111 Pre-operative, intra-operative and post-operative factors associated with heparin induced thrombocytopenia post cardiac surgery

2011 ◽  
Vol 27 (5) ◽  
pp. S103
Author(s):  
R.A. Manji ◽  
T.E. Warkentin ◽  
H.P. Grocott ◽  
A.H. Menkis ◽  
E. Jacobsohn
Keyword(s):  
Cardiac Surgery ◽  
Heparin Induced Thrombocytopenia ◽  
Factors Associated ◽  
Post Cardiac Surgery

The serological profile of early-onset and persisting post-cardiac surgery thrombocytopenia complicated by “true” heparin-induced thrombocytopenia

2012 ◽  
Vol 107 (05) ◽  
pp. 998-1000 ◽  
Author(s):  
Jane C. Moore ◽  
Susan Vogel ◽  
Jo-Ann I. Sheppard ◽  
Nathan I. Warkentin ◽  
John W. Eikelboom ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Early Onset ◽  
Heparin Induced Thrombocytopenia ◽  
Serological Profile ◽  
Post Cardiac Surgery

scholarly journals HEPARIN-INDUCED THROMBOCYTOPENIA TYPE II AMONG SUSPECTED CASES POST-CARDIAC SURGERY

2016 ◽  
Vol 67 (13) ◽  
pp. 210
Author(s):  
Abdulrazak Sheikh Aljazairy ◽  
Reem Bahmaid ◽  
Nathem Akhras ◽  
Tarek Owaidah ◽  
Elias Saad ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Type Ii ◽  
Heparin Induced Thrombocytopenia ◽  
Post Cardiac Surgery

Neutrophil and Monocyte Counts in Heparin-Induced Thrombocytopenia

2019 ◽  
Vol 119 (06) ◽  
pp. 941-951 ◽  
Author(s):  
Madeleine Hui ◽  
Jo-Ann I. Sheppard ◽  
Na Li ◽  
Theodore E. Warkentin
Keyword(s):  
Cardiac Surgery ◽  
Blood Cell ◽  
White Blood Cell ◽  
Monocyte Count ◽  
Heparin Induced Thrombocytopenia ◽  
Post Surgery ◽  
Leukocyte Counts ◽  
Wbc Count ◽  
Diagnosis Of Infection ◽  
Post Cardiac Surgery

Background Heparin-induced thrombocytopenia (HIT) antibodies activate platelets, monocytes and neutrophils. Despite these findings, it is unknown whether white blood cell (WBC) counts, including neutrophils and monocytes, are altered during HIT. Materials and Methods We evaluated changes in total WBC counts (including WBC subsets), in 50 post-cardiac surgery patients with serologically confirmed HIT (30 patients with HIT-associated thrombosis). Daily leukocyte counts were compared with those measured one day prior to HIT onset; WBC increases were classified as mild (20.0–49.9%), moderate (50.0–99.9%) or major (≥ 100% increase). We also compared changes in WBC counts in HIT patients with and without HIT-associated thrombosis, and non-HIT patients with thrombosis. Results Most (34/50 [68.0%]) patients with HIT developed WBC count increases (mild, 35.3%; moderate, 44.1%; major, 20.6%). The peak WBC count occurred on day 4 (median) of HIT, which corresponded to day 10 (median) post-surgery. Absolute neutrophil counts increased in most patients (38/50 [76.0%]); whereas absolute monocyte counts rose in some patients, the overall tendency was for the monocyte count to decrease during HIT. Unexpectedly, we found that the increase in total WBC counts, as well as in neutrophils, was seen mainly in patients who developed HIT-associated or non-HIT-associated thrombosis; in contrast, no difference in monocyte levels was seen in patients with or without thrombosis. Conclusion Leukocytosis and neutrophilia are commonly observed in patients with HIT, particularly in patients with HIT-associated thrombosis, as well as non-HIT patients with thrombosis. Thus, leukocytosis/neutrophilia should not infer automatically a diagnosis of infection or inflammation, when evaluating thrombocytopenia in heparin-exposed patients.

Analysis of Nosocomial Infections in Post–Cardiac Surgery Extracorporeal Membrane Oxygenation Support Therapy

2018 ◽  
Vol 21 (5) ◽  
pp. E387-E391 ◽  
Author(s):  
Binfei Li ◽  
Geqin Sun ◽  
Zhou Cheng ◽  
Chuangchuang Mei ◽  
Xiaozu Liao ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cardiac Surgery ◽  
Extracorporeal Membrane Oxygenation ◽  
Hospital Stay ◽  
Nosocomial Infections ◽  
Total Hospital ◽  
Secondary Infections ◽  
Total Hospital Stay ◽  
Mechanical Ventilation Time ◽  
Post Cardiac Surgery

Objectives: This study aims to analyze the nosocomial infection factors in post–cardiac surgery extracorporeal membrane oxygenation (ECMO) supportive treatment (pCS-ECMO). Methods: The clinical data of the pCS-ECMO patients who obtained nosocomial infections (NI) were collected and analyzed retrospectively. Among the 74 pCS-ECMO patients, 30 occurred with NI, accounting for 40.5%; a total of 38 pathogens were isolated, including 22 strains of Gram-negative bacteria (57.9%), 15 strains of Gram-positive bacteria (39.5%), and 1 fungus (2.6%). Results: Multidrug-resistant strains were highly concentrated, among which Acinetobacter baumannii and various coagulase-negative staphylococci were the main types; NI was related to mechanical ventilation time, intensive care unit (ICU) residence, ECMO duration, and total hospital stay, and the differences were statistically significant (P < .05). The binary logistic regression analysis indicated that ECMO duration was a potential independent risk factor (OR = 0.992, P = .045, 95.0% CI = 0.984-1.000). Conclusions: There existed significant correlations between the secondary infections of pCS-ECMO and mechanical ventilation time, ICU residence, ECMO duration, and total hospital stay; therefore, hospitals should prepare appropriate preventive measures to reduce the incidence of ECMO secondary infections.

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