scholarly journals Malaria Parasites Co-opt Human Factor H to Prevent Complement-Mediated Lysis in the Mosquito Midgut

2013 ◽  
Vol 13 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Nina Simon ◽  
Edwin Lasonder ◽  
Matthias Scheuermayer ◽  
Andrea Kuehn ◽  
Sabrina Tews ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Malaria Parasites ◽  
Mosquito Midgut

scholarly journals The Human Factor H-related Protein 4 (FHR-4)

1997 ◽  
Vol 272 (9) ◽  
pp. 5627-5634 ◽  
Author(s):  
Christine Skerka ◽  
Jens Hellwage ◽  
Wilfried Weber ◽  
Anne Tilkorn ◽  
Friedrich Buck ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Related Protein

Production of biologically active recombinant human factor H in Physcomitrella

2010 ◽  
Vol 9 (3) ◽  
pp. 373-383 ◽  
Author(s):  
Annette Büttner-Mainik ◽  
Juliana Parsons ◽  
Hanna Jérôme ◽  
Andrea Hartmann ◽  
Stephanie Lamer ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Biologically Active

scholarly journals 4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp

2020 ◽  
Vol 16 (10) ◽  
pp. e1008882
Author(s):  
Daniele Veggi ◽  
Federica Bianchi ◽  
Laura Santini ◽  
Paola Lo Surdo ◽  
Chelsy C. Chesterman ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Human Antibodies ◽  
4Cmenb Vaccine

Genetic Polymorphism of Human Factor H (β1H Globulin)

1990 ◽  
Vol 40 (3) ◽  
pp. 121-126 ◽  
Author(s):  
S. Nakamura ◽  
O. Ohue ◽  
A. Sawaguchi
Keyword(s):  
Genetic Polymorphism ◽  
Human Factor ◽  
Factor H

Functional properties of the allotypes of mouse complement regulatory protein, factor H: Difference of compatibility of each allotype with human factor I

1993 ◽  
Vol 30 (9) ◽  
pp. 841-848 ◽  
Author(s):  
Okada Michiyo ◽  
Kojima Ayako ◽  
Takano Hiromi ◽  
Harada Yoshinobu ◽  
Nonaka Mayumi ◽  
...  
Keyword(s):  
Functional Properties ◽  
Human Factor ◽  
Regulatory Protein ◽  
Factor H ◽  
Complement Regulatory Protein ◽  
Factor I ◽  
Protein Factor

scholarly journals Streptococcal β Protein Has Separate Binding Sites for Human Factor H and IgA-Fc

2002 ◽  
Vol 277 (15) ◽  
pp. 12642-12648 ◽  
Author(s):  
Thomas Areschoug ◽  
Margaretha Stålhammar-Carlemalm ◽  
Ingrid Karlsson ◽  
Gunnar Lindahl
Keyword(s):  
Binding Sites ◽  
Human Factor ◽  
Factor H ◽  
Β Protein

scholarly journals Use of Animal Models To Support Revising Meningococcal Breakpoints of β-Lactams

2016 ◽  
Vol 60 (7) ◽  
pp. 4023-4027 ◽  
Author(s):  
Nouria Belkacem ◽  
Eva Hong ◽  
Ana Antunes ◽  
Aude Terrade ◽  
Ala-Eddine Deghmane ◽  
...  
Keyword(s):  
Human Factor ◽  
Susceptibility Testing ◽  
Bioluminescence Imaging ◽  
Factor H ◽  
Penicillin G ◽  
High Dose ◽  
Beta Lactams ◽  
Content Type ◽  
Resistance To Penicillin ◽  
Intraperitoneal Infection

ABSTRACTAntibiotic susceptibility testing (AST) inNeisseria meningitidisis an important part of the management of invasive meningococcal disease. It defines MICs of antibiotics that are used in treatment and/or prophylaxis and that mainly belong to the beta-lactams. The interpretation of the AST results requires breakpoints to classify the isolates into susceptible, intermediate, or resistant. The resistance to penicillin G is defined by a MIC of >0.25 mg/liter, and that of amoxicillin is defined by a MIC of >1 mg/liter. We provide data that may support revision of resistance breakpoints for beta-lactams in meningococci. We used experimental intraperitoneal infection in 8-week-old transgenic female mice expressing human transferrin and human factor H. Dynamic bioluminescence imaging was performed to follow the infection by bioluminescent meningococcus strains with different MICs. Three hours later, infected mice were treated intramuscularly using several doses of amoxicillin or penicillin G. Signal decreased during infection with a meningococcus strain showing a penicillin G MIC of 0.064 mg/liter at all doses. Signals decreased for the strain with a penicillin G MIC of 0.5 mg/liter only after treatment with the highest doses, corresponding to 250,000 units/kg of penicillin G or 200 mg/kg of amoxicillin, although this decrease was at a lower rate than that of the strain with a MIC of 0.064 mg/liter. The decrease in bioluminescent signals was associated with a decrease in the levels of the proinflammatory cytokine interleukin-6 (IL-6). Our data suggest that a high dose of amoxicillin or penicillin G can reduce growth during infection by isolates showing penicillin G MICs of >0.25 mg/liter and ≤1 mg/liter.

scholarly journals Human Factor H-Related Protein 5 Has Cofactor Activity, Inhibits C3 Convertase Activity, Binds Heparin and C-Reactive Protein, and Associates with Lipoprotein

2005 ◽  
Vol 174 (10) ◽  
pp. 6250-6256 ◽  
Author(s):  
Jennifer L. McRae ◽  
Thomas G. Duthy ◽  
Kim M. Griggs ◽  
Rebecca J. Ormsby ◽  
Peter J. Cowan ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Related Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cofactor Activity

scholarly journals Human Factor H Interacts Selectively withNeisseria gonorrhoeaeand Results in Species-Specific Complement Evasion

2008 ◽  
Vol 180 (5) ◽  
pp. 3426-3435 ◽  
Author(s):  
Jutamas Ngampasutadol ◽  
Sanjay Ram ◽  
Sunita Gulati ◽  
Sarika Agarwal ◽  
Chongqing Li ◽  
...  
Keyword(s):  
Human Factor ◽  
Factor H ◽  
Species Specific
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