sepsis berat 2159,98 ng/mL. Terdapat perbedaan bermakna antara beratnya AKI menurut kriteria RIFFLE dengan beratnya sepsis (p=0,013). Tidak terdapat hubungan bermakna antara kadar NGAL urin dengan kriteria RIFFLE (p=0,173). Nilai sensitifitas NGAL urin 100% dan spesifisitas 63,63%, positive predictive value 27,27%, negative predictive value 100% dan area under curve (AuOC) 0,826.Kesimpulan. Neutrophil gelatinase associated lipocalin (NGAL) dapat dipakai sebagai skrining AKI.

scholarly journals The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Qing Li ◽  
Yimin Huang ◽  
Weifeng Shang ◽  
Ying Zhang ◽  
Yanyan Liu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Catheterization ◽  
Predictive Value ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Kidney Injury ◽  
Population Characteristics ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Summary Receiver Operating Characteristic

Background. Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics. However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AKI) remains unclear. Method. Medline, Embase, ClinicalTrials.gov, Cochrane Library database, and the China National Knowledge Infrastructure (CNKI) were used to identify relevant studies from their inception to November 31, 2019. Studies that met the inclusion criteria were included. Relevant data were extracted to obtain pooled sensitivity (SEN) and specificity (SPE), summary receiver operating characteristic curve (ROC), and area under the ROC (AUC or AUROC). A bivariate mixed-effects regression model was used for data analysis. Results. A total of 946 patients from 8 eligible studies were included. Across all the studies, the diagnostic odds ratio (DOR) for uKIM-1 level to predict CI-AKI was 19 (95% CI 10–39), with SEN and SPE of 0.84 and 0.78, respectively. The AUROC for uKIM-1 in predicting CI-AKI was 0.88 (95% CI 0.85–0.90). There was a substantial heterogeneity across the studies (I2 was 37.73% for the summary sensitivity and 69.31% for the summary specificity). Conclusion. Urinary KIM-1 has a high predictive value for diagnosis of CI-AKI in patients who have undergone cardiac catheterization.

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