167 Elevated Plasma Serotonin and Endothelin-1 in Coronary Artery Disease Patients: A Potential for Novel Pharmacotherapeutic Targets?

2012 ◽  
Vol 28 (5) ◽  
pp. S152-S153
Author(s):  
S. Shousha ◽  
J.G. Diodati ◽  
E. Schampaert ◽  
C. Pharand
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elevated Plasma ◽  
Endothelin 1 ◽  
Artery Disease ◽  
Plasma Serotonin

Dynamic Exercise Induces Elevation of Plasma Levels of Endothelin-1 in Patients with Coronary Artery Disease

Angiology ◽  
1995 ◽  
Vol 46 (9) ◽  
pp. 819-826 ◽  
Author(s):  
C. Letizia ◽  
F. Barillà ◽  
S. Cerci ◽  
C. D'Ambrosio ◽  
S. Coassin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Levels ◽  
Dynamic Exercise ◽  
Endothelin 1 ◽  
Artery Disease

scholarly journals Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Li-li Liang ◽  
Lin Chen ◽  
Meng-yuan Zhou ◽  
Meng-yun Cai ◽  
Jie Cheng ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Endothelin 1 ◽  
Increased Risk ◽  
Artery Disease ◽  
Cad Risk

Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis. Nonetheless, the role of ET-1 (EDN1) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (single-nucleotide polymorphisms) (rs6458155, rs4145451, rs9369217, rs3087459, and rs2070699) within EDN1 gene in 525 CAD patients and 675 control subjects. In a multivariate logistic regression analysis, we detected an association of rs6458155 in EDN1 gene with the CAD risk; compared with the TT homozygotes, the CT heterozygotes (odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.02–2.29, P=0.040) and the CC homozygotes (OR = 1.55, 95% CI = 1.01–2.36, P=0.043) were statistically significantly associated with the increased risk for CAD. A similar trend of the association was found in dominant model (OR = 1.53, 95% CI = 1.05–2.25, P=0.029). Consistently, the haplotype rs6458155C-rs4145451C containing rs6458155 C allele exhibited the increased CAD risk (OR = 1.22, 95% CI = 1.03–1.43, and P=0.018). In addition, CT genotype of rs6458155 conferred the increased plasma ET-1 levels compared with TT genotype (P<0.05). No association of the other four tagSNPs in EDN1 gene with CAD risk was observed. In conclusion, our study provides the first evidence that EDN1 tagSNP rs6458155 is associated with CAD risk in the Chinese Han population, which is probably due to the influence of the circulating ET-1 levels.

scholarly journals Plasma Big Endothelin-1 Level and the Severity of New-onset Stable Coronary Artery Disease

2015 ◽  
Vol 22 (2) ◽  
pp. 126-135 ◽  
Author(s):  
Juan Chen ◽  
Man-Hua Chen ◽  
Yuan-Lin Guo ◽  
Cheng-Gang Zhu ◽  
Rui-Xia Xu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Endothelin 1 ◽  
Artery Disease ◽  
New Onset

Elevated plasma lipid hydroperoxides in patients with coronary artery disease

1997 ◽  
Vol 134 (3) ◽  
pp. 572-576 ◽  
Author(s):  
Iren B. Kovacs ◽  
Marjan Jahangiri ◽  
Gareth M. Rees ◽  
Peter Görög
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Lipid ◽  
Lipid Hydroperoxides ◽  
Elevated Plasma ◽  
Artery Disease

Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease

2009 ◽  
Vol 91 (6) ◽  
pp. 2545-2550 ◽  
Author(s):  
Mesut Oktem ◽  
Emel Ebru Ozcimen ◽  
Ayla Uckuyu ◽  
Ibrahim Esinler ◽  
Baris Pamuk ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cd40 Ligand ◽  
Elevated Plasma ◽  
Ovary Syndrome ◽  
Soluble Cd40 Ligand ◽  
Artery Disease

Endothelin-1 peptide expression in transplant coronary artery disease

1997 ◽  
Vol 29 (6) ◽  
pp. 2577-2578 ◽  
Author(s):  
S. Ravalli ◽  
M. Szabolcs ◽  
A. Albala ◽  
R.E. Michler ◽  
P.J. Cannon
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelin 1 ◽  
Peptide Expression ◽  
Artery Disease

Relation of Elevated Plasma Renin Activity at Baseline to Cardiac Events in Patients With Angiographically Proven Coronary Artery Disease

2010 ◽  
Vol 106 (6) ◽  
pp. 764-769 ◽  
Author(s):  
Joseph B. Muhlestein ◽  
Heidi T. May ◽  
Tami L. Bair ◽  
Margaret F. Prescott ◽  
Benjamin D. Horne ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Elevated Plasma ◽  
Cardiac Events ◽  
Artery Disease
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