HIGH-SENSITIVITY CARDIAC TROPONIN T DETECTIONS AND FLUCTUATIONS OVER A YEAR IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: IS THE CLINICAL HISTORY IMPORTANT?

2014 ◽  
Vol 30 (10) ◽  
pp. S339
Author(s):  
D. Garcia-Labbé ◽  
G.R. Dagenais ◽  
S. Simard ◽  
A. LeBlanc ◽  
L. Boyer ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Stable Coronary Artery Disease ◽  
High Sensitivity ◽  
Clinical History ◽  
Cardiac Troponin T ◽  
Artery Disease

scholarly journals Current Smoking Is Associated With Lower Concentrations of High-Sensitivity Cardiac Troponin T in Patients With Stable Coronary Artery Disease

Circulation ◽  
2019 ◽  
Vol 140 (24) ◽  
pp. 2044-2046
Author(s):  
Julia B. Skranes ◽  
Brian L. Claggett ◽  
Peder L. Myhre ◽  
Magnus N. Lyngbakken ◽  
Scott D. Solomon ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Stable Coronary Artery Disease ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Current Smoking ◽  
Artery Disease

scholarly journals A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease

2009 ◽  
Vol 361 (26) ◽  
pp. 2538-2547 ◽  
Author(s):  
Torbjørn Omland ◽  
James A. de Lemos ◽  
Marc S. Sabatine ◽  
Costas A. Christophi ◽  
Madeline Murguia Rice ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Stable Coronary Artery Disease ◽  
Cardiac Troponin T ◽  
Artery Disease

scholarly journals Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease

2018 ◽  
Vol 64 (11) ◽  
pp. 1596-1606 ◽  
Author(s):  
Deborah Mueller ◽  
Christian Puelacher ◽  
Ursina Honegger ◽  
Joan E Walter ◽  
Patrick Badertscher ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diagnostic Accuracy ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Emission Computed Tomography ◽  
Cardiac Troponin T ◽  
Artery Disease

Abstract BACKGROUND We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD). METHODS Consecutive patients referred with clinical suspicion of fCAD and no structural heart disease other than coronary artery disease were included. The presence of fCAD was based on rest/stress myocardial perfusion single-photon emission computed tomography/computed tomography and coronary angiography. hs-cTnI and hs-cTnT concentrations were measured in a blinded fashion. Diagnostic accuracy was quantified using the area under the ROC curve (AUC) and evaluated both for uniform use in all patients and for sex-specific use in women and men separately. The prognostic end point was major adverse cardiac events (MACEs; cardiovascular death or myocardial infarction) within 2 years. For the prognostic performance, we used a multivariable model comparison with the Akaike information criterion (AIC). RESULTS fCAD was detected in 613 of 2062 patients (29.7%) overall, 112 of 664 of women (16.9%), and 501 of 1398 of men (35.8%). hs-cTnI and hs-cTnT had comparable diagnostic accuracy when assessed for uniform use in all patients (AUC, 0.68 vs 0.66; P = 0.107) and separately in women (AUC, 0.68 vs 0.63; P = 0.068) and men (AUC, 0.65 vs 0.64; P = 0.475). However, women required lower rule-out cutoffs to achieve high sensitivity, and men needed higher rule-in cutoffs to achieve high specificity. hs-cTnI and hs-cTnT were strongly and independently associated with MACE within 2 years (P < 0.001), with comparable prognostic accuracies by the AIC. CONCLUSIONS hs-cTnI and hs-cTnT provide moderate and comparable diagnostic accuracy. Sex-specific cutoffs may be preferred. The prognostic utility of both troponins is comparable.

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