scholarly journals PROLONGED TEMPORARY PACING WITH BIPOLAR ACTIVE FIXATION PACEMAKER LEADS: INSIGHTS FROM THE MONTRÉAL HEART INSTITUTE EXPERIENCE

2015 ◽  
Vol 31 (10) ◽  
pp. S260
Author(s):  
M.S. Ascoeta ◽  
B. Casteigt ◽  
J. Palazzolo ◽  
S. Venier ◽  
J. Cadrin-Tourigny ◽  
...  
Author(s):  
Pier Giorgio Golzio ◽  
Arianna Bissolino ◽  
Raffaele Ceci ◽  
Simone Frea

Abstract Background ‘Idiopathic’ lead macrodislodgement may be due to Twiddler’s syndrome depending on active twisting of pulse generator within subcutaneous pocket. All leads are involved, at any time from implantation, and frequently damaged. In the past few years, a reel syndrome was also observed: retraction of pacemaker leads into pocket without patient manipulation, owing to lead circling the generator. In other cases, a ‘ratchet’ mechanism has been postulated. Reel and ratchet mechanisms require loose anchoring, occur generally briefly after implantation, with non-damaged leads. We report the first case of an active-fixation coronary sinus lead selective macrodislodgement involving such ratchet mechanism. Case summary A 65-year-old man underwent biventricular defibrillator device implantation, with active-fixation coronary sinus lead. Eight months later, he complained of muscle contractions over device pocket. At fluoroscopy, coronary sinus lead was found near to pocket, outside of thoracic inlet. Atrial and ventricular leads were in normal position. After opening pocket, a short tract of coronary sinus lead appeared anteriorly dislocated to generator, while greater length of lead body twisted a reel behind. The distal part of lead was found outside venous entry at careful dissection. Atrial and ventricular leads were firmly anchored. Discussion Our case is a selective ‘Idiopathic’ lead macrodislodgement, possibly due to a ratchet mechanism between the lead and the suture sleeve, induced by normal arm motion; such mechanism incredibly, and for first time in literature involves a coronary sinus active-fixation lead. Conclusion Careful attention should always be paid to secure anchoring even of active-fixation coronary sinus leads.


2012 ◽  
Vol 28 (5) ◽  
pp. S128
Author(s):  
C. Chen ◽  
M. Laflamme ◽  
D. Bouchard ◽  
Y. Hébert ◽  
M. Carrier ◽  
...  

Author(s):  
I. Keituqwa Yáñez ◽  
J. Navarro Martínez ◽  
M. García Valiente ◽  
F.J. Rodríguez González ◽  
S. Nicolás Franco

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
David Rhainds ◽  
Low-Kam Cecile ◽  
Boulé Marie ◽  
Alem Sonia ◽  
Mongrain Ian ◽  
...  

Recent clinical trials and Mendelian randomization studies suggest that raising HDL-cholesterol (HDL-C) concentration by itself is insufficient to lower cardiovascular (CV) risk, despite the established inverse relationship between HDL-C and cardiovascular risk. CV protection may derive from other characteristics of HDL. Such characteristics include the cholesterol efflux capacity of serum, the process by which HDL particles accept cholesterol from macrophages and other cell types. Recently, higher cholesterol efflux capacity was inversely associated with incident CV events over a >9 year period of follow-up, with a 67% risk reduction in the highest quartile of efflux. In our study, cholesterol efflux capacity was measured for 2000 patients from the Montreal Heart Institute Biobank as the ratio of pooled control serum. When comparing unadjusted cholesterol efflux values between 1000 controls and 1000 cases with previous myocardial infarction (MI), we observed significant decreases of efflux capacity in cases with J774 macrophages in basal and cAMP-stimulated conditions, with human HepG2 hepatocytes and with BHK cells expressing human ABCA1. In regression models of MI status against efflux variables, also adjusted for age, sex, HDL-C, triglycerides and statin use, the reduction in cholesterol efflux capacity in cases vs. controls remained highly significant for J774 cells in basal (p value = 5.8x10-11) and cAMP-stimulated conditions (p = 5.3x10-8), while the difference was lost with HepG2 cells (p=0.16) and was reversed for ABCA1-dependent efflux using BHK-ABCA1 cells (p=5.9x10-4). Thus, the relationship of cholesterol efflux capacity of serum HDL and cardiovascular status is heterogeneous, which suggest that the repertoire of cholesterol transporters expressed in cells and samples characteristics, such as the HDL proteome and lipidome, interact in a unique manner for each cell type. Future work will consist in identifying sources of such differences at the molecular level.


CJC Open ◽  
2019 ◽  
Vol 1 (5) ◽  
pp. 238-244
Author(s):  
Nadia Boulé-Laghzali ◽  
Laura Dominguez Pérez ◽  
Katia Dyrda ◽  
Jean-François Tanguay ◽  
Malorie Chabot-Blanchet ◽  
...  

EP Europace ◽  
2013 ◽  
Vol 15 (9) ◽  
pp. 1287-1291 ◽  
Author(s):  
H. Kawata ◽  
V. Pretorius ◽  
H. Phan ◽  
S. Mulpuru ◽  
V. Gadiyaram ◽  
...  

2000 ◽  
Vol 23 (11P2) ◽  
pp. 1798-1800 ◽  
Author(s):  
FRANÇOISE HIDDEN-LUCET ◽  
FRANCK HALIMI ◽  
YVES GALLAIS ◽  
JEAN-CLAUDE PETITOT ◽  
GUY FONTAINE ◽  
...  

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