Gold nanoparticle-based inductively coupled plasma mass spectrometry amplification and magnetic separation for the sensitive detection of a virus-specific RNA sequence

2011 ◽  
Vol 1218 (14) ◽  
pp. 1795-1801 ◽  
Author(s):  
I-Hsiang Hsu ◽  
Wen-Hung Chen ◽  
Tung-Kung Wu ◽  
Yuh-Chang Sun
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Magnetic Separation ◽  
Inductively Coupled Plasma ◽  
Sensitive Detection ◽  
Rna Sequence ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Joint forces of direct, single particle, CE– and HPLC–inductively coupled plasma mass spectrometry techniques for the examination of gold nanoparticle accumulation, distribution and changes inside human cells

Metallomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 408-415 ◽  
Author(s):  
Joanna Kruszewska ◽  
Dominika Kulpińska ◽  
Ilona Grabowska-Jadach ◽  
Magdalena Matczuk
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Human Cells ◽  
Inductively Coupled ◽  
Joint Forces ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

ICP-MS-based platform for the characterization of medicinally attractive nanomaterials processing inside human cells.

Application of inductively coupled plasma mass spectrometry in the study of apoptosis: determination of caspase-3 using a gold nanoparticle tag

The Analyst ◽  
2016 ◽  
Vol 141 (3) ◽  
pp. 926-933 ◽  
Author(s):  
Zhengru Liu ◽  
Beibei Chen ◽  
Man He ◽  
Xing Zhang ◽  
Han Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Inductively Coupled Plasma ◽  
Caspase 3 ◽  
Signal Enhancement ◽  
Secondary Antibody ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A simple, fast and sensitive immunoassay for caspase-3 is established by using inductively coupled plasma mass spectrometry (ICP-MS) detection and signal enhancement gold nanoparticle (Au-NP) labelling of the secondary antibody (IgG).

Graphene/gold nanoparticle composites for ultrasensitive and versatile biomarker assay using single-particle inductively-coupled plasma/mass spectrometry

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 7932-7940
Author(s):  
Yuqian Xing ◽  
Juan Han ◽  
Xu Wu ◽  
David T. Pierce ◽  
Julia Xiaojun Zhao
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Nanoparticle Composites

An ultrasensitive biomarker assay platform established by monitoring the gold nanoparticles (AuNPs) desorbed away from graphene triggered by the target using single-particle inductively-coupled plasma/mass spectrometry (spICP-MS).

scholarly journals Sensitive Immunoassay Detection of Plasmodium Lactate Dehydrogenase by Inductively Coupled Plasma Mass Spectrometry

2021 ◽  
Vol 10 ◽  
Author(s):  
Jianbing Mu ◽  
Lee L. Yu ◽  
Thomas E. Wellems
Keyword(s):  
Mass Spectrometry ◽  
Lactate Dehydrogenase ◽  
Inductively Coupled Plasma ◽  
Sensitive Detection ◽  
Sensor Technology ◽  
Inductively Coupled ◽  
Ms Detection ◽  
Icp Ms ◽  
Highly Sensitive ◽  
Plasma Mass Spectrometry

Rapid, reliable, and sensitive detection of Plasmodium infection is central to malaria control and elimination. Many Malaria Rapid Diagnostic Tests (RDTs) developed for this purpose depend upon immunoassays that can be improved by advances in bound antibody sensor technology. In a previous study, immuno-polymerase chain reaction (PCR) was shown to provide highly sensitive detection of Plasmodium falciparum lactate dehydrogenase (PfLDH) in monoclonal antibody (mAb) sandwich assays. Here, we show comparably high immunoassay sensitivity by inductively coupled plasma mass spectrometry (ICP-MS) detection of gold nanoparticles (AuNPs). Following capture of PfLDH with the primary mAb and binding of the AuNP-labeled detection mAb, ICP-MS signals from the AuNPs provided quantitative measures of recombinant PfLDH test dilutions and P. falciparum-infected erythrocytes. A detection limit of 1.5 pg/mL was achieved with the PfLDH protein. Parasitemia in cultures of P. falciparum-infected erythrocytes could be detected to a lower limit of 1.6 parasite/μl (p/μl) for early ring-stage forms and 0.3 p/μl for mixed stages including mature trophozoites and schizont-stages. These results show that ICP-MS detection of AuNPs can support highly sensitive and accurate detection of Plasmodium infection.

scholarly journals Quantitative imaging of 2 nm monolayer-protected gold nanoparticle distributions in tissues using laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS)

The Analyst ◽  
2016 ◽  
Vol 141 (8) ◽  
pp. 2418-2425 ◽  
Author(s):  
S. Gokhan Elci ◽  
Bo Yan ◽  
Sung Tae Kim ◽  
Krishnendu Saha ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Surface Chemistry ◽  
Gold Nanoparticle ◽  
Inductively Coupled Plasma ◽  
Quantitative Imaging ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Imaging reveals that AuNPs remain intact and their surface chemistry influences how they interact with different organs.

Detection ofEscherichia coliO157:H7 Using Gold Nanoparticle Labeling and Inductively Coupled Plasma Mass Spectrometry

2010 ◽  
Vol 82 (8) ◽  
pp. 3399-3403 ◽  
Author(s):  
Feng Li ◽  
Qiang Zhao ◽  
Chuan Wang ◽  
Xiufen Lu ◽  
Xing-Fang Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Studying Gold Nanoparticle Degradation during Laser Ablation - Single Particle - Inductively Coupled Plasma Mass Spectrometry Analysis

2021 ◽  
Author(s):  
Dino Metarapi ◽  
Johannes T. van Elteren ◽  
Martin Šala
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Gold Nanoparticle ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Analysis ◽  
Spectrometry Analysis ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Nanoparticle (NP) analysis performed by laser ablation - single particle - inductively coupled plasma mass spectrometry (LA-sp-ICPMS) has recently allowed for multimodal insights to be gained about NPs in biological...

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