scholarly journals SEX DIFFERENCES IN CLINICAL OUTCOMES AFTER PREMATURE ACUTE CORONARY SYNDROME

2015 ◽  
Vol 31 (10) ◽  
pp. S13
Author(s):  
J. Choi ◽  
N. Winters ◽  
R. Pelletier ◽  
M. Eisenberg ◽  
S. Bacon ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Sex Differences ◽  
Clinical Outcomes ◽  
Coronary Syndrome

Sex Differences in Clinical Outcomes After Premature Acute Coronary Syndrome

2016 ◽  
Vol 32 (12) ◽  
pp. 1447-1453 ◽  
Author(s):  
Roxanne Pelletier ◽  
Jin Choi ◽  
Nicholas Winters ◽  
Mark J. Eisenberg ◽  
Simon L. Bacon ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Sex Differences ◽  
Clinical Outcomes ◽  
Coronary Syndrome

scholarly journals Sex-differences in the management and clinical outcome among patients with acute coronary syndrome

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yunliang Zou ◽  
Wenjian Zhu ◽  
Jing Zeng ◽  
Junyu Lin ◽  
Siping Dai
Keyword(s):  
Emergency Department ◽  
Acute Coronary Syndrome ◽  
Sex Differences ◽  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Symptom Onset ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Coronary Intervention ◽  
Coronary Syndrome

Abstract Background The current study was to compare the management and clinical outcome between women and men with acute coronary syndrome (ACS). Method This was a retrospective study. Patients with ACS presented to the emergency department were enrolled. Management and clinical outcomes (including mortality and acute decompensated heart failure [ADHF]) were compared between women and men. Results A total of 686 patients were included and women accounted for 38.5% (n = 264). Women were less likely to receive ticagrelor at the emergency department (18.2% vs 25.1%). Duration from arrival at the emergency department to undergo electrocardiogram was longer in women (7.5 min vs 5.3 min). The duration from symptom onset to undergo percutaneous coronary intervention was longer in women (14.4 h vs 7.2 h). After adjusting for covariates, odds ratio (OR) for cardiovascular mortality was 0.42 (95% confidence interval [CI] 0.37–1.02) and ADHF was 0.63 (95% CI 0.55–1.01) for women vs men. Socioeconomic status, duration from symptom onset to arrive at the emergency department, and management at the emergency department were the important factors contributing to the sex-differences in clinical outcome. Conclusion Among ACS patients undergoing PCI, there was no sex-difference in in-hospital clinical outcome after adjusting for covariates. Future studies are needed to evaluate whether improving management at the emergency department can improve clinical outcomes in women and men with ACS.

scholarly journals Risk factors and clinical outcomes of acute coronary syndrome in men: A retrospective study

2020 ◽  
Vol 72 ◽  
pp. S5
Author(s):  
Shahood Ajaz Kakroo ◽  
Kala Jeethender Kumar ◽  
O. Sai Satish ◽  
M. Jyotsna ◽  
B. Srinivas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Retrospective Study ◽  
Clinical Outcomes ◽  
Coronary Syndrome

P2245Sex differences in the in-vivo markers of platelet activation among patients with ischemic heart disease: insights from the EVA study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
V Raparelli ◽  
G F Romiti ◽  
N Sperduti ◽  
G F Santangelo ◽  
M Vano ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Sex Differences ◽  
Coronary Artery ◽  
Coronary Stenosis ◽  
Clinical Presentation ◽  
Coronary Syndrome ◽  
Chronic Angina ◽  
Artery Disease

Abstract Background/Introduction Ischemic heart diseases (IHD) are not synonymous with obstructive flow-limiting coronary artery disease (CAD), especially in women. Platelet dysfunction is suggested as a potential mechanism favouring ischemia in non-obstructive CAD. However, it is unknown whether sex differences in platelet function of patients with non-obstructive CAD exist. Purpose We assessed for sex differences in in-vivo markers of platelet activation among patients with the acute coronary syndrome and chronic stable angina, with or without obstructive CAD Methods From the “Endocrine Vascular disease Approach” (EVA) study, we selected IHD patients undergoing urgent or elective coronary angiography with complete baseline clinical characteristics and angiographic data. Non-obstructive CAD was defined as the presence of coronary stenosis <50%. Thromboxane B2 (TxB2) and soluble P-selectin (sP-s) were measured at baseline. A sex-stratified analysis of platelet biomarkers was performed. Results Among two-hundred-seventy-seven patients (mean age 67±11, 37% women), non-obstructive CAD was documented in 25% of patients. Acute coronary syndrome (ACS) was the reason for angiography in 61% of cases. Women had more frequently ACS, as compared with men (54.8% vs 41.3%, p=0.001), with predominantly non-obstructive CAD. Median serum TxB2 (121.5 [92.7–174.0] vs 103.5 [83.0–140.2] pg/ml, p=0.005) and plasma sP-s (27.0 [18.7–35.0] vs 22.0 [16.0–30.0] ng/ml, p=0.006) levels were higher in patients with ACS as compared with the ones with stable chronic angina. The median concentration of TxB2 was significantly increased in women as compared with men, regardless of the clinical presentation and the coronary stenosis degree (all comparison, p<0.001). However, women with non-obstructive CAD were the group with the highest serum levels of TxB2 (140.0 [111.0–152.0] pg/ml). Sex differences in the plasma sP-s level were also observed among patients with stable chronic angina (women, 26 [20.0–34.0] vs men, 21 [16.6–27.7] ng/ml, p=0.002) and with non-obstructive CAD (women, 26 [20.5–34.5] vs men, 18.5 [16.6–26.0] ng/ml, p=0.003). Conclusion(s) Women with IHD and non-obstructive CAD had increased level of TxB2 and sP-s as compared with men, independently by the clinical presentation. Further investigations are warranted to verify the role of platelet hyperactivation in the pathogenesis of myocardial ischemia with non-obstructive coronary artery disease among women. Acknowledgement/Funding Scientific Independence of Young Researchers Program (RBSI14HNVT) - Ministry of Education, University and Research (MIUR)

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