scholarly journals Catch-Bond Mechanism of Force-Enhanced Adhesion: Counterintuitive, Elusive, but … Widespread?

2008 ◽  
Vol 4 (4) ◽  
pp. 314-323 ◽  
Author(s):  
Evgeni V. Sokurenko ◽  
Viola Vogel ◽  
Wendy E. Thomas
Keyword(s):  
Catch Bond ◽  
Bond Mechanism

scholarly journals Effect of loading conditions on the dissociation behaviour of catch bond clusters

2011 ◽  
Vol 9 (70) ◽  
pp. 928-937 ◽  
Author(s):  
L. Sun ◽  
Q. H. Cheng ◽  
H. J. Gao ◽  
Y. W. Zhang
Keyword(s):  
Multiple Bond ◽  
Tensile Load ◽  
Load Sharing ◽  
Loading Conditions ◽  
Bond Behaviour ◽  
Catch Bond ◽  
Linear Load ◽  
Bond System ◽  
Bond Mechanism ◽  
Catch Bonds

Under increasing tensile load, the lifetime of a single catch bond counterintuitively increases up to a maximum and then decreases exponentially like a slip bond. So far, the characteristics of single catch bond dissociation have been extensively studied. However, it remains unclear how a cluster of catch bonds behaves under tensile load. We perform computational analysis on the following models to examine the characteristics of clustered catch bonds: (i) clusters of catch bonds with equal load sharing, (ii) clusters of catch bonds with linear load sharing, and (iii) clusters of catch bonds in micropipette-manipulated cell detachment. We focus on the differences between the slip and catch bond clusters, identifying the critical factors for exhibiting the characteristics of catch bond mechanism for the multiple-bond system. Our computation reveals that for a multiple-bond cluster, the catch bond behaviour could only manifest itself under relatively uniform loading conditions and at certain stages of decohesion, explaining the difficulties in observing the catch bond mechanism under real biological conditions.

scholarly journals High force catch bond mechanism of bacterial adhesion in the human gut

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhaowei Liu ◽  
Haipei Liu ◽  
Andrés M. Vera ◽  
Rafael C. Bernardi ◽  
Philip Tinnefeld ◽  
...  
Keyword(s):  
Bacterial Adhesion ◽  
Human Gut ◽  
Catch Bond ◽  
Bond Mechanism

scholarly journals Plasma fibronectin stabilizes Borrelia burgdorferi–endothelial interactions under vascular shear stress by a catch-bond mechanism

2017 ◽  
Vol 114 (17) ◽  
pp. E3490-E3498 ◽  
Author(s):  
Alexandra F. Niddam ◽  
Rhodaba Ebady ◽  
Anil Bansal ◽  
Anne Koehler ◽  
Boris Hinz ◽  
...  
Keyword(s):  
Shear Stress ◽  
Borrelia Burgdorferi ◽  
Live Cell Imaging ◽  
Host Cells ◽  
Catch Bond ◽  
Bacterial Dissemination ◽  
Bacterial Interaction ◽  
Blood Constituent ◽  
Formed Part ◽  
Bond Mechanism

Bacterial dissemination via the cardiovascular system is the most common cause of infection mortality. A key step in dissemination is bacterial interaction with endothelia lining blood vessels, which is physically challenging because of the shear stress generated by blood flow. Association of host cells such as leukocytes and platelets with endothelia under vascular shear stress requires mechanically specialized interaction mechanisms, including force-strengthened catch bonds. However, the biomechanical mechanisms supporting vascular interactions of most bacterial pathogens are undefined. Fibronectin (Fn), a ubiquitous host molecule targeted by many pathogens, promotes vascular interactions of the Lyme disease spirochete Borrelia burgdorferi. Here, we investigated how B. burgdorferi exploits Fn to interact with endothelia under physiological shear stress, using recently developed live cell imaging and particle-tracking methods for studying bacterial–endothelial interaction biomechanics. We found that B. burgdorferi does not primarily target insoluble matrix Fn deposited on endothelial surfaces but, instead, recruits and induces polymerization of soluble plasma Fn (pFn), an abundant protein in blood plasma that is normally soluble and nonadhesive. Under physiological shear stress, caps of polymerized pFn at bacterial poles formed part of mechanically loaded adhesion complexes, and pFn strengthened and stabilized interactions by a catch-bond mechanism. These results show that B. burgdorferi can transform a ubiquitous but normally nonadhesive blood constituent to increase the efficiency, strength, and stability of bacterial interactions with vascular surfaces. Similar mechanisms may promote dissemination of other Fn-binding pathogens.

scholarly journals Catch-bond mechanism of the bacterial adhesin FimH

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Maximilian M. Sauer ◽  
Roman P. Jakob ◽  
Jonathan Eras ◽  
Sefer Baday ◽  
Deniz Eriş ◽  
...  
Keyword(s):  
Catch Bond ◽  
Bond Mechanism ◽  
Bacterial Adhesin

scholarly journals Catch bond mechanism suggested by GPIb alpha‐vWF tether bonds

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Leslie A Coburn ◽  
Jonathan J Miner ◽  
Tadayuki Yago ◽  
Suzanne G Eskin ◽  
Larry V McIntire
Keyword(s):  
Catch Bond ◽  
Bond Mechanism

scholarly journals Resolving the Molecular Determinants of Cadherin Catch Bond Formation

2014 ◽  
Vol 106 (2) ◽  
pp. 450a
Author(s):  
Kristine Manibog ◽  
Hui Li ◽  
Sabyasachi Rakshit ◽  
Sanjeevi Sivasankar
Keyword(s):  
Bond Formation ◽  
Catch Bond ◽  
Molecular Determinants

scholarly journals Integrin-like Allosteric Properties of the Catch Bond-forming FimH Adhesin ofEscherichia coli

2008 ◽  
Vol 283 (12) ◽  
pp. 7823-7833 ◽  
Author(s):  
Veronika Tchesnokova ◽  
Pavel Aprikian ◽  
Olga Yakovenko ◽  
Christopher LaRock ◽  
Brian Kidd ◽  
...  
Keyword(s):  
Ofescherichia Coli ◽  
Catch Bond ◽  
Bond Forming ◽  
Allosteric Properties

scholarly journals α-Catenin Forms an Unconventional Slip Bond with Actin that Switches Cooperatively into a Catch Bond

2021 ◽  
Vol 120 (3) ◽  
pp. 236a
Author(s):  
Marios Sergides ◽  
Claudia Arbore ◽  
Lucia Gardini ◽  
Francesco S. Pavone ◽  
Marco Capitanio
Keyword(s):  
Catch Bond
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