Novel Application of 3-Dimensional Real-Time Cardiac Imaging to Guide Stem Cell-Based Therapy

2015 ◽  
Vol 31 (8) ◽  
pp. 1073.e13-1073.e15 ◽  
Author(s):  
Corrado Carbucicchio ◽  
Michela Casella ◽  
Valentina Catto ◽  
Beatrice Bassetti ◽  
Alberto Bestetti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Real Time ◽  
Cardiac Imaging ◽  
3 Dimensional ◽  
Cell Based Therapy

scholarly journals High-resolution, real-time, and nonfluoroscopic 3-dimensional cardiac imaging and catheter navigation in humans using a novel dielectric-based system

Heart Rhythm ◽  
2019 ◽  
Vol 16 (12) ◽  
pp. 1883-1889 ◽  
Author(s):  
Alexander Romanov ◽  
Eli Dichterman ◽  
Yitzhack Schwartz ◽  
Zalman Ibragimov ◽  
Yehonatan Ben-David ◽  
...  
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Cardiac Imaging ◽  
3 Dimensional ◽  
Catheter Navigation

Real-Time Imaging Tracking of Mesenchymal Stem Cells Labeled with Lipid-Poly(lactic-co-glycolic acid) Nanobubbles

2019 ◽  
Vol 15 (11) ◽  
pp. 2271-2280
Author(s):  
Hongmei Liu ◽  
Sai Liu ◽  
Yangbiao Liang ◽  
Zhiting Deng ◽  
Yu Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Glycolic Acid ◽  
Underlying Mechanism ◽  
Cell Based Therapy ◽  
Wide Range

Stem-cell-based therapy has attracted considerable attention due to the significant benefits to patients experiencing a wide range of diseases and injuries. However, their underlying mechanism of action is not completely understood. One main reason is the lack of imaging tools for real-time tracking of deep-seated transplanted stem cells. For the present study, we exploited a lipid poly(lactic-co-glycolic acid) nanobubble (LPN) probe with nanoscale size, good compatibility, and strong contrast-enhanced ultrasound signals. Due to the nanoscale particle size, cellular labeling of mesenchymal stem cells can be achieved via incubation with LPNs. Significantly enhanced ultrasound images of these labeled stem cells were obtained in vitro and in vivo. More importantly, the labeled stem cells could be tracked by ultrasound imaging for up to 5 days. Additional evaluation found that the in vivo detection limit achieved 2,000 labeled stem cells in the subcutaneous tissues of living mice. Our study presents a strategy to achieve real-time ultrasound imaging tracking, paving the way for an investigation on the underlying mechanism and future clinical application of stem cell therapy.

Real-time 3-dimensional echocardiography – can there be one more dimension?

2007 ◽  
Vol 148 (52) ◽  
pp. 2451-2460 ◽  
Author(s):  
Attila Nemes ◽  
Marcel L. Geleijnse ◽  
Osama I.I. Soliman ◽  
Ashraf M. Anwar ◽  
Johan G. Bosch ◽  
...  
Keyword(s):  
Real Time ◽  
3 Dimensional ◽  
En Face ◽  
Dimensional Echocardiography

A kardiológiai betegek ellátásában a noninvazív vizsgáló módszereknek alapvető jelentőségük van. Elméletileg a szív akkor vizsgálható tökéletesen, ha természetének megfelelően három dimenzióban rögzítjük a szívciklus szerint. A második generációs, immár real-time (vagyis valós idejű) háromdimenziós echokardiográfok elméletileg optimális lehetőséget nyújtanak a cardialis struktúrák háromdimenziós elemzésére. Real-time 3-dimenziós echokardiográfia során pontosan mérhetők a kamrai és pitvari térfogatok, valamint a kamrai izomtömeg. A billentyűk és a congenitalis abnormalitások ‘en-face’ vizsgálhatók. Használhatóságát terheléses protokollok alkalmazása mellett igazolták. A jelen összefoglaló közlemény célja a módszer bemutatása, lehetséges előnyeinek tisztázása a jelenleg még fennálló technológiai korlátok bemutatásával együtt.

Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

2020 ◽  
Vol 20 ◽  
Author(s):  
Christine Ibrahim ◽  
Hanna Semaan ◽  
Marwan El-Sabban ◽  
Fadia Najjar ◽  
Aline Hamade
Keyword(s):  
Stem Cell ◽  
Drug Repositioning ◽  
World Health ◽  
Unknown Etiology ◽  
Cell Based Therapy ◽  
Pathogenic Virus ◽  
Lung Injuries ◽  
Healthcare Crisis ◽  
Health Organization ◽  
Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

An Update on Human Stem Cell-Based Therapy in Parkinson';s Disease

2016 ◽  
Vol 11 (7) ◽  
pp. 561-568 ◽  
Author(s):  
Clara González ◽  
Sonia Bonilla ◽  
Ana Isabel Flores ◽  
Eva Cano ◽  
Isabel Liste
Keyword(s):  
Stem Cell ◽  
Human Stem Cell ◽  
Cell Based Therapy
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