Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography–electrospray ionization tandem mass spectrometry

2011 ◽  
Vol 1218 (10) ◽  
pp. 1367-1378 ◽  
Author(s):  
Shan Liu ◽  
Guang-Guo Ying ◽  
Jian-Liang Zhao ◽  
Feng Chen ◽  
Bin Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Surface Water ◽  
Tandem Mass Spectrometry ◽  
Electrospray Ionization ◽  
Trace Analysis ◽  
Tandem Mass ◽  
Rapid Resolution ◽  
Ionization Tandem Mass Spectrometry

scholarly journals Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Lei Zhang ◽  
Xian Long Cheng ◽  
Yang Liu ◽  
Miao Liang ◽  
Honghuan Dong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Electrospray Ionization ◽  
Tandem Mass ◽  
Exact Mass ◽  
Rapid Resolution ◽  
Chemical Structures ◽  
Related Substances ◽  
Ionization Tandem Mass Spectrometry

Rapid Resolution Liquid Chromatography coupled with Electrospray Ionization Tandem Mass Spectrometry (RRLC-ESI-MSn) was used to separate and identify related substances in ampicillin capsule. The fragmentation behaviors of related substances were used to identify their chemical structures. Finally, a total of 13 related substances in ampicillin capsule were identified, including four identified components for the first time and three groups of isomers on the basis of the exact mass, fragmentation behaviors, retention time, and chemical structures in the literature. This study avoided time-consuming and complex chemosynthesis of related substances of ampicillin and the results could be useful for the quality control of ampicillin capsule to guarantee its safety in clinic. In the meantime, it provided a good example for the rapid identification of chemical structures of related substances of drugs.

Sign in / Sign up

Export Citation Format

Share Document