scholarly journals OPTIMIZATION OF CARDIAC ENERGY METABOLISM BY MALONYL COA DECARBOXYLASE INHIBITOR IMPROVES CARDIAC FUNCTION POST MYOCARDIAL INFARCTION IN RATS

2015 ◽  
Vol 31 (10) ◽  
pp. S303
Author(s):  
W. Wang ◽  
L. Zhang ◽  
C. Wagg ◽  
O.A. Alrob ◽  
N. Fillmore ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Energy Metabolism ◽  
Cardiac Function ◽  
Post Myocardial Infarction ◽  
Decarboxylase Inhibitor ◽  
Malonyl Coa ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency

Metabolism ◽  
2019 ◽  
Vol 98 ◽  
pp. 37-48 ◽  
Author(s):  
Tariq R. Altamimi ◽  
Su Gao ◽  
Qutuba G. Karwi ◽  
Arata Fukushima ◽  
Sonia Rawat ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cardiac Function ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism

2018 ◽  
Vol 475 (5) ◽  
pp. 959-976 ◽  
Author(s):  
Tariq R. Altamimi ◽  
Panakkezhum D. Thomas ◽  
Ahmed M. Darwesh ◽  
Natasha Fillmore ◽  
Mohammad U. Mahmoud ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Glucose Oxidation ◽  
Carnitine Acetyltransferase ◽  
Atp Citrate Lyase ◽  
Acetyl Coa ◽  
Protein Levels ◽  
Citrate Lyase ◽  
Malonyl Coa ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

The role of carnitine acetyltransferase (CrAT) in regulating cardiac energy metabolism is poorly understood. CrAT modulates mitochondrial acetyl-CoA/CoA (coenzyme A) ratios, thus regulating pyruvate dehydrogenase activity and glucose oxidation. Here, we propose that cardiac CrAT also provides cytosolic acetyl-CoA for the production of malonyl-CoA, a potent inhibitor of fatty acid oxidation. We show that in the murine cardiomyocyte cytosol, reverse CrAT activity (RCrAT, producing acetyl-CoA) is higher compared with the liver, which primarily uses ATP-citrate lyase to produce cytosolic acetyl-CoA for lipogenesis. The heart displayed a lower RCrAT Km for CoA compared with the liver. Furthermore, cytosolic RCrAT accounted for 4.6 ± 0.7% of total activity in heart tissue and 12.7 ± 0.2% in H9C2 cells, while highly purified heart cytosolic fractions showed significant CrAT protein levels. To investigate the relationship between CrAT and acetyl-CoA carboxylase (ACC), the cytosolic enzyme catalyzing malonyl-CoA production from acetyl-CoA, we studied ACC2-knockout mouse hearts which showed decreased CrAT protein levels and activity, associated with increased palmitate oxidation and acetyl-CoA/CoA ratio compared with controls. Conversely, feeding mice a high-fat diet for 10 weeks increased cardiac CrAT protein levels and activity, associated with a reduced acetyl-CoA/CoA ratio and glucose oxidation. These data support the presence of a cytosolic CrAT with a low Km for CoA, favoring the formation of cytosolic acetyl-CoA, providing an additional source to the classical ATP-citrate lyase pathway, and that there is an inverse relation between CrAT and the ratio of acetyl-CoA/CoA as evident in conditions affecting the regulation of cardiac energy metabolism.

scholarly journals Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

2019 ◽  
Vol 4 (3) ◽  
pp. 385-400 ◽  
Author(s):  
Wei Wang ◽  
Liyan Zhang ◽  
Pavan K. Battiprolu ◽  
Arata Fukushima ◽  
Khanh Nguyen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Post Myocardial Infarction ◽  
Decarboxylase Inhibition ◽  
Malonyl Coa

PPARα regulates cardiac energy metabolism by controlling malonyl COA concentrations in the heart

2001 ◽  
Vol 33 (6) ◽  
pp. A164
Author(s):  
Fiona M. Campbell ◽  
Ray Kozak ◽  
Alese Wagner ◽  
Judith Y. Altarelos ◽  
Jason R.B. Dyck ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Malonyl Coa ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy
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