028 Aortic wall stress in patients with hypertension and ascending aortic aneurysms

2011 ◽  
Vol 27 (5) ◽  
pp. S71-S72
Author(s):  
S.W. Rabkin ◽  
M.T. Janusz
Keyword(s):  
Aortic Wall ◽  
Wall Stress ◽  
Aortic Aneurysms

scholarly journals WALL STRESS IN ASCENDING AORTA ANEURYSMS AS A PREDICTIVE FACTOR OF BREAKAGE

2021 ◽  
Vol 108 (Supplement_3) ◽  
Author(s):  
R J Burgos Lázaro ◽  
N Burgos Frías ◽  
S Serrano-Fiz García ◽  
V Ospina Mosquera ◽  
F Rojo Pérez ◽  
...  
Keyword(s):  
Aortic Wall ◽  
Wall Stress ◽  
Middle Layer ◽  
Ascending Aorta ◽  
Aortic Aneurysms ◽  
Maximum Diameter ◽  
Resistance Factors ◽  
Risk Of Rupture ◽  
Traction Test

Abstract INTRODUCTION The surgical indication for ascending aortic aneurysms (AAA) is established when the maximum diameter > 50 mm; It responds to Laplace's Law (T wall = P × r / 2e). The aim of the study is to define wall stress in AAA. MATERIAL AND METHODS 218 ascending aortic walls have been studied: 96 from organ donors, and 122 from AAA: Marfán 58 (47.5%), bicuspid aortic valve 26 (21.4%), and atherosclerosis 38 (31.1%). The samples were studied "in vitro", according to the model Young's (relationship between stress and deformed area), by means of the mechanical traction test (Tension = Force / Area). The analysis was performed with the stress-elongation curve (d Tension / d Elongation). RESULTS The stress of the aortic wall, classified from highest to lowest according to pathology and age was: cystic necrosis of the middle layer, arteriosclerosis, age > 60 years, between 35 and 59, and < 34 years. The stress of “control aortas” wall increased directly in relation to the age of the donors. CONCLUSIONS The maximum diameter of the ascending aorta, the patient's type of pathology and age are factors that affect the maximum tension of the aortic wall and resistance, factors that allow differentiation and prediction of the risk of rupture of the AAA. The validation of the results obtained through numerical simulation was significant and the uniaxial analysis has modeled the response of the vessels to their internal pressure.

A COMPUTATIONAL MODEL OF BLOOD FLOW AND AORTIC WALL STRESS IN ABDOMINAL AORTIC ANEURYSMS

ASAIO Journal ◽  
1999 ◽  
Vol 45 (2) ◽  
pp. 197
Author(s):  
P J Cabrales ◽  
J E Gómez ◽  
J Camacho ◽  
C Espinel ◽  
J C Briceño
Keyword(s):  
Blood Flow ◽  
Computational Model ◽  
Aortic Wall ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic

Abstract 107: Increased Peak Wall Stress in Women With Abdominal Aortic Aneurysms

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Eric Shang ◽  
Grace Wang ◽  
Ronald Fairman ◽  
Benjamin Jackson
Keyword(s):  
Wall Thickness ◽  
Aortic Wall ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Rupture Risk ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
Aortic Wall Thickness ◽  
Peak Wall Stress

Objective: Women with abdominal aortic aneurysms (AAA) exhibit more rapid aneurysm growth and greater rupture risk at equivalent diameters relative to men. Evidence suggests that biomechanical peak wall stress (PWS) derived from finite element analysis of AAAs is a superior predictor of rupture compared to maximum transverse diameter (MTD). This study aimed to investigate differences in the calculated PWS of AAAs between men and women. Method: Men (n=35) and women (n=35) with infrarenal AAAs with 45-55mm MTD undergoing CTA were identified. Customized image processing algorithms extracted patient-specific AAA geometries from raw DICOM images. The resulting aortic reconstructions incorporated patient-specific and regionally resolved aortic wall thickness, intraluminal thrombus, and wall calcifications. Aortic models were loaded with 120mmHg blood pressure using commercially available FEA solvers. Results: Peak wall stress was found to be significantly higher in women (299±51 vs 257±53 kPA, P=0.001, see Figure). Neither MTD (50.5±3.1 vs 49.8±2.9 mm, P=0.34), mean aortic wall thickness (2.38±0.52 vs 2.34±0.50 mm, P=0.69), nor wall thickness at location of PWS (2.36±0.60 vs 2.20±0.46 mm, P=0.20) varied by sex. While there were no sex-associated differences in aneurysm volume (86.6±27.0 vs 94.8±25.5 cm 3 , P=0.76) or intraluminal thrombus volume (14.2±11.7 vs 16.3±13.4 mm, P=0.33), women’s AAAs had significantly increased maximum Gaussian curvature (0.032±0.011 vs 0.025±0.015 mm -2 , P=0.03). Conclusion: Comparably sized AAAs in women were shown to have significantly higher peak wall stress. Maximum gaussian curvature, a measure of aneurysm morphology, was significantly different between the two groups. These results suggest that men and women possess distinct aneurysm geometries, and that PWS-derived rupture risk prediction may provide a more reliable estimator of rupture risk in all patients.

Inflammation in abdominal aortic aneurysms: cellular infiltrate and cytokine profiles

Vascular ◽  
2012 ◽  
Vol 20 (5) ◽  
pp. 278-283 ◽  
Author(s):  
Matthew J Eagleton
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Wall ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Aneurysm Formation ◽  
Abdominal Aortic ◽  
Genetic Abnormalities ◽  
Cytokine Milieu ◽  
Ultimate Fate ◽  
Pathologic Processes

Abdominal aortic aneurysm (AAA) pathogenesis occurs as a result of the altered homeostasis of the aortic vessel wall structural proteins. This results in weakening, and subsequent expansion, of the aorta leading to aneurysm formation. Multiple mechanisms are involved in this process, including genetic abnormalities, biomechanical wall stress, apoptosis, and proteolytic degradation of the aortic wall. One key hallmark of this pathology, which orchestrates the interaction of the various pathologic processes, is inflammation. The inflammatory process is characterized by the infiltration of a variety of cells, which leads to the upregulation of multiple cytokines. The balance of the cellular type and resultant cytokine milieu determines the ultimate fate of the aortic wall – healing, atherosclerosis or aneurysm formation. This review highlights some of the known cellular and cytokine inflammatory events that are involved in aortic aneurysm formation.

Image-based biomechanical modeling of aortic wall stress and vessel deformation: response to pulsatile arterial pressure simulations

2008 ◽  
Author(s):  
Dilana Hazer ◽  
Miriam Bauer ◽  
Roland Unterhinninghofen ◽  
Rüdiger Dillmann ◽  
Götz-M. Richter
Keyword(s):  
Arterial Pressure ◽  
Aortic Wall ◽  
Wall Stress ◽  
Biomechanical Modeling ◽  
Deformation Response
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