Comparison of a non-aqueous capillary electrophoresis method with high performance liquid chromatography for the determination of herbicides and metabolites in water samples

2006 ◽  
Vol 1122 (1-2) ◽  
pp. 194-201 ◽  
Author(s):  
R. Carabias-Martínez ◽  
E. Rodríguez-Gonzalo ◽  
E. Miranda-Cruz ◽  
J. Domínguez-Álvarez ◽  
J. Hernández-Méndez
Keyword(s):  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Water Samples ◽  
High Performance ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

Establishing Tablet Dissolution Curve Through Determination of Underivatized Alendronate Sodium by Capillary Electrophoresis-UV Detector

2020 ◽  
Vol 16 (5) ◽  
pp. 615-622
Author(s):  
Tian Luo ◽  
Shujuan He ◽  
Yueting Deng ◽  
Ximin Zhang ◽  
Yuming Dong
Keyword(s):  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
High Performance ◽  
Direct Determination ◽  
Dissolution Profile ◽  
Alendronate Sodium ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

Background: Alendronate sodium is a common clinical osteoporosis drug for postmenopausal women; its determination is very important. However, there is no absorption of chromophores or fluorophores in the molecule, therefore, their direct determination is a challenge. Thus, establishing a common and direct method is very inspiring. Methods: According to the direct determination of alendronate sodium through the formation of a complex between alendronate sodium and divalent copper ion by capillary electrophoresis with ultraviolet detection, the dissolution profile of alendronate sodium tablet was established. The dissolution curves obtained from high-performance liquid chromatography method involving derivatization with 9- fluorenyl methylchloroformate and capillary electrophoresis with ultraviolet detector were found to be highly similar. Underivatized alendronate sodium can be determined by the capillary electrophoresis method. Results: Optimum conditions were as follows: background electrolyte including 25 mM CuSO4 at pH 4.59, 5 s injection time, 18 kV applied voltage, and 240 nm detected wavelength. Method validation indicated good linearity (r2>0.9993), precision of migration time with a relative standard deviation <1.5 % for intra-day and <3.6 % for inter-day, precision of peak areas <2.3 % for intra-day and <5.0 % for inter-day, limits of detection (0.01 μg/mL), limit of quantification (0.04 μg/mL) and recovery (90.6 %- 109.0 %). Conclusion: The proposed capillary electrophoresis method has been proved to be simpler, faster and more convenient to test dissolution profile of alendronate sodium tablet than that of high performance liquid chromatography.

Stability-indicating methods for the enantioselective determination of dihydropyridines by high performance liquid chromatography and capillary electrophoresis

2012 ◽  
Vol 4 (9) ◽  
pp. 2953 ◽  
Author(s):  
Alyne Fávero Galvão ◽  
Tatiana Okura Ajimura ◽  
Fernando Armani Aguiar ◽  
Keyller Bastos Borges ◽  
Cristiane Masetto de Gaitani
Keyword(s):  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
High Performance ◽  
Stability Indicating
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